SOURCES SOUGHT
66 -- Individualized Low Amplitude Seizure Therapy EEG system
- Notice Date
- 8/1/2017
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 6001 Executive Boulevard, Room 3165, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-2017-643
- Archive Date
- 8/26/2017
- Point of Contact
- Hunter A. Tjugum, Phone: 3018275304
- E-Mail Address
-
hunter.tjugum@nih.gov
(hunter.tjugum@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION This is a Small Business Sources Sought (SBSS) notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability and type of qualified Small Business companies technically capable of meeting this potential government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. The notice is strictly for research and information purposes only. The information requested will assist the Government in determining the appropriate acquisition method including small business socio-economic set-aside possibilities and to determine the availability of qualified Small Business companies technically capable of meeting the Government's potential requirement. All Small Business companies with the capability and availability to perform the requirement under the applicable NAICS code are invited to submit a response to this notice. NORTH AMERICAN CLASSIFICATION SYSTEM (NAICS) CODE The NAICS code applicable to this requirement is 334516 Analytical Laboratory Instrument Manufacturing with size standard 1,000 employees. BACKGROUND The National Institute of Mental Health (NIMH) is one of 27 Institute Centers at the National Institutes of Health (NIH) committed to making important discoveries that improve health and save lives. NIMH is the lead federal agency for research on mental disorders. The mission of NIMH is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. The NIMH Intramural division plans and conducts basic, clinical, and translational research to advance understanding of the diagnosis, causes, treatment, and prevention of mental disorders through the study of brain function and behavior. The Experimental Therapeutics & Pathophysiology Branch (ETPB) is part of the National Institute of Mental Health (NIMH), a major research component of the National Institutes of Health (NIH). The ETPB conducts clinical research studies on mood disorders (including: major depressive disorder and bipolar disorder) with the goal of creating better ways to prevent, diagnose, and treat mental illness. Researchers at NIMH that specialize in Mood Disorders seek through research studies to develop medications that rapidly decrease symptoms of depression; identify biological characteristics (biomarkers); better predict with biomarkers who might respond to medications and treatments; and understand the mechanisms in the brain that are causing depression and response to treatments. At NIMH, research studies on mood disorders investigate how the depressed brain works, with a primary focus on the glutamate and cholinergic systems. Understanding how experimental medications may work to quickly lift severe and hard-to-treat depressive symptoms may lead to development of new, faster-acting treatments. Researchers at the ETPB also seek to understand what makes some people more likely to develop mood disorders. Purpose and Objectives This Small Business Sources Sought notice seeks to determine eligible sources capable of achieving the essential features of this potential requirement. The purpose of this potential requirement is to purchase an active channel amplifier with recorder software and electroencephalogram cap for transcranial magnetic stimulation (TMS). Project Requirements This potential requirement includes obtaining a system to study the effects of brain stimulation by measuring its electric activity. The lab uses electroencephalogram (EEG) technology to detect changes in this activity. EEG can detect differences on activity associated with some illness. One of our goal is record the brain activity while we stimulate the brain with electrical and magnetic therapies. By understanding the effects on the brain induced by various noninvasive brain stimulation modalities, we can better understand these treatment techniques for mental health and to develop more effective treatments. Despite advances in antidepressant interventions, none has replaced electroconvulsive therapy (ECT) in its acute efficacy and spectrum of action in severely depressed patients, including in psychotic depression, catatonia, and acutely suicidal patients. Consequently, approximately 100,000 patients in the United States and 1-2 million worldwide receive ECT each year. However, ECT carries a risk of significant adverse effects including cognitive and physiological side effects, some of which can be long term. The side effects are thought to be related to stimulation of brain areas beyond those implicated in depression, so called "non-target regions" which may contribute to neurocognitive side effects. Supporting this notion, modifications of seizure therapy technique which increase focality (e.g. right unilateral (RUL) electrode placement, ultrabrief pulse width (UB) ECT and magnetic seizure therapy (MST)) are associated with superior cognitive outcome compared with conventional bilateral, standard pulse width ECT. While these advances have improved the safety and tolerability of seizure therapy, a risk of cognitive side effects remains, and none of the currently used procedures individualize the current amplitude for each patient despite knowledge that anatomical variation significantly impacts the strength of the current delivered to the brain. The lab proposes the first in human safety and feasibility study of this approach (termed "individualized low amplitude seizure therapy", or iLAST). iLAST introduces several areas of improvement over conventional ECT. One such improvement is state-of-the-art computational electric field modeling on an individual patient basis to examine the current flow in the brain. Specifically, the following features are deemed essential that this potential requirement shall fulfill: 1. The EEG recording amplifier is compatitable with transcranial magnetic stimulation; 2. The EEG electrodes have active electronics to reduce recording noise; 3. Ultra high sampling rate of up to 100 kHz and wide hardware bandwith. The material or service must be compatible in all aspects (form, fit, and function) with existing systems presently installed. The current equipment is the MagVenture TMS stimulator, and the new item/service must be able to coordinate, connect, or interface with the existing system by software communication through software. Contractors submitting a response to this Small Business Sources Sought notice shall possess the ability to achieve the salient government essential features of this potential requirement. Specifically, Offerors to this Small Business Sources Sought notice shall document evidence of being able to provide the subject supply that will allow for the essential features described herein to be accomplished. Delivery/Warranty Offerors should indicate an estimated delivery time in full after receipt of an order and any other training or warranty or software licenses applicable. Inspection and acceptance will be performed at Building 10 on the NIH Main Campus located at 9000 Wisconsin Ave, Bethesda, MD 20814. CAPABILITY STATEMENTS SOUGHT Interested parties are expected to review this notice to familiarize itself with the requirements of this project. Failure to do so will be at your firm's own risk. Respondents must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in this announcement; (d) quantity; (e) shipping, handling, and/or installation instructions, and/or any special delivery conditions after receipt of an order. Respondents that believe that they are manufacturers or authorized re-sellers of the equipment specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; (d) quantity; (e) estimated price or cost; (f) shipping, handling, and/or installation charges; and delivery date after receipt of order. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. The information submitted must be in outline format that addresses each of the elements of this requirement. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) pages. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. Respondents must reference announcement number HHS-NIH-NIDA-SSSA-SBSS-2017-643 on all correspondence related to this Small Business Sources Sought notice. The response must be submitted to Hunter Tjugum electronically, at hunter.tjugum@nih.gov, and electronically to NIDASSSAPurchaseRequ@mail.nih.gov, and be received prior to the closing date specified in this announcement. CONCLUDING STATEMENTS Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
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- Record
- SN04606825-W 20170803/170801232059-b8ac5a8a920a06a80289f69093779e43 (fbodaily.com)
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