SOLICITATION NOTICE
66 -- microwave-assisted automated peptide synthesizer
- Notice Date
- 8/3/2017
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Child Health and Human Development, Contracts Management Branch, 6710B Rockledge Dr., Suite 1124, MSC7000, Bethesda, Maryland, 20892-7510, United States
- ZIP Code
- 20892-7510
- Solicitation Number
- NIH-NIDDK-17-214
- Archive Date
- 8/29/2017
- Point of Contact
- Amber Harris, Phone: 3014028778
- E-Mail Address
-
amber.harris@nih.gov
(amber.harris@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIH-NIDDK-17-214 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-95. The North American Industry Classification (NAICS) Code is 334516 and the business size standard is 1,000. However, this solicitation is not set aside for small business. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intend to procure on a sole source basis with BIOTAGE, INC. of 10430 Harris Oaks Blvd, Suite C. Charlotte, NC 28269 for the purchase of a microwave-assisted automated peptide synthesizer. The National Institute of Digestive, Diabetes & Kidney Diseases's (NIDDK) Solid State NMR and Biomolecular Physics Section of the Laboratory of Chemical Physics requires an automated, microwave-assisted peptide synthesizer for the production of polypeptides that are used in solid state nuclear magnetic resonance (NMR) studies of the molecular structures of amyloid fibrils associated with type 2 diabetes and Alzheimer's disease, studies of the molecular structural distributions of transient intermediates in protein folding and ligand binding processes, and a variety of related research projects. The synthesizer must be capable of producing polypeptide chains with lengths between 25 and 40 amino acids, with high yield and high purity, and on scales between 0.01 mmol and 0.2 mmol. Total synthesis times must be approximately 30 minutes per amino acid or less. It must be possible to synthesize polypeptides that include all 20 common amino acids and also include at least 8 nonstandard or isotopically labeled amino acids, without changing the synthesizer configuration during a synthesis run. It must be possible to use a variety of different Fmoc synthesis resins, including Wang resins, Rink amide resins, and PEG-based resins such as Tentagel and ChemMatrix resins. It must be possible to use a variety of amino acid activation and deprotection chemistries, including HOBt, HCTU, and Oxyma activation and piperidine and piperazine deprotection. It must be possible to control the microwave-heated temperature, duration, and reagent volume of each synthesis step by software. It must be possible to mix the contents of the synthesizer's reaction vessel during activation, coupling, and deprotection by oscillatory agitation. It must be possible to include acetic anhydride capping after some or all coupling steps, without changing the synthesizer configuration during a synthesis run. The synthesizer must include capabilities for monitoring the progress of deprotection reactions by UV absorbance and for automated adjustment of reaction times based on UV monitoring results. The specs are as follows: Initiator+ Alstra - Microwave Peptide Synthesizer US/JP - Alstra includes the following standard components: - Initiator+ Microwave System - Robot Sixty kit - Alstra pump module Start-up kit including: - 32 x 30 mL Amino acid rack, qty 1 - 32 x 30 mL Rack cover plate and foil septa - 30 mL Amino acid tubes, qty 100 - 185 mL Reagent bottles, glass, qty 5 - R1-4 Reagent bottle cover plate, qty 1 - R5 Reagent bottle cover plate, qty 1 - R1-4 Reagent bottle foil septa, qty 1 - R5 Reagent bottle foil septa, qty 1 - System solvent bottles: 1 x 5 L, 1 x 2 L, and 1 x L liter, GL45 brown glass bottles - 10 liter waste bottle, qty 1 - 5 mL Reactor vial with PTFE frit, qty 10 - 10 mL Reactor vial with PTFE frit, qty 10 - 30 mL Reactor vial with PTFE frit, qty 10 - Vial tool, qty 1 - 5 mL Reactor vial extension, qty 1 - 10 mL Reactor vial extension qty 1 - 30 mL Reactor vial extension, qty 1 - 5 mL/ 10 mL Reactor vial caps, qty 20 - 30 mL Reactor vial caps, qty 10 - Reactor vial plugs, qty 30 Alstra software Alstra UV Monitoring Kit Stylus Pen Kit for capacitive screens Installation and Familiarization Initiator Alstra Vacuum pump ME1C, complete with cables and connectors The proposed contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under authority of the 41 U.S.C. 253(c) (1), FAR 6.302. Only one responsible source and no other supplies or services will satisfy agency requirements. The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-1 Instructions to Offerors - Commercial Items; FAR Clause 52.212-2, Evaluation - Commercial Items; FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions applies to this acquisition. The offeror must include their Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.acquisition.gov/far/. Interested vendors capable of furnishing the government with the services specified in this synopsis should submit a copy of their quotation to the below address or via email to amber.harris@nih.gov. Offers must also be accompanied by descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all the foregoing requirements. Quotations will be due on or before August 14, 2017 by 10 am, EST. via email or postal mail. The quotation must reference "Solicitation number" NIH-NIDDK-17-214. Quotations sent by postal mail or other mailing services must be submitted to the following address: Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 1159A, Bethesda, MD 20817. Attention: Amber Harris, by the date and time mentioned above. Any questions must be sent via email to amber.harris@nih.gov and must include solicitation#NIH-NIDDK-17-214 in the subject line of email. Faxed copies/responses will not be accepted. PLEASE NOTE: In order to receive an award, contractor must be registered for "All Awards" and have a valid certification in the System for Award Management (SAM) database at http://www.sam.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NICHD/NIH-NIDDK-17-214/listing.html)
- Place of Performance
- Address: BETHESDA, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN04610295-W 20170805/170803231705-bb4cf8320c000622c0f8b6512c850d6e (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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