SOLICITATION NOTICE
Q -- Metabolomic Research
- Notice Date
- 8/1/2016
- Notice Type
- Presolicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02CP62636-36
- Archive Date
- 8/31/2016
- Point of Contact
- David H. Romley, Phone: 2402767822
- E-Mail Address
-
david.romley@nih.gov
(david.romley@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- General Information: Short Title: Metabolomic Research Document Type: Presolicitation Notice Solicitation Number: N02CP62636-36 Posted Date: 08/01/2016 Response Date: 08/16/2016 Classification Code: Q301- Medical - Laboratory Testing NAICS Code: 541712 - Research and Development in the Physical, Engineering, and Life, Sciences Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E144, Bethesda, MD 20892, UNITED STATES Description: National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Metabolic Epidemiology Branch (MEB), plans to procure on a sole source basis services for conducting a metabolomic profile association study using serum samples collected progressively in a nested case-control study of pancreatic cancer risk from Metabolon, Inc.; 617 Davis Dr. Suite 400; Durham, NC 27713. The response close date of this notice for this requirement is in accordance with FAR 5.203(a)(1). This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(2), and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 541712 and the business size standard is 1000 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The period of performance will be twelve (12) months from date of award. It has been determined there are no opportunities to acquire green products or services for this procurement. Metabolomics is a field of research devoted to the study of large numbers (>1000) of small molecules within biofluids,such as blood. Metabolomic profiles incorporate exposure from diet, lifestyle, the environment and genetics, among many other factors, that may be related to cancer risk. The Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), of the National Cancer Institute (NCI) is conducting a metabolomic profile association study using serum samples collected prospectively in a nested case-control study of pancreatic cancer. The aim of the study is to identify metabolites associated with pancreatic cancer risk. Purpose: The purpose of this procurement is to use metabolomics to identify biomarkers related to pancreatic cancer. The NCI will send 210 serum samples from pancreatic cancer case and control participants and quality control samples from the PLCO Study cohort. Samples are to be run using the Q-Exactive Mass-Spectrometry (MS) platform, with linkage of raw MS output to named and unnamed biochemicals. The contractor shall: 1. Store samples immediately in -80 degrees until ready for assays. 2. Measure metabolites using Q-Exactive MS on 210 PLCO samples. The samples will be sent boxed in batches of 32. All batches and samples within the batches should be assayed in the order provided by NCI. All samples will be sent at the same time. All analytical work performed by the contractor will be conducted under conditions of careful quality control and will follow their usual quality control procedures. All contractor internal quality control charts will be provided to NCI after the first batch and at completion of the work. NCI will review the data for the blinded quality control samples to assure that satisfactory reproducibility is being provided. 3. Link MS output to named and unnamed biochemicals from a reference database. 4. Communicate to Contracting Officer's Technical Representative (COTR) immediately via email or phone call if any problems. The contractor shall notify the COTR immediately via e-mail or phone call if any unusual problems develop over the course of the project and/or explanations for repeating analyses, such as failure of analytical and quality control procedures, breakdown of freezers, instrumentation and equipment, and major changes in personnel that would produce delays or that would adversely influence the quality of the laboratory performance. 5. Deliver data to the NCI Contracting Officer's Technical Representative (COTR) as tables of named and unnamed biochemicals and relative concentrations. This will be delivered by e-mail as either an Excel file or text file. 6. After the assays are run on each batch, residual samples will be stored in the laboratory at -80 degrees Centigrade. All biological materials provided by the U.S. Government, all residual specimens, and all data generated shall be the property of the U.S. Government and shall be returned to the U.S. government repository after the assays are completed and data approved by COTR. Government Responsibilities: The COTR will provide the contractor with anonymized serum specimens required for processing and analysis, review and approve all data, and provide consultation as needed. Reporting Requirements and Deliverables: The contractor shall provide to the NCI COTR the tables of named and unnamed biochemicals and relative concentrations, all linked to sample IDs by batch and position of sample in batch. Data shall be in Excel or text file. The contractor shall also return unused frozen serum samples sent frozen on dry ice via Fed-Ex, in original tubes where possible, to the NCI biospecimen repository, at the following address: NCI Frederick Central Repository c/o Fisher BioServices Attn: Alex Gonzalez 4600 Wedgewood Blvd. Suite H Frederick, MD 21703 Phone: 301-694-5911 Inspection and Acceptance Criteria: The COTR will verify compliance with the protocol, approve data from the analyses, and arrange for unused materials to be returned to the NCI biorespository. The Contractor's report (outlined above) shall be subject to review and approval by the COTR. Any deficiencies identified in these reports must be corrected within 2 weeks prior to final approval. These evaluations shall be performed in an ongoing fashion as needed. Payment: Payment will occur after data has been reviewed and considered acceptable. Payment authorization requires submission and approval of invoice to the NCI COTR and NIH OFM Commercial Accounts per the attached Invoice & Payment Provisions. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 12:00PM EDT, on August 16, 2016. All responses and questions must be in writing and faxed (240) 276-5401 or emailed to David Romley, Contract Specialist via electronic mail at David.Romley@nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid, current Entity Record, including current Representations and Certifications, in the System for Award Management (SAM) through SAM.gov. Reference N02CP62636-36: on all correspondence.
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