SOURCES SOUGHT
65 -- Real Time PCR Instruments
- Notice Date
- 6/15/2016
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-2016-416
- Archive Date
- 7/15/2016
- Point of Contact
- Brian Lind, Phone: 301-827-5298
- E-Mail Address
-
lindbj@nida.nih.gov
(lindbj@nida.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only.   Background: The National Center for Advancing Translational Sciences (NCATS) focuses on getting more treatments to more patients more quickly. Several thousand genetic diseases affect humans, of which only about 500 have any treatment. A novel drug, device or other intervention can take about 14 years and $2 billion to develop, with a failure rate exceeding 95 percent. NCATS is directly addressing this problem by discovering new technologies and other approaches that could greatly accelerate the process of developing and deploying solutions that can be used by all translational researchers. The NCATS Chemical Genomics Center (NCGC) is tasked with identifying and developing novel small molecule leads against a wide spectrum of human disease targets, which it accomplishes by screening thousands of small molecules in collaboration with both intra-and extramural researchers. In pursuit of this goal, the Center has a strong internal transdisciplinary team of scientists who continually discover novel small molecules for application against a wide range of human diseases. A real-time polymerase chain reaction is a laboratory technique of molecular biology based on the polymerase chain reaction (PCR). It monitors the amplification of a targeted DNA molecule during the PCR, i.e. in real-time, and not at its end, as in conventional PCR. As such, this technique is needed as part of the many complex follow-up experiments the biologist carry out in discovering novel small molecules. At the moment we cannot use real-time PCR as an assay-readout in our automated HTS workflow because the only real-time PCR instruments available at NCATS only accommodates microtiter plates up to 384-well format. In addition to real-time PCR, NCATS has recently been implementing Cellular Thermal Shift Assays (CETSA) to assay direct binding of compounds to the cellular targets in cells. Purpose and Objectives: NCGC requests to purchase two (2) high-performance real-time PCR instruments to include into our high-throughput screening workflow and allow for additional assay-readout capabilities.   Project requirements: NCATS request to purchase two (2) high-performance real-time PCR instrument that meets the following capabilities Instrument Number One (1) • Must be compatible with 1536-well microtiter plate and allow for up to 1536 reactions per run • Must be able to work with 0.5 - 2 µL reaction volumes per well • The run time must be 50 minutes or less per plate • The instrument must have the ability to be programmed for automated running • Must allow for 2x multiplexing capabilities • Include one day of training for NCATS scientist • Provide one year warranty that covers all parts and labor and have a technical assistance hotline available Instrument Number Two: • Must be compatible with 96 and 384-well microtiter plates and 8-tube strips and allow for up to 384 reactions per run • Must be able to work with 10-100 and 5-20 µL reaction volumes per well • The run time must be 60 or 40 minutes or less per plate • The instrument must have the ability to be programmed for automated running • Must allow for 6x multiplexing capabilities • Include one day of training for NCATS scientist • Provide one year warranty that covers all parts and labor and have a technical assistance hotline available Anticipated period of performance: This is a one time delivery, to be made within eight (8) weeks of award
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-SBSS-2016-416/listing.html)
- Place of Performance
- Address: National Center for the Advancement of Translational Sciences, 9800 Medical Center Drive, Rockville, Maryland, 20852, United States
- Zip Code: 20852
- Zip Code: 20852
- Record
- SN04150606-W 20160617/160615234601-14fd80f2b7910748bfa4fbbc3602faed (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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