SOURCES SOUGHT
66 -- Alcohol Vapor System
- Notice Date
- 7/28/2017
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-2017-635
- Archive Date
- 8/22/2017
- Point of Contact
- Sneha V Singh, Phone: 3014802443
- E-Mail Address
-
sneha.singh@nih.gov
(sneha.singh@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- SOLICITATION NUMBER: HHS-NIH-NIDA-SSSA-SBSS-2017-635 Title: Alcohol Vapor System Classification Code: 6640 NAICS Code: 334516 Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. BACKGROUND The National Institute on Drug Abuse, Neurobiology of Addiction section is studying the neurobiology of alcohol dependence. Alcohol dependence is a complex psychiatric condition characterized by craving, compulsive drug seeking, excessive drug taking, and the emergence of negative emotional states during withdrawal. We have developed animal models that produce signs of drug dependence that strongly resemble the human condition. Rats are made dependent on alcohol by chronic, intermittent alcohol vapor exposure. Dependent rats escalate their alcohol intake over the course of vapor exposure. Air exposed rats exhibit stable intake levels and serve as nondependent controls (air or nondependent). Using these models, we investigate the neurobiology of alcohol dependence through the use of drugs that stimulate or block different neuronal messenger (neurotransmitter) molecules in the brain. PURPOSE AND OBJECTIVES The purpose of this acquisition is to acquire an alcohol vapor system to allow us to study the neurobiology of alcohol dependence and reach the goals of our laboratory. PROJECT REQUIREMENTS • Custom 4-chamber self-administration vapor inhalation system • The vapor inhalation chamber systems must produce robust models of drug dependence in mice in a precisely controlled environment to preserve animal's health. The inhalation systems must enable investigators to target and maintain specific blood drug levels. They must enable the investigator to have complete control of precisely how much drug is delivered and at precisely what scheduled timepoints drugs are delivered by enabling pre-set or customized exposure parameters. This allows the investigators to induce a wide range of biological changes to be systematically studied. The inhalation systems must allow drug delivery both passively and by self-administration. The inhalation systems must mimic human e-cigarette vaping of nicotine and THC, and can also deliver psychostimulants and opioids. The inhalation systems must allow the delivery of multiple drugs simultaneously. • The inhalation systems must mimic long-term laboratory rodent housing that laboratory rodents are accustomed to, with bedding, food and water. This results in little to no stress response during vapor exposure. • The inhalation systems must ‘scrub' the drug-laced air exiting the system by pulling that air through a charcoal-activated filter prior to allowing that air enters the institutional/house exhaust system. Most the drug under study is then trapped in the filter, allowing only negligible amounts to enter the house exhaust system. • The inhalation systems must allow precise control of drug delivery in a low stress and safe environment for both animal subjects and researchers, so that the users do not encounter the concerns/objections that are consistently raised by ACUC, EH&S and Facilities personnel. • Delivery to Baltimore, MD. Period of Performance: The anticipated delivery date for this acquisition is 60 days ARO. Capability statement: Contractors that believe they possess the ability to provide the required services should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. The capability statement should include 1) the total number of employees, 2) documentation of ability to provide the required support, 3) any contractor GSA Schedule contracts by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Contractors must also provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested organizations are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. All capability statements sent in response to this Sources Sought Notice must be submitted to Sneha Singh, Contract Specialist, via email at sneha.singh@nih.gov before the closing date and time of this announcement. All responses must be received by the specified due date and time in order to be considered. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
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