SOLICITATION NOTICE
66 -- Microscope Upgrade for Muscle Energetics Laboratory
- Notice Date
- 11/16/2016
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-CSB-(HL)-2017-030-KMA
- Archive Date
- 12/13/2016
- Point of Contact
- Kevin Alvarez,
- E-Mail Address
-
kevin.alvarez@nih.gov
(kevin.alvarez@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION. The National Heart, Lung, and Blood Institute (NHLBI), Office of Acquisitions (OA), intends to negotiate and award a purchase order on a noncompetitive sole source basis to Leica Microsystems Inc., 1700 Leider Lane, Buffalo Grove, IL, 60089-6622, to upgrade NHLBI's current SP5 microscope system to an SP8 MP model. BACKGROUND The focus of NHLBI's Muscle Energetics Laboratory is to determine how mitochondria are optimized within muscle cells to help maintain energy homeostasis during the large change in energy demand caused by muscle contraction. Recently, the laboratory has demonstrated that skeletal muscle mitochondria form a highly connected network resembling that of an electrical power grid, and, indeed, were capable of electrical conduction of the mitochondrial membrane potential throughout the cell. The discovery of this rapid energy distribution mechanism overturned longstanding ideas regarding diffusion as the primary energy distribution pathway in skeletal muscle. Current work in this area is focused on providing a better understanding of the regulation and development of these mitochondrial networks as well as their role in overall muscle function. Despite much interest, control of mitochondrial function in vivo remains largely unclear as direct measures of mitochondrial enzymes in live animals have been limited. As a result, another major focus of the lab is to develop and utilize novel, direct measurements of in vivo mitochondrial function in skeletal muscle under different workloads. The goal of these studies is to unravel the signaling cascade involved in the upregulation of mitochondrial energy conversion during muscle contraction. PURPOSE The Muscle Energetics Laboratory is currently using a confocal microscope-a Leica SP5 confocal/multi-photon live animal imaging system-that is outdated and needs to be replaced. The laboratory has determined that the best course of action is to upgrade the current SP5 system to an SP8 MP model at a fraction of the cost to purchase a new SP8 MP system altogether. This upgrade will allow the lab to continue developing cutting edge live animal imaging techniques and significantly increase its capabilities for imaging live cells and tissue sections. The updated microscope system will play a vital part in investigating the relationships between skeletal muscle mitochondrial structure and function in the lab. PROCUREMENT The contractor shall upgrade the Muscle Energetics Laboratory's SP5 confocal microscope to an SP8 MP system. Specifically, the contractor shall replace the lab's DM6 CFS Stand (NHLBI Decal # 01839186), premium workstation (CPU) (NHLBI Decal # 01839162), and monitor (NHLBI Decal # 01839161) with the following SP8 components: •DM6 CFS Stand •Optical Outfit •Scan optics module VISIR with rotation •Tandem scanner 8 kHz •SP8 LIAchroics Compact RGB •One Internal Detector Channel (PMT) •Two Internal Detector Channels (HyD) •Confocal Lasers 405 nm, 488 nm, 552 nm and 638 nm •IR prepard (without IR Laser) •Custom Dual Beam Routing for MaiTai HP DeepSee (2) •Custom Quad Module for MicroMirror plus Hyd RLD 2ch (system has HyD 2Ch) •Premium Workstation, Monitor •Beam Splitter Quad LP 560nm •Beam Splitter Quad LP 505nm •Beam Splitter Quad Empty (for customization) In addition to providing these components, the contractor shall trade-in the old SP5 Confocal components for cost savings towards the new components. JUSTIFICATION Leica Microsystems, Inc. is the only company capable of performing this trade-in/upgrade. No other company possesses the technology, equipment and materials necessary to safely and accurately convert a Leica SP5 system to an SP8 system. This trade-in represents a significant cost-savings to the Government as Leica is offering $121,233.54 off of the purchase price of these new SP8 components with the trade-in of the old SP5 components. As a result, no other company is capable of meeting the work requirements of this contract. REGULATORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1(b), soliciting from a single source (for purchases not exceeding the simplified acquisition threshold) and only one responsible source and no other supplies or services will satisfy agency requirements. ADDITIONAL INFORMATION Industry Classification (NAICS) Code is 334516, Analytical Laboratory Instrument Manufacturing, and the Small Business Size Standard is 1,000 employees. The acquisition is being conducted under FAR Part 13, Simplified Acquisition Procedures, therefore the requirements of FAR Part 6, Competitive Requirements, are not applicable (FAR Part 6.001). The resultant award will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-89 (November 1st, 2016). This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by November 28, 2016 at 9:00AM EST and must reference synopsis number NHLBI-CSB-(HL)-2017-030-KMA. Responses shall be submitted to the National Heart, Lung, and Blood Institute, Office of Acquisitions, COAC Services Branch, 6701 Rockledge Drive, Room 6127, Bethesda, Maryland 20892-7902, Attention: Kevin Alvarez. Responses may be submitted electronically to kevin.alvarez@nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
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