SOURCES SOUGHT
66 -- Hybrid Triple Quadrupole Linear Trap Mass Spectrometer Coupled With UPLC System
- Notice Date
- 1/24/2017
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Commerce, National Institute of Standards and Technology (NIST), Acquisition Management Division, 100 Bureau Drive, Building 301, Room B130, Gaithersburg, Maryland, 20899-1410, United States
- ZIP Code
- 20899-1410
- Solicitation Number
- NIST-MML-17-SS8
- Archive Date
- 2/21/2017
- Point of Contact
- DENNIS R. BAILEY, Phone: 3019756219
- E-Mail Address
-
dennis.bailey@nist.gov
(dennis.bailey@nist.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Institute of Standards & Technology (NIST) located in Gaithersburg, MD seeks information on vendors that are capable of providing a mass spectrometer system. The purpose of this notice is to identify organizations capable of providing this item. This announcement is not a Request for Proposals or Quotes (RFP/RFQ) and does not commit the Government to award a contract now or in the future. The information contained in this notice is DRAFT only and as such, is subject to change prior to issuance of a solicitation. No solicitation is available at this time. After results of this market research are obtained and analyzed, NIST may conduct a competitive or non-competitive procurement and subsequently award a contract. If at least two qualified small business sources are identified during this market research stage, this acquisition may be solicited as a small business set aside. NIST is seeking responses from all responsible sources, including large and small businesses (SB, SDB, WOSB, HUB Zone, SDVOSB and VOSB). This requirement is assigned a NAICS code of 334516, Analytical Laboratory Instrument Manufacturing, with a small business size standard of 1,000 employees. I. BACKGROUND INFORMATION The Organic Chemical Measurement Science Group within the Chemical Sciences Division of the Material Measurement Laboratory, National Institute of Standards and Technology (NIST) is responsible for chemical measurements leading to the certification of a large number of Standard Reference Materials (SRMs). Currently, the Organic Chemical Measurement Science Group is developing analytical methods and SRMs for clinically relevant molecules. The clinical analytes in SRMs are quantified using mass spectrometry. The best mass spectrometers for quantitation are triple quadrupole mass spectrometers, run in multiple reaction monitoring (MRM) mode. A triple quadrupole mass spectrometry coupled with a separation technique of a high-performance liquid chromatograph (HPLC) is the most widely used method for such measurements. We have begun research into analytical methods of clinical markers including estradiol, 1,25-dihydroxyvitamin D and Free forms of T4 and T3 present in complex matrices at low pg/mL levels. A mass spectrometer providing high instrumental sensitivity is necessary for quantitation of these markers at such low levels. The mass spectrometer must be capable of using and including a differential ion mobility spectrometry device (DMS) used for applications requiring the separation of isobaric species, isolation of challenging co-eluting contaminants and reduction of high background noise. The mass spectrometer must be capable of being interfaced with a commercially available differential mobility interface (DMS), which is also essential for separation from dirty matrices and identification of isobaric compounds and interferences. For increased confidence in identification of our compounds, while not sacrificing the analytical quantitative capabilities of a quadrupole based mass spectrometer, we require the mass spectrometer to perform as an ion trap for identification, as well as a quadrupole based mass spectrometer for quantitation. Furthermore, the instrument must possess the capability to perform MRM3 analyses, as the nature of our sample types include complex matrices with interferences, which may prohibit good MRM based analyses. II. SCOPE OF WORK Although there are a number of types of mass spectrometers available, not all of them provide high sensitivity, capability of being interfaced with a DMS, capability of performing MRM3 analysis, and capability of performing as an ion trap for identification as well as quantitation as a quadrupole based mass spectrometer to ensure accurate identification and quantitation of the species present in complex samples. Our existing liquid chromatography - tandem mass spectrometry (LC-MS/MS) instrumentation lacks such capabilities. In addition, the capability for reproducible and reliable upfront chromatographic separations with a pressure limit of 1200 bar or greater (ultrahigh pressure liquid chromatography, UPLC) are needed for improved sensitivity for use of columns with small particle sizes. The item to be acquired is an instrument system composed of an ultra-high pressure liquid chromatography (used for analyte separation) coupled to a hybrid triple quadrupole linear trap mass spectrometer (for analyte quantitation and identification). The system must have a triple quadrupole mass analyzer. Systems with time-of-flight or ion trap analyzers do not meet our requirements. Sources for the mass spectrometer shall include both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) and the system must be compatible with addition of a photoionization source at a later time. The mass spectrometer must also have the capability of being interfaced with a DMS and the capability to perform as an ion trap for identification, as well as a quadrupole-based mass spectrometer for quantitation. Furthermore, the instrument must possess the capability to perform MRM3 analyses. To provide the greatest functionality and ease of use, both the liquid chromatography and mass spectrometry instruments must work together using one instrument control software package with combined analysis methods. The data system, for instrument control and data analysis, must also be included with the liquid chromatography and mass spectrometry instruments. III. SPECIFICATIONS Mass Spectrometer (MS): • Must be a hybrid triple quadrupole linear trap mass spectrometer instrument. • Must be capable of using and including a differential ion mobility spectrometry device (DMS) used for applications requiring the separation of isobaric species, isolation of challenging co-eluting contaminants and reduction of high background noise. • The device must consist of an atmospheric pressure mobility cell located prior to the single thin aperture from atmosphere into the vacuum chamber. • The device must be able to acquire data for a single MRM transition in 25 msec including the inter-scan pause time of 20 msec. • The device must have an integrated liquid pump for the purpose of introducing chemical modifiers into the mobility cell. • The device must be user mountable and dis-mountable without the use of tools or breaking vacuum. The device must be mountable in less than 5 minutes and dismountable in less than 5 minutes when at room temperature. • Must have a mass range (m/z) of 5-2 000 Da in triple quadrupole mode. • The instrument must have a mass range (m/z) of 50-2 000 Da in linear ion trap mode. • The instrument must have a maximum scan speed of 12 000 Da/sec in triple quadrupole mode and 20 000 Da/sec in linear ion trap mode. • The instrument must be able to switch ionization mode polarity with a 20 msec settling time between polarities. The instrument is able to do this continuously. The total cycle time for acquiring 12 MRM transitions in positive mode, switching polarity acquiring 12 MRM transitions in negative mode and switching polarity again to positive mode is 160 msec. • Using the TurboIonSpray probe on the MRM3 transition of 609.3/397/365 for a 50 fg reserpine injection the instrument must have a S/N > 150:1 • The instrument must have a dynamic range of 6 orders of magnitude. • The instrument must have a mass stability of 0.1 amu over 8 hrs at m/z 906.7 with normal operating temperature and after it has reached vacuum and electronics equilibrium. • The instrument must have no significant crosstalk detectable for reserpine (0.17 pmol/uL infused) while monitoring the MRM transitions of 609/195 and 100/195 with a 1 ms dwell time and 3msec inter-MRM pause time. • The difference in response for Reserpine with 2 ms dwell and 3 msec inter-MRM pause time vs. 100 ms dwell with 10 msec inter-MRM pause must be < 10%. • The instrument must have full scan MS and selected ion monitoring for both Q1 and Q3, Product Ion Scan, Precursor Ion Scan, Neutral Loss or Gain Scan, Multiple Reaction Monitoring (MRM), Enhanced MS Scan, Enhanced Product Ion Scan, Enhanced Resolution Scan, MS3 scan, MRM3 Scan, and TripleTrap Scan Modes. • The instrument shall have the capability to perform electrospray ionization and atmospheric pressure chemical ionization in both the positive and negative ion modes. • The instrument shall have an integrated data system capable of controlling the instrument and associated liquid chromatographs, acquiring data and performing subsequent data analysis • The instrument shall be sold with appropriate power conditioning equipment (e.g. voltage booster) for its operation. A UPS shall be included. • Must include an Operations and maintenance manual covering proper operation, routine maintenance, and troubleshooting for the instrument and controlling software. o The manual may be supplied in hard copy or electronic format (or both). o A single manual covering both the MS and LC is acceptable should it cover both components. Liquid Chromatograph (LC) must consist of: • HPLC pump with a binary pump with a pressure limit of at least 1200 bar at up to 2mL/min. • Integrated inline membrane degasser. • AUTOSAMPLER with injection volume from 0.1 µL to 20 µL and sample temperature control from 4 - 40 °C. • COLUMN OVEN with a capacity of up to 8 columns and a temperature range of 10 °C below ambient to 100 °C. Will also include a column selection valve. • Must have a Photo Diode Array HPLC detector. • Software must have full and simultaneous control of the entire HPLC system, including pumps, autosampler, degasser, and column oven as well as full control over the QTRAP mass spectrometer using a single data system and software package. • Must have Jet weaver mixing technology. • Must include an Operations and maintenance manual covering proper operation, routine maintenance, and trouble-shooting for the instrument and controlling software. o The manual may be supplied in hard copy or electronic format (or both). o A single manual covering both the MS and LC is acceptable should it cover both components. Warranty: At least a one (1) year warranty on all parts, materials and labor for the analytical instrument. Installation: The Contractor shall install the instrument in Building 227, Room TBD, at NIST Gaithersburg, MD. Installation is to occur within 60 days of award. Training: The contractor shall provide three (3) days of training at NIST conducted by an application engineer for up to 6 NIST personnel.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/DOC/NIST/AcAsD/NIST-MML-17-SS8/listing.html)
- Place of Performance
- Address: 100 Bureau Drive, Gaithersburg, Maryland, 20878, United States
- Zip Code: 20878
- Zip Code: 20878
- Record
- SN04379115-W 20170126/170124234404-7552ed40d4f3189da828905b3d376bb6 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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