SOLICITATION NOTICE
R -- PET and Quantitative data analysis of rCPS for auto-radiographic studies
- Notice Date
- 12/16/2016
- Notice Type
- Presolicitation
- NAICS
- #541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-NOI-2017-076
- Archive Date
- 1/18/2017
- Point of Contact
- Hunter A. Tjugum, Phone: 301 435 8780
- E-Mail Address
-
hunter.tjugum@nih.gov
(hunter.tjugum@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION PURSUANT TO FAR Subpart 5.2-Synopses of Proposed Contract Actions, THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT TO ACTION. THIS IS A PRE-SOLICITATION NON-COMPETITIVE NOTICE OF INTENT TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Station Support Contracts and Simplified Acquisitions Branch (SS/SA) on behalf of the National Institute of Mental Health (NIMH) intends to negotiate and award a contract to Kathleen Colette Schmidt, located at Silver Spring, MD 20901 for contractor support of PET and Quantitative data analysis of rCPS for auto-radiographic studies. The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, Kathleen Schmidt is the only vendor that has knowledge of the fully quantitative method for measuring rates of cerebral protein synthesis with L-[1-11C]leucine and positron emission tomography without providing an unacceptable delay or serious mission impairment to critical scientific support at NIMH. Therefore, Kathleen Schmidt is the only vendor that is capable of meeting this Government need. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) with a Size Standard of 1000 employees. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses of the Federal acquisition Requlation (FAR) in effect through the Federal Acquisition Circular (FAC) 2005-92 effective November 18, 2016. STATUTORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source. DESCRIPTION OF REQUIREMENT Project Description The Section on Neuroadaptation & Protein Metabolism (SNPM) at the NIMH studies the role of protein metabolism in adaptive responses of the nervous system. Long-term changes in the nervous system occur during development and aging, in response to synaptic activity and hormones, and as a result of disease or injury. These changes produce regional adjustments in protein metabolism that underlie growth, remodeling, degeneration, regeneration, and involution. SNPM has developed imaging methods for measuring rates of synthesis of proteins in all regions of the brain simultaneously. These methods can be applied to studies of both animals and human subjects. Measurements of protein synthesis can give a unique window into the normal adaptive responses of nervous tissue and may provide a means of monitoring both disease progression and treatment response. Purpose and Objectives The purpose of this requirement is for SNPM to obtain contractor support to provide data analysis services for the Section's positron emission tomography (PET) and quantitative auto-radiographic studies. Contractor shall provide data analyses for determining regional rates of Cerebral Protein Synthesis (rCPS) with the C-11 Leucine PET Method and the C 14 Leucine Quantitative Auto-radiographic Method on two (2) NIH IRB-approved protocol studies, 06-M-0214 and 09-M-0123. The SNPM developed a fully quantitative method for measuring rCPS with L-[1-11C]leucine and PET. The method was validated in rhesus monkeys by direct comparison of PET results with those from quantitative auto-radiographic and biochemical methods. Subsequently, SNPM performed PET studies to measure rCPS in healthy human subjects in the awake state and under propofol sedation and in subjects with Fragile X Syndrome. The section will conduct further PET studies in healthy subjects during sleep and memory consolidation, and in FrX subjects who can be studied awake or under an alternative sedating agent that does not alter rCPS in these subjects. The following scope of work shall be achieved from data analyses for each PET or auto-radiographic study required: 1.Evaluation of measured input functions, including smoothing and/or error-correction as necessary. 2.Estimation of arterial input functions from venous blood measurements. 3.Transformation of PET data to align with MRI data, and inverse transformation of MRI data to align with PET data as necessary. 4.Calculation of tissue time-activity curves (PET studies) or final tissue activity (auto-radiographic studies) for all regions of interest to the PI. Performance of data quality control, including examination of possible motion artifacts, coordination of additional reconstructions of the data if errors are found, performance of smoothing and/or error-correction as necessary. 5.Employment of the C-11 or C-14 Leucine Tracer Kinetic Model to estimate model parameters for the tracer in each region. Troubleshooting and correction of any problems that arise from ill-conditioned or outlier data. 6.Determination of rCPS for all regions of interest. 7.Updating Matlab software used for determining rates of cerebral protein synthesis with L [1-11C]leucine and positron emission tomography; performing additional analyses to include interconnected software of more than 500 Matlab scripts and functions that carry out all calculations; modifying the software to incorporate changes in data acquisition and/or analysis requirements; implementing input and instructions with thorough knowledge of the L-[1-11C]leucine method in order to set it up correctly; identifying and correcting any source of errors that arise during the analyses. Contractor will also be required to provide on an as needed basis the following tasks: 1.Advise Government officials on optimal methods of analysis independently performing the requisite analyses. 2.Respond to questions from any government laboratory personnel with the necessary mathematical and computational background who wish to perform analyses for future studies. 3.The contractor will furnish all necessary labor, material, supplies, and equipment other than a computer workstation that will be provided by the Government. 4.Data reports for each PET or auto-radiographic study analyzed. As each study is completed, the contractor will provide an interim summary report covering all subjects or animals in the protocol. A final summary report will be delivered upon completion of all studies in the protocol. All work will be monitored by the Government Contracting Officer's Representative (COR) or delegated official. Period of Performance The aniticpated period of performance for this potential requirement will be effective on or around January 16, 2017 through January 15, 2017 with the option to exercise two (2) additional subsequent one-year Periods of Performance. The Government estimates that approximately 1,000 hours of work shall be required to achieve this Statement of Work in base and all option years combined. CLOSING STATEMENT This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria. The price proposal must include the labor categories, an estimate of the number of hours required for each labor category, fully loaded fixed hourly rate or each labor category, breakdown and rationale for other direct costs or materials, and the total amount. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by January 3, 2017 at 9:00 AM, Eastern and must reference number HHS-NIH-NIDA-SSSA-NOI-2017-076. Responses must be submitted electronically to Contract Specialist, Hunter Tjugum, electronically at hunter.tjugum@nih.gov, and NIDASSSAPurchaseRequ@mail.nih.gov, and must reference the solicitation number HHS-NIH-NIDA-SSSA-NOI-2017-076 on your electronic request. FAX requests are not accepted. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
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