SOLICITATION NOTICE
66 -- One (1) brand name Yokogawa CV7000S high-throughput microscopy system, or equal
- Notice Date
- 6/6/2016
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02CO62599-78
- Archive Date
- 6/28/2016
- Point of Contact
- Francisco Mendoza, Phone: 2402765668
- E-Mail Address
-
francisco.mendoza@nih.gov
(francisco.mendoza@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- General Information Document Type:Combined Synopsis / Solicitation Notice Solicitation Number:N02CO62599-78 Posted Date:6/6/2016 Response Date:6/13/16 10:00 AM ET Classification Code:66 - Instruments and Laboratory Equipment NAICS Code:334516- Analytical Laboratory Equipment and Supplies Business Size Standard: 500 Employees Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E136, Rockville, MD 20850, UNITED STATES. Description The National Institutes of Health (NIH), National Cancer Institute (NCI), Center for Cancer Research (CCR), intends to procure one (1) brand name Yokogawa CV7000S high-throughput microscopy system, or equal. This is a combined synopsis/solicitation for commercial items, prepared in accordance with format in FAR 12.6 as supplemented with additional information included in this notice and under the authority to use simplified procedures for commercial requirements as provided in FAR 13.106. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation: No. N02CO62599-78 includes all applicable provisions and clauses in effect through FAR FAC 2005-88 (May 16, 2016). The North American Industry Classification System code is 334516 and the business size standard is 500 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. Description of Requirement The CCR plans to procure one (1) brand name Yokogawa CV7000S high-throughput microscopy system, or equal. The salient characteristics for the High-Throughput Microscope are: -The HTM must have a dual, microlens-enhanced spinning disk scanning unit for fast, high-sensitivity confocal imaging of cellular samples in the x, y and z dimensions. -The HTM must have a minimum of 2 sCMOS cameras. The camera chip size must have at a minimum 2560 X 2160 pixels, 5.5 Mp, 16.6x14mm view area, 6.5 micron pixel size) to enable simultaneous acquisition of a large field of view in two channels (Equivalent field of view with the 63X lens: 277 X 234 micrometers). -The HTM must have at a minimum an autofocus laser for fast, automated focusing of 2D cellular samples in flat-bottom imaging plates. -The HTM software must have image-based autofocus capabilities for imaging of samples in U-shaped bottom imaging plates and/or to image objects that are in different z-planes in different fields and/or different wells (e.g organoids or spheroids). -The HTM must have an environmental chamber with at a minimum temperature, CO2 and humidity control for long-term (at a minimum 72 hrs) live cell imaging. -The HTM must have an integrated tip-based single channel liquid dispenser unit with automated tip loading and ejection for fast automated kinetic imaging experiments. -The integrated liquid dispenser must be able to aspirate liquid from a reagent 96 well-plate and dispense into a 96-well or 384-well plate. -The integrated liquid dispenser must allow automated (with a robotic arm) loading and unloading of the reagent plated and tip boxes for kinetic experiments that require more than one source plate and/or more than one destination plate. -The aspiration/dispense/imaging operations of the integrated liquid dispenser must be fully programmable through the HTM software interface to allow automated kinetic imaging experiments. -The HTM must be capable to acquire non-binned images at a minimum of 5 or more frames per second (fps) during all the phases (Before, during, after) of reagent dispensing. -The HTM software must include automated image registration and optical aberration correction capabilities to allow automated high-content image analysis in multiple fluorescent channels. -The HTM software must include the option of performing flat-field-image correction capabilities to ensure homogeneity of the field of illumination over the imaging field covering cellular samples. -The HTM software must be capable to save non flat-field corrected images so that the investigator can save a copy of the image containing the original, unprocessed fluorescent intensity values. -The HTM software must be capable to run automated experiments on the same plate with at a minimum different objectives, and imaging channels, and camera binning, and camera exposures, and z-stack settings down to on a per single field of view basis. -The HTM software must be capable of running a minimum 3 multiple time-course experiments on the same plate with at a minimum 3 independent timelines. -The HTM software must be capable to select custom tiled fields of view to alow for maximum flexibility in the setup of the imaging experiment, particularly during the assay development phase. -The HTM software must be capable to integrate open source image-analysis software (at a minimum CellProfiler, ImageJ) in order to allow for custom written image analysis pipelines that fully and automatically control at a minimum the acquisition positions (fields and/or wells) and imaging settings (automated objective switching, imaging channels, camera binning, camera exposures, z-stack settings) in successive rounds of image acquisition (See below). -The HTM software must be capable at a minimum to first run an acquisition with a low magnification lens, send the images to open source image-analysis software (at a minimum CellProfiler, ImageJ), run custom written image analysis pipelines in open source image-analysis software (at a minimum CellProfiler, ImageJ), identify relevant cellular objects, automatically switch to a higher magnification lens, and acquire higher magnification images of the cellular objects of interest at the positions obtained by running the custom written image analysis pipelines in 3rd party image-analysis software. All these steps must be chained in an automated workflow without the need of operator intervention after the start of the workflow. -The HTM software must be capable to first run an acquisition only on positive and negative control wells, send the images to open source image-analysis software (at a minimum CellProfiler, ImageJ), run custom written image analysis pipelines in 3rd party image-analysis software, calculate statistically relevant assay quality controls parameters based on the image analysis results, and based on these results automatically decide whether or not to image all the remaining test samples on the same plate. All these steps must be chained in an automated workflow without the need of operator intervention after the start of the workflow. -The HTM must have at a minimum 6 lenses (At a minimum: 4X, NA 0.16; 10X NA 0.40; 20X, NA 0.75; 40X, NA 0.95; 60X water, NA 1.2) that must allow to be automatically switched to allow for both low-magnification and high-magnification acquisition of fluorescent images of cellular samples. -The HTM must have at a minimum 4 excitation lasers (405nm, 488nm, 561nm, 640nm). All the lasers must have at a minimum 100mW power to allow for short exposure times. -At a minimum The HTM must accommodate 6-, 24-, 48-, 96-, 384-, 1536-well imaging plates. -The HTM must be capable to image biological samples at least 90 microns thick. -The HTM must be capable to acquire images in epifluorescence modality to allow the image acquisition of a large sample volume in the z-dimension with low magnification objectives. -The HTM must be capable to acquire images in brightfield modality to allow the label-free imaging of cells during live-cell, time-lapse experiments in conjunction with the confocal mode. -The HTM must be capable to acquire images in digital phase contrast modalty to allow for the label free imaging of cells during live-cell, time-lapse experiments and subsequent object segmentation during the downstream image analysis phase. -The HTM must be capable to acquire images in true phase contrast modality. -The HTM must accommodate at a minimum 4 microscopy slides per slide adaptor. -The HTM must allow for automated (with a robotic arm) loading of slide adaptors to allow for increased throughputs for assays involving the image acqusition of tissues, or for cell-based assays that cannot be miniaturized in 96- or 384-well plate format. -In order to allow for unattended and automated plate-loading, the HTM must be integrated with an existing Denso 5-axis robotic arm, an existing barcode reader, an existing robot controller, 3 existing room-temperature plate hotels, and an existing robot PC provided by PerkinElmer. -The HTM and the all the components mentioned at the previous point must be integrated via scheduling software. Delivery: Contractor(s) shall deliver the item within 90 days after award to: NIH/NCI Bethesda, Maryland 20892. The Contractor that receives the award will be provided with the complete mailing address and point of contact. The contractor must notify the NCI Technical Point of Contact to schedule the delivery and installation date and time. Installation: To be carried out by the manufacturer and shall occur within approximately one week of delivery. Payment: Payment shall be made after delivery, installation and acceptance of the required equipment. PROVISIONS AND CLAUSES: The following Federal Acquisition Regulation and Health & Human Services Acquisition Regulation Provisions/Clauses apply to this acquisition: FAR 52.252-2 CLAUSES INCORPORATED BY REFERENCE (FEB 1998) This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at this/these address(es): http://www.acquisition.gov/far/ and/or http://www.hhs.gov/policies/hhsar/. FAR 52.212-1 INSTRUCTIONS TO OFFERORS-COMMERCIAL ITEMS (OCT 2015) FAR 52.212-3 OFFEROR REPRESENTATIONS AND CERTIFICATIONS- COMMERCIAL ITEMS (NOV 2015) FAR 52.212-4 CONTRACT TERMS AND CONDITIONS-COMMERCIAL ITEMS (MAY 2015) FAR 52.212-5 CONTRACT TERMS AND CONDITIONS REQUIRED TO IMPLEMENT STATUTES OR EXECUTIVE ORDERS-COMMERCIAL ITEMS (MAR 2016). The following FAR clauses cited in paragraph (b) of the clause at FAR 52.212-5 are also applicable to this acquisition: FAR Clause 52.203-6 Restrictions on Subcontractor Sales to the Government. FAR Clause 52.204-10 Reporting Executive Compensation and First-Tier Subcontract Awards. FAR Clause 52.209-6 Protecting the Government's Interest When Subcontracting with Contractors Debarred, Suspended, or Proposed for Debarment. FAR Clause 52.219-4 Notice of Price Evaluation Preference for HUBZone Small Business Concerns. FAR Clause 52.219-8 Utilization of Small Business Concerns. FAR Clause 52.219-28 Post Award Small Business Program Representation. FAR Clause 52.222-3 Convict Labor. FAR Clause 52.222-19 Child Labor-Cooperation with Authorities and Remedies FAR Clause 52.222-21 Prohibition of Segregated Facilities. FAR Clause 52.222-26 Equal Opportunity. FAR Clause 52.222-35 Equal Opportunity for Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans. FAR Clause 52.222-36 Affirmative Action for Workers with Disabilities FAR Clause 52.222-37 Employment Reports of Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans FAR Clause 52.222-40 Notification of Employee Rights Under the National Labor Relations Act. FAR Clause 52.223-18 Encouraging Contractor Policies to Ban Text Messaging While Driving. FAR Clause 52.225-3 Buy American-Free Trade Agreements-Israeli Trade Act. FAR Clause 52.225-5 Trade Agreements. FAR Clause 52.225-13 Restrictions on Certain Foreign Purchases FAR Clause 52.232-33 Payment by Electronic Funds Transfer-System for Award Management. FAR Clause 52.247-64 Preference for Privately Owned U.S.-Flag Commercial Vessels. HHSAR 352.203-70 ANTI-LOBBYING (DEC 2015) Pursuant to the HHS annual appropriations acts, except for normal and recognized executive-legislative relationships, the Contractor shall not use any HHS contract funds for: (a) Publicity or propaganda purposes; (b) The preparation, distribution, or use of any kit, pamphlet, booklet, publication, electronic communication, radio, television, or video presentation designed to support or defeat the enactment of legislation before the Congress or any State or local legislature or legislative body, except in presentation to the Congress or any state or local legislature itself; or designed to support or defeat any proposed or pending regulation, administrative action, or order issued by the executive branch of any state or local government, except in presentation to the executive branch of any state or local government itself; or (c) Payment of salary or expenses of the Contractor, or any agent acting for the Contractor, related to any activity designed to influence the enactment of legislation, appropriations, regulation, administrative action, or Executive order proposed or pending before the Congress or any state government, state legislature or local legislature or legislative body, other than for normal and recognized executive-legislative relationships or participation by an agency or officer of a state, local, or tribal government in policymaking and administrative processes within the executive branch of that government. (d) The prohibitions in subsections (a), (b), and (c) above shall include any activity to advocate or promote any proposed, pending, or future federal, state, or local tax increase, or any proposed, pending, or future requirement for, or restriction on, any legal consumer product, including its sale or marketing, including, but not limited to, the advocacy or promotion of gun control. HHSAR 352.222-70 CONTRACTOR COOPERATION IN EQUAL EMPLOYMENT OPPORTUNITY (DEC 2015) Full text copies of the representations and certifications for other cited provisions and clauses may be obtained on line at the NCI website at http://rcb.cancer.gov/rcb-internet/index.jsp or from Francisco Mendoza, Contracting Specialist at Francisco.mendoza@nih.gov. FAR 52.211-6 Brand Name or Equal (AUG 1999) (a) If an item in this solicitation is identified as "brand name or equal," the purchase description reflects the characteristics and level of quality that will satisfy the Government's needs. The salient physical, functional, or performance characteristics that "equal" products must meet are specified in the solicitation. (b) To be considered for award, offers of "equal" products, including "equal" products of the brand name manufacturer, must- (1) Meet the salient physical, functional, or performance characteristic specified in this solicitation; (2) Clearly identify the item by- (i) Brand name, if any; and (ii) Make or model number; (3) Include descriptive literature such as illustrations, drawings, or a clear reference to previously furnished descriptive data or information available to the Contracting Officer; and (4) Clearly describe any modifications the offeror plans to make in a product to make it conform to the solicitation requirements. Mark any descriptive material to clearly show the modifications. (c) The Contracting Officer will evaluate "equal" products on the basis of information furnished by the offeror or identified in the offer and reasonably available to the Contracting Officer. The Contracting Officer is not responsible for locating or obtaining any information not identified in the offer. (d) Unless the offeror clearly indicates in its offer that the product being offered is an "equal" product, the offeror shall provide the brand name product referenced in the solicitation. The award decision will be based on a Lowest Price Technically Acceptable (LPTA) determination. Award will be made on all or none basis. A technically acceptable quote is one that meets the salient characteristics, and meets the delivery and installations requirements. Quotations must be received in the NCI-OA contracting office by 7:00 a.m. ET on June 13, 2016. Please refer to solicitation number N02CO62599-78 on all correspondence. No collect calls will be accepted. Quotations shall be emailed to Francisco Mendoza, Contract Specialist at francisco.mendoza@nih.gov. All questions shall be in writing and may be addressed to the aforementioned individual noted above and shall be received by 10:00 a.m. ET on June 9, 2016. No collect calls will be accepted. In order to receive an award, contractors must be registered in the System for Award Management through sam.gov and have complete Representations and Certifications at sam.gov or provide a copy to the aforementioned individual prior to award.
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