SOLICITATION NOTICE
A -- Solid Phase bead based system DNA sequencing for HLA typing in support of Naval Medical Research Center, Silver Spring, MD.
- Notice Date
- 7/26/2017
- Notice Type
- Presolicitation
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of the Navy, Bureau of Medicine and Surgery, Naval Medical Logistics Command, 693 Neiman Street, FT Detrick, Maryland, 21702-9203, United States
- ZIP Code
- 21702-9203
- Solicitation Number
- N32398HLATYPING
- Archive Date
- 8/25/2017
- Point of Contact
- Cheryl Vendemia, Phone: 3016196004
- E-Mail Address
-
cheryl.r.vendemia.civ@mail.mil.mil
(cheryl.r.vendemia.civ@mail.mil.mil)
- Small Business Set-Aside
- N/A
- Description
- Notice of Intent to Sole Source The Naval Medical Logistics Command (NMLC) intends to award a sole source contract to One Lambda, Inc., for continued development of an HLA typing system aimed at very large numbers of donors that allow transplant centers searching for matched donors to identify these individuals positively through complete allele level data on the search files used by the NMDP (National Marrow Donor Program) and Naval Medical Research Center (NMRC). This effort supports the expansion of the bone marrow screening program by improving the typing resolution and accuracy through continuous improvements in the solid phase (bead) based system paired with Deoxyribonucleic acid (DNA) sequencing for Human Leukocyte Antigen (HLA) in support of NMRC, Silver Spring MD. The estimated period of performance of this phase of the project is 12 months. If capable sources are not identified through this notice, NMLC intends to award a sole source contract under the authority of FAR 6.302-1 to One Lambda, Inc., 21001 Kittridge Street, Canoga Park, CA 91303-2801 for the performance of the described requirement. One Lambda, Inc. is the only source that has developed high resolution (HD) rSSO DNA typing reagents in the LABType® product family and accompanying IVD analysis software (HLA Fusion®). The collaboration with NMRC in the past year (and since 2007) has been very successful in continuing to develop specific probes to improve assay resolution and to meet the typing requirements of the DoD HLA typing program and bone marrow registry, the C. W. Bill Young Marrow Donor Program. The specific typing requirements include: -Development and manufacture of new HLA typing kits for combined bead based SSO and sequencing and provide the reagents to support NMRC donor recruitment for HLA A, B, C, and DRB, DQB and DPAB alleles to detect and discriminate between alleles found in the DoD BM donor pool, even if they are rare in the general population. -Develop and HLA test library preparation protocols and integration of existing NMRC automation equipment and modification of One Lambda software to be consistent with products being delivered -Test, evaluate and extend development of DNA primer pairs, DNA capture, and sequencing of the 3.6 MB region of the major histocompatibility complex genes. This will continue to increase the ability to identify unique gene sequences in the MHC genetic region to identify MHC haplotypes specific sequences that can be used for SSOP beads for identifying genetic characteristics of MHC that affect clinical outcome in unrelated donor transplants. Multiple genetic samples will be evaluated for consistency of identifying MHC haplotypes and to evaluate the haplotype (the linked set of alleles from within the major histocompatibility complex on chromosome 6 from HLA-A to HLA-DP) testing system in samples from complex genetic backgrounds based on known HLA alleles including transplant donors and matched recipients. C. W. Bill Young Marrow Donor Program will be provided the laboratory tools to be able to determine the specific haplotypes of each individual tested (haplotypes are the HLA - A, B, C, DR, DQ, DP as a linked set together with intervening MHC genes on each of the two haplotypes of individuals (one maternal and one paternal haplotype). This notice of intent is not a request for competitive proposals and no solicitation document exists for the requirement. Sources interested in responding to this notice are required to submit a capability statement that includes management and technical data and cost information, in sufficient detail and with convincing evidence that clearly demonstrates the capability to perform the required work. Capability statements shall not exceed 1 (8.5 x 11 inch) page using a font size no smaller than 10-point. All capability statements received by the due date of this notice will be considered by the Government. A request for documentation or additional information will not be considered as an affirmative response. A determination by the Government not to compete based on responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement or to proceed with a sole source contract. Capability statements are due by 3:00 PM Local Time, 10 August 2017. Capability statements shall be submitted by e-mail ONLY as a Microsoft Word or Adobe PDF attachment to the following address: cheryl.r.vendemia.civ@mail.mil AND thomas.l.hood26.civ@mail.mil.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/DON/BUMED/N62645/N32398HLATYPING/listing.html)
- Place of Performance
- Address: Naval Medical Research Center, Silver Spring, MD, Silver Spring, Maryland, 20910, United States
- Zip Code: 20910
- Zip Code: 20910
- Record
- SN04598835-W 20170728/170726231808-1a3b3cd556c8399b636e030ffc736072 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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