SPECIAL NOTICE
A -- Proposers' Day Notification for Proteos - IARPA-BAA-17-03 Proteos Program
- Notice Date
- 5/15/2017
- Notice Type
- Special Notice
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Office of the Director of National Intelligence, Intelligence Advanced Research Projects Activity, Washington, District of Columbia, 20511, United States
- ZIP Code
- 20511
- Solicitation Number
- IARPA-BAA-17-03
- Archive Date
- 7/18/2018
- Point of Contact
- Dr. Kristen Jordan,
- E-Mail Address
-
dni-iarpa-baa-17-03@iarpa.gov
(dni-iarpa-baa-17-03@iarpa.gov)
- Small Business Set-Aside
- N/A
- Description
- IARPA-BAA-17-03 Proteos Program Proposers' Day Conference DNA is the cornerstone of forensic science and is used for human identification in a variety of scenarios, e.g. criminal and missing persons investigations and the identification of human remains. Identification from biological material is dependent on the ability to characterize genetic polymorphisms in DNA. However, DNA is often recovered at very low quantities, is recovered as part of a complex mixture from several contributors, or it is degraded, all which complicate analysis and may obstruct meaningful results. Proteins are often associated with biological trace evidence such as hair and skin, and proteins are relatively more stable than DNA and can persist in the environment for longer periods of time. Protein also contains genetic variation in the form of single amino acid polymorphisms (SAPs). The Proteos Program seeks to analyze the relationship between polymorphisms in the proteome called genetically variable peptides (GVPs) and non-synonymous single nucleotide polymorphisms (SNPs) to provide an additional forensic tool for correlating an individual with particular objects, events, and locations. The Proteos Program is anticipated to be a three-phase program. Phase 1: Performers will be expected to develop a GVP discovery pipeline. Phase 1 of the Proteos Program will focus on discovery and identification of common GVPs recovered from protein in human touch samples. Performers will characterize proteomes expected in touch samples and identify GVPs that can be used for identification. Performers will also be expected to develop sampling protocols that do not preclude DNA analysis, therefore, demonstration of protein and DNA recovered from samples will be expected by the end of Phase 1. Performers in Phase 1 will be required to analyze GVPs from touch samples obtained from surfaces under varying conditions to include variability in time from deposition to sampling, variability in environmental conditions and surfaces to include brass shell casings, plastic bottles, and desktops. The end result should be a GVP discovery workflow that optimizes protein recovery and maximizes GVP discovery with a low false positive rate. Phase 2: Performers will build upon the GVP analysis pipeline developed in Phase 1 and identify rare or personal GVPs. Performers will be given exome sequence data of individuals and challenged to develop a rare GVP panel that will distinguish those corresponding individuals in mixtures of touch samples and demonstrate its performance. Throughout Phase 2, performers should continue to optimize sample extraction/purification for single and multiple rare GVP samples to minimize false positives. Phase 3: Performers will capitalize on technical advances accomplished in earlier phases and the performers will be expected to demonstrate a robust capability that is able to distinguish a rare GVP panel under operational scenarios. In this final phase, performers will be given exomic sequence information of individuals and then evaluated on the ability to distinguish each individual based on their rare GVP panel under varying collection conditions to include: degraded samples, varying heat and humidity, confounding factors such as multiple contributors, exogenous proteins in operational scenarios. Collaborative efforts and teaming arrangements among potential performers are highly encouraged. It is anticipated that teams will include multidisciplinary expertise in forensic science, proteomics, genomics, statistical analysis, molecular biology, and bioinformatics.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/notices/ddc2abb0b58db7f759999e32e84c9049)
- Record
- SN04508823-W 20170517/170515235011-ddc2abb0b58db7f759999e32e84c9049 (fbodaily.com)
- Source
-
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