SOURCES SOUGHT
B -- Computational Biochemistry and Molecular Modeling Support
- Notice Date
- 11/4/2016
- Notice Type
- Sources Sought
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, Food and Drug Administration, Office of Acquisitions and Grants Services - Jefferson, 3900 NCTR Road, HFT-320, Bldg 50 | Rm 421, Jefferson, Arkansas, 72079, United States
- ZIP Code
- 72079
- Solicitation Number
- FDA1176299
- Archive Date
- 11/29/2016
- Point of Contact
- Nicholas E Sartain, Phone: 870-543-7370
- E-Mail Address
-
nick.sartain@fda.hhs.gov
(nick.sartain@fda.hhs.gov)
- Small Business Set-Aside
- N/A
- Description
- MARKET RESEARCH PURPOSES ONLY NOT A REQUEST FOR PROPOSAL OR SOLICITATION The U.S. Food and Drug Administration (FDA), is conducting market research to support the National Center for Toxicological Research (NCTR) requirement for Computational Biochemistry and Molecular Modeling Support. The FDA is seeking small business sources to determine the availability and capability of small businesses capable of providing the required services described herein. Other than small business concerns are also encouraged to submit capability statements. The following information is provided to assist the FDA in conducting Market Research to identify potential contractors for this effort: The associated North American Industry Classification System (NAICS) Code is-541711- Research and Development in Biotechnology; Small Business Size Standard is 1,000 employees. The FDA/NCTR, has a need for Computational Biochemistry and Molecular Modeling Support to support the FDA Medical Countermeasures Initiative (MCMi)-supported project E7391. The Contractor shall provide computational structural biochemistry and molecular modeling to predict relative thermal stabilities for the Staphylococcal enterotoxin A (SEA), Staphylococcal enterotoxin B (SEB), Staphylococcal enterotoxin G (SEG), Staphylococcal enterotoxin H (SEH), and Staphylococcal enterotoxin I (SEI) proteins using 3-dimensional structures for SEA, SEB, SEG, and SEH available to the public on-line via the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB) website (http://www.rcsb.org/pdb/home/home.do) or equivalent mirror sites. The services to be provided are essential for completion of goals associated with NCTR experiment E7391 entitled, "Thermal inactivation of Staphylococcal enterotoxins in milk." Performance requirements 1. Predict relative thermal stabilities at pH 6.7 for the SEA/SEB and SEB/SEG pairs using molecular modeling and methods that are equivalent to the one implemented in the FOLD-X software suite and molecular dynamics simulations in GROMACS (GROningen MAchine for Chemical Simulations software). Deliverable: full report on molecular dynamic simulations and estimate of relative thermal stabilities expressed in kcal/mol. 2. The Contractor shall model the structures of a series of selected n=10 single variants of SEA, SEB, and SEG and assess their relative stabilities. The Contractor shall use statistical modeling to predict relative thermal stabilities of all possible variants by combining these single point mutations, i.e. 210 = 1024 variants. Deliverable: estimates of relative thermal stabilities of variants expressed in kilocalories per mole. 3. The SEH isoform will be modeled based on structural homology with SEA. Molecular simulations will be used to estimate relative thermal stabilities of the SEA/SEH pair using standard methods described above. The impact of single point mutations on the modeled SEH isoform will be calculated. The Contractor shall then model a series of n=10 selected single amino acid substitutions for SEH, assess their relative stabilities, and apply statistical modeling to predict relative thermal stabilities of all 1024 variants for these mutants. Deliverable: full report on molecular dynamic simulations and estimate of relative thermal stabilities expressed in kilocalories per mole. 4. The SEI isoform has no close structural homologues available. Ab initio structural modeling will be performed using a library of structural fragments of 5 residues. The models will then be subjected to thorough molecular simulations to ensure the 3D structure models are correct. Relative thermal stabilities of SEA and SEI will be derived using GROMACS. Standard methods equivalent to the one implemented in FOLD-X algorithm will be used to estimate relative thermal stabilities. Deliverable: full report on molecular dynamic simulations and estimate of relative thermal stabilities expressed in kilocalories per mole. FOB Point Destination. All items/deliverables shall include shipping, handling and in-side delivery to the destination identified herein. FOB Point of Delivery for Services and Supplies will be the FDA located at 3900 NCTR Road, Jefferson, AR 72079. Period of Performance: All deliverables shall be completed and submitted to the Government within 180 calendar days after award. Full funding for this project and for this contract has been obtained through the FDA MCMi Challenge Grant Program. FDA MCMi approval for this project included approval for Peaccel as the provider for the computational biochemistry and molecular modeling services that are an integral and major component of the overall project. The FDA has determined that Peaccel has a successful record for providing computation biochemistry and molecular modeling support for the biotechnology and pharmaceutical industry. Peaccel investigators have established a strong record of scientific publications in the area of computation biochemistry and molecular modeling, demonstrating a history of successful collaborations with academic and nonprofit organizations. Other interested vendors may respond however for these reasons the federal government may decide to limit competition for this contract to Peaccel as a sole source procurement. The offeror shall furnish sufficient technical information necessary for the Government to conclusively determine that the offered products/services and components meet the technical requirements identified above. Though the target audience is small business manufacturers or small businesses capable of supplying a U.S. made product of a small business manufacturer or producer all interested parties may respond. At a minimum, responses shall include the following: • Business name, DUNS number, business address, business website, business size status (i.e., SB, VOSB, SDVOSB, HUBZone SB, SDB, WOSB, LB), point of contact name, mailing address (if different from business address), phone number and email address (Provide this same information if responding to provide a product manufactured by another firm); • Sufficient descriptive literature that unequivocally demonstrates that offered products and services can meet the above requirements. All descriptive material necessary for the government to determine whether the service/product offered meets the technical requirements including: technical specifications, descriptive material, literature, brochures and other information, which demonstrates the capabilities of the contractor to meet the requirement. • Provide recent (within the last 3 years) and relevant prior experience information for which the offeror has provided same or substantially similar Computational Biochemistry and Molecular Modeling Support services as set forth herein. Offeror should detail similar scope, complexity and magnitude. For each reference include period of performance, description (how is this relevant to current requirement), dollar value, your role and responsibilities as either a prime or subcontractor, client name, client address, client point of contact name, client point of contact phone number, and client point of contact email address. Respondents who do not provide a valid email address for the POC may be evaluated negatively. • Scientific publications in the area of computation biochemistry and molecular modeling, demonstrating a history of successful collaborations with academic and nonprofit organizations • If applicable, identification of the firm's GSA Schedule contract(s) by Schedule number and SINs that are applicable to this potential requirement. Detailed list of items included and not included on the GSA contract to meet this requirement. • Provide information if any of these specifications are too restrictive. No response will be considered that the listed specifications are adequate in a competitive environment. • If a large business, identify the subcontracting opportunities that would exist for small business concerns; • Standard commercial warranty and payment terms; and • Though this is not a request for quote, informational pricing is encouraged. The government is not responsible for locating or securing any information, not identified in the response. The Government encourages any comments and/or suggestions from any interested party, regarding the specifications. While the Government will not respond directly to your comments and/or suggestions; we will consider them as we finalize the specifications in preparation for the forthcoming solicitation. Interested Parties shall respond with capability statements which are due in person, by postal mail or email to the point of contact listed below on or before November 14, 2016 by 13:00 hours (Central Time in Jefferson, Arkansas) to nick.sartain@fda.hhs.gov, or mail to the Food and Drug Administration, OO/OFBA/OAGS/DAP, Attn: Nick Sartain, 3900 NCTR Road, Building 50, Room 422, Jefferson, AR 72079-9502. Reference FDA1176299. Notice of Intent Responses to this sources sought announcement will assist the Government in determining whether or not any future requirement similar to this one should be set aside for small business, made available to full and open competition or procure through sole-source acquisition procedures. Disclaimer and Important Notes This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in FedBizOpps. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/FDA/NCTR/FDA1176299/listing.html)
- Place of Performance
- Address: 3900 NCTR Road, Jefferson, Arkansas, 72079, United States
- Zip Code: 72079
- Zip Code: 72079
- Record
- SN04320984-W 20161106/161104234036-eae8333ca3164fa44f5ccd97015713bc (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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