SOLICITATION NOTICE
B -- DNA extraction, aliquoting, shipping and data preparation in Shanghai Women's Health Study (SWHS) and Shanghai Men’s Health Study (SMHS).
- Notice Date
- 9/8/2016
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02CP62703-61
- Archive Date
- 9/29/2016
- Point of Contact
- KATHY D. ELLIOTT, Phone: 240-276-5570, Seena Ninan, Phone: 240-276-5419
- E-Mail Address
-
ELLIOTTK@MAIL.NIH.GOV, ninans@mail.nih.gov
(ELLIOTTK@MAIL.NIH.GOV, ninans@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E224, Rockville, MD 20850, UNITED STATES Description The National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Occupational and Environmental Epidemiology Branch (OEEB) plans to procure on a sole source basis service to conduct DNA extraction, aliquoting, shipping and data preparation in SWHS and SMHS from Vanderbilt University, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN 37232-6307. This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and will be made pursuant to the authority in FAR 13.106-1 (b)(2) and 13.501-(a)(1) using simplified acquisition procedures for commercial acquisitions. The North American Industry Classification System code is 541990 and the business size standard is $15.0 Million. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The period of performance is twelve (12) months from date of award. It has been determined there are no opportunities to acquire green products or services for this procurement. The Division of Cancer Epidemiology and Genetics (DCEG) is an intramural research program of the National Institutes of Health (NIH), National Cancer Institute (NCI), that conducts population and multidisciplinary research to discover the genetic and environmental determinants of cancer and new approaches to cancer prevention. The purpose of this requirement is to conduct data preparation and extraction for night shift work and lung cancer studies, and buccal cell DNA extraction for lung cancer genomic studies. The Shanghai Women's Health Study (SWHS) is a large population-based prospective cohort study initiated in 1996. Approximately 75,000 Chinese women who lived in Shanghai were recruited into the study. In addition to survey data, blood and urine samples were collected from most study participants at the baseline recruitment. This cohort of women has been followed for cause-specific mortality and site-specific cancer incidence. The resources from this study have been used to support multiple projects that investigate genetic and other biomarkers as well as lifestyle factors for the risk and/or prognosis of cancers and other chronic diseases. The Shanghai Men's Health Study (SMHS) is a population-based cohort study that is being conducted in parallel with the Shanghai Women's Health Study. The cohort included 61,480 men at baseline. All cohort subjects are being followed up via biennial in‑person surveys and linking to the record linkage system with the Shanghai Tumor Registry and Shanghai Vital Statistics database. Exposure information is updated, and new chronic disease occurrences are ascertained during the in-person follow-up surveys. Cancer cases and deaths are verified by in‑home visits and review of medical charts or death certificates. Blood and urine samples were also collected at baseline. There is increasing evidence that shift work may have a greater risk of many chronic diseases including human cancer. In 2007, the International Agency for Research on Cancer (IARC) Monographs Working Group concluded that "shift-work that involves circadian disruption is probably carcinogenic to humans (Group 2A)". Many studies have reported that long term nightshift work may be reposeful for breast cancer and prostate cancer incidence. NCI have included nightshift work information in both SWHS and SMHS study questionnaires, so that the evaluations associate between nightshift work and cancer incidence and other chronic diseases. Cancer, including lung cancer, is a genetic disease. Approximately 10% of cancers are hereditary and occur due to alterations that confer a greater susceptibility to chemical, physical or viral agents. The genetic damage occurs in genes that affect the homeostasis of various biological processes such as proliferation, cell growth, apoptosis, angiogenesis, invasion and metastasis. Genomics and proteomics have been the best allies of the researchers in identifying biomarkers that can facilitate understanding of the mechanisms involved in the carcinogenesis in various tissues, such as the lung. The study of the genetic composition of the individual or population is also an important ally of contemporary medicine in attempts to understand the molecular mechanisms associated with oncogenesis and to develop a cure for cancer. Vanderbilt University, jointly working with the NCI, is conducting SWHS and SMHS, which provide valuable data and bio-sample resources to the shift-work study and genomic studies on lung cancer. This is an opportunity to study genomics of lung cancer risk in non-smokers using buccal cell samples from the study subjects who did not provide blood. Vanderbilt University is the only institute that has the database for the SWHS and SMHS, and that has the buccal cell samples for subjects from these cohorts. Vanderbilt University is identified as the only known contractor that can provide this service. The contractor shall perform the following tasks: 1. DNA extraction for 716 buccal cells samples from non-smoking cases of female and male lung cancer cases and 1:1 matched controls from SWHS and SMHS. 1.1. Extract and aliquot genomic DNA for 716 samples. 1.2. Ship DNA samples to NCI designated laboratory, and the remainder to NCI, based on the additional information provided by NCI. 1.3. Fill out the DNA sample file that will be provided by NCI, and ship them to NCI once it is finished. 2. Preparation and extraction for night shift work data in SMHS. 2.1. Extract night shift work data from SMHS study. 2.2. Conduct data analyses on the risk of nightshift work and all cancer incidence in SMHS. 3. Reporting Requirement and Deliverables The contractor shall email the NCI project officer biweekly to report the number of samples processed and data preparation and extraction status. The contractor shall deliver 1) DNA samples to the laboratory designated by the NCI, and the remainder to NCI, 2) night shift-work data analysis results from SMHS study in MS excel file to the NCI, no later than August 31, 2017. 4. Inspection and Acceptance Criteria NCI will have 15 days in which to review and accept this work as completed. If no comments or request for revisions are provided within 15 days, the deliverables shall be considered acceptable. 5. Human Subject Clearances Existing delinked data and DNA samples are exempt. This notice is not a request for competitive quotation. However, if any interested party, especially small business believes it can meet the above requirement, it may submit a proposal or quote for the Government to consider. The response and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 11:00 AM EST, on September 14, 2016. All responses and questions must be submitted via email to Kathy Elliott, Contracting Specialist at Elliottk@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must be registered and have valid certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA) through sam.gov. Reference: N02CP62703-61on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/N02CP62703-61/listing.html)
- Place of Performance
- Address: 9609 Medical Center Drive, Rockville, Maryland, 20850, United States
- Zip Code: 20850
- Zip Code: 20850
- Record
- SN04262199-W 20160910/160908234720-0d20753a87ce7f8f524cf98878a86b0b (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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