MODIFICATION
66 -- Multi-well Micro Electrode Array (MEA) Electrophysiology System
- Notice Date
- 8/24/2016
- Notice Type
- Modification/Amendment
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 3155, MSC 9593, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SS-494
- Archive Date
- 9/13/2016
- Point of Contact
- Danielle R. Brown, Phone: 301 594 1928
- E-Mail Address
-
danielle.brown2@nih.gov
(danielle.brown2@nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- The National Institute of Neurological Disorders and Stroke (NINDS) is a part of the National Institutes of Health (NIH), conducting research into the causes, treatment, and prevention of neurological disorders and stroke. The NINDS mission is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. The NINDS Neuro Therapeutics Development Unit (NTDU) and the Neural Differentiation Unit provide a resource for investigators at NINDS and other NIH Institutes to develop neuroprotective and neuroregenerative therapeutics entities. A significant part of this work includes development of cell based assays to identify, evaluate and characterize potential agents as possible treatments for neurological disorders. Our platform requires the generation of human induced pluripotent stem cell derived neuronal cultures for evaluation, characterization and quantitation of the protective actions of new and novel neurotherapeutic strategies. To assess the functionality of these human cultures derived from both normal control and patients with neurologic diseases, electrophysiologic measurements are appropriate parameters to validate the cultures. We plan to generate Induced Pluripotent Stem Cells (iPSC) and neural stem cells (NSC) from normal controls and patients with Chronic Fatigue Syndrome (CFS) and assess the morphologic and electrophysiologic properties of the stem cell derived neuronal cultures. This may help delineate the neurobiologic properties of CFS and their molecular function as a prerequisite to developing a therapeutic strategy for treatment of CFS.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA-SSSA-SS-494/listing.html)
- Place of Performance
- Address: 10 Center Drive, BLDG 10, Room 7C-213, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN04238994-W 20160826/160824235335-b3d48d137eb57c8fdabd417a288d0021 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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