SOURCES SOUGHT
66 -- Integrated fluidic circuit (IFC) based system for single cell functional analysis.
- Notice Date
- 6/29/2017
- Notice Type
- Sources Sought
- NAICS
- 333249
— Other Industrial Machinery Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SS-2017-487
- Archive Date
- 7/22/2017
- Point of Contact
- Rachelle Trice, Phone: 3018276732
- E-Mail Address
-
rachelle.trice@nih.gov
(rachelle.trice@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Federal Business Opportunities (FBO) SOURCES SOUGHT NOTICE 1. Solicitation Number: HHS-NIH-NIDA-SSSA-SS-2017-487 2. Title: Integrated fluidic circuit (IFC) based system for single cell functional analysis. 3. Classification Code: 66 - Instruments & laboratory equipment 4. NAICS Code: 333249 - Other Industrial Machinery Equipment 5. Description: This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: We are looking to purchase an automated cell preparation and dosing system supporting single cell functional analysis. To establish and move stem cell technologies forward through a more centralized effort, NIH has launched the Stem Cell Translation Laboratory (SCTL) within NCATS. Part of the NIH Common Fund, the goal of the SCTL is to bring iPSC technology closer to clinical application, drug discovery and regenerative medicine. Through the SCTL, NCATS will provide researchers across various disciplines and organizations with the ability to establish collaborations to advance the translation of regenerative medicine applications. Purpose and Objectives: The Polaris system enables users to select and individually capture 48 single cells on a chip, expose them to different stimuli in a controlled environment, and prepare their genetic material for gene expression analysis. It allows dose-response and time course experiments on single live cells, allowing them to study processes such as cell differentiation, immune response, neurogenesis, and cancer development. The Polaris system is an innovative integrated fluidic circuit (IFC) which enables Polaris to actively select single cells from heterogeneous cell samples and hold them in individual, environmentally controlled reaction chambers. Once isolated, cells can be challenged with a variety of factors, including transcription factors, RNAs and small molecules, at the dosage or intervals user defines. Then the cells are automatically lysed and RNA template is prepared for mRNA sequencing analysis. Project requirements: • Polaris System # 100-9000 • Polaris System Installation # PLS-SVCINT • Basic Install Application Training # APP-TRN • Polaris System Standard Service Plan # PLS-SVPSTD Salient characteristics: • Maximum size: 30" h x 21" w x 35" d • Maximum weight: 245 lbs • Integrated fluidic circuit (IFC) based system • Target cell selection by phenotype, viability or transgenic reporter • Touchscreen interface • Single integrated workflow to select, dose and prepare single cells • Carry out multi step molecular biology protocols on single cells • Onsite System Installation • Basic Install Application Training for 2 participants • One year standard service plan • Maximum experiment length: 24 hours • Minimum input 500 cells total • Selection sensitivity not to exceed >3% cell frequency • 4 hours maximum cell selection time • Simultaneous detection of 4 different excitation/emission wavelength combinations (438-700 nm) • Cell labeling selection based on any of the following: o Universal tracker o Viability stain o Labeled antibody to cell surface receptor o Fluorescent reporter gene Anticipated delivery requirements: One time delivery 3 weeks after receipt of order Other important considerations: N/A Capability statement /information sought. Respondents shall provide a capability response that clearly demonstrates the ability to meet the requirement specifications. Responses can include: • respondents' opinions about the difficulty and/or feasibility of the potential requirement or proposed acquisition, possible solutions and approaches that may currently exist in the marketplace, and information regarding innovative ideas or concepts; • information regarding respondents': (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information; • general information regarding the respondent's estimate or rough order of magnitude of the effort or time that may be required for completion of the work. (NOTE: This type of information may only be requested as part of an RFI. However, care must be exercised in requesting such information. Information requested must be: (a) necessary; (b) broad in scope; and (c) used for planning purposes only. Detailed estimates must not be requested.); The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted. The response must be submitted to Rachelle Trice at e-mail address Rachelle.Trice@nih.gov. The response must be received on or before 12:00 p.m. 7/07/2017 Eastern "Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA-SSSA-SS-2017-487/listing.html)
- Record
- SN04564427-W 20170701/170630000804-a2e2589d5f2a1de7c1228cd9ea8872f0 (fbodaily.com)
- Source
-
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