SOLICITATION NOTICE
66 -- Fully Automated Fluorescent Microscope with Laser Capture Microdissection and Line-Scanning Confocal Modules for the Inherited Movement Disorders Unit (IMDU)
- Notice Date
- 8/4/2017
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- HHS-NIH-NIDA-SSSA-CSS-17-541
- Archive Date
- 8/30/2017
- Point of Contact
- Jermaine Duncan, Phone: 3018277515
- E-Mail Address
-
jermaine.duncan@nih.gov
(jermaine.duncan@nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- Fully Automated Fluorescent Microscope with Laser Capture Microdissection and Line-Scanning Confocal Modules for the Inherited Movement Disorders Unit (IMDU) Competitive Combined Synopsis/Solicitation HHS-NIH-NIDA-SSSA-CSS-17-541 INTRODUCTION This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. This acquisition is being conducted in accordance with the procedures of FAR Part 13--Simplified Acquisition Procedures and FAR Part 12--Acquisition of Commercial Items. The solicitation number is HHS-NIH-NIDA-SSSA-CSS-17-541 and the solicitation is issued as a request for quotation (RFQ). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 334516 with a Size Standard of 1,000 employees. SET-ASIDE STATUS This acquisition is 100% set aside for small businesses. ACQUISITION AUTHORITY This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5- Simplified Procedures for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-95, dated January 19, 2017. The resultant contract will include all applicable provisions and clauses in effect through this date. DESCRIPTION OF REQUIREMENT Background The Inherited Movement Disorders Unit (IMDU) research focuses on genetic cause of movements disorders, with a particular focus on recessive causes of Parkinson's disease. To date, the IMDU researchers have investigated the roles of Pink1 and Parkin, two genes linked to recessive Parkinson's disease, in a mitochondrial quality control pathway in cell culture. Researchers want to incorporate genetically modified mice that model Parkinson's disease into studies to validate findings in cell culture. Additionally, the researchers want to validate novel methods for measuring mitochondrial protein turnover in vivo using transgenic mouse models. The fully automated fluorescent microscope with laser capture microdissection and line-scanning confocal modules is needed to capture small areas of interest from brain tissue and muscle for downstream DNA, RNA, and proteomics analysis. Additionally, the microscope is needed for imaging mitochondria in living acute brain slices. Purpose The purpose of this acquisition is to procure a fully automated fluorescent microscope with laser capture microdissection and line-scanning confocal modules for the Inherited Movement Disorders Unit (IMDU) laboratory. Project Requirements Purchase Description: Generic Name of Product: Fully Automated Fluorescent Microscope with Laser Capture Microdissection and Line-Scanning Confocal Modules Trade name: Nikon TI2-E PFS A1R Live Cell Confocal System Brand name: Nikon TI2-E PFS A1R Live Cell Confocal System Manufacturer's name: Nikon Model, type, catalog, and/or part number(s): PROMOA1R, MED53210, MXA22084, MRH11902, MRH20041, MRH20101, MRH48230, MRH48430, MQS41100, 10101, 10110, 10199, 10200, 10204, 10209, 2800-4, 2800-5, INST, 79035, M2700KT Salient characteristics Contractor must provide the IMDU with a fully automated fluorescent microscope with laser capture microdissection and line-scanning confocal modules that that meets the following specifications: •System must contain a high power Ultraviolet (UV) laser capable of cutting through thick sections (up to 200 microns) and a Piezo stage for fast imaging in the z-axis. •System must be fully automated and have a motorized x-y stage driver for precise control of cutting specimens with a UV laser. •System must be able to cut out tissue sections 3 microns or smaller from fixed tissue. •System must employ a tissue capture method that allows 100% direct visualization of tissue captured. •System must be able to capture tissue flat on a flat or slightly curved surface to aid visualization of captured material. •System must employ a tissue capture method that allows for two populations of captured cells to be segmented in separate clusters on a single tissue collection cap. •System must have a laser capture microdissection module that allows cutting of tissue with a UV laser and capture of the cut tissue (as specified above) that is simultaneously compatible with a confocal line-scanning module capable of capturing emitted light from a point at a resolution approaching the limit of light in the x, y, and z planes. •System must have a line-scanning confocal module that includes a hybrid scanner with paired galvanometers coupled to a high speed resonant galvanometer. •System's line-scanning confocal scanning module must capture a minimum of 30 frames per second at 512 X 512-pixel resolution and have high resolution ability to capture 4096X 4096 pixels at slower frame rates. •System's line-scanning confocal module must contain at least two (2) photomultiplier tubes and two gallium arsenide phosphide (GaAsP) detectors for sensitive multichannel photon detection. •System must have a 405 nm, 488 nm, 561 nm, 640 nm solid state lasers for excitation of specimen. •System must include one (1) set of phase lenses for UV laser cutting of the following magnifications/minimum NAs: 100x/1.3, 20x/.45, 40x/0.6. •System must include a 40X water immersion or silicon-oil objective with a working distance (WD) of at least 0.59 mm and an NA of at least 1.15. •System must include an airtable that is a maximum of 30 inch (wide) X 48 inch (height). The airtable must accommodate a microscope as well as the laser capture and confocal-line scanning modules. •System must include one (1) high definition monitor that is a minimum of 27 inches and one (1) PC computer with at least 128 GB ram suitable for microscope control both during laser capture microdissection and confocal imaging acquisition •System must include a calibrated digital transitor-transistor logic [TTL] input output card and integrated software for coordination of microscope operation with control of bath perfusion. •System must include microscope control software that is compatible with existing software systems (NIC elements, JOBS, General Analysis, control of a digital TTL input output card) to allow for the development of user-generated macros for complex control over image acquisition. •System overall dimensions must be a maximum of 30 (width) x 48 inches (height). •System must include an AC power cord and lens cleaning kit. Quantity: One (1) fully automated fluorescent microscope simultaneously compatible with laser capture microdissection and line-scanning confocal modules One (1) laser capture microdissection module compatible with a line-scanning confocal module One (1) line-scanning confocal module One (1) set of phase lenses for UV laser cutting of the following magnifications 100x/1.3, 20x/.45, 40x/0.6 One (1) 40X water immersion of silion-oil objective One (1) air table One (1) microscope control software One (1) Piezo stage One (1) transitor-transistor logic card One (1) PC computer and monitor for microscope control One (1) AC power cord One (1) lens cleaning kit Delivery or Deliverables Contractor shall deliver and installation the required equipment within 60 days after receipt of order. Delivery must be FOB destination and include inside installation, set-up and calibration. The equipment shall be delivered and installed between the hours of 8:00am and 5:00pm, Bethesda, MD local prevailing time, Monday through Friday. On-site training must take place at the customer site within 14 days of equipment installation. Training shall take place between the hours of 8:00am and 5:00pm, Bethesda, MD local prevailing time, Monday through Friday. The contractor shall provide an Original Equipment Manufacturer (OEM) certified service technician to perform setup, installation, calibration and training. Period of Performance Contractor shall provide one-year warranty on all equipment, parts and repairs and provide technical support services by an OEM certified service technician. All products shall be warranted to be free from material defects in workmanship or material under normal use and service for the warranty period. Contractor shall provide technical assistance to the Government by telephone, Skype and in person on an as needed basis during the warranty period. Place of Performance The place of performance shall be 9000 Rockville Pike Bethesda, MD 20892. Contract Type The Government intends to issue a firm fixed price order for this requirement. Invoicing shall be on a NET30 basis and payment shall be made via Electronic Funds Transfer (EFT). RESPONSE FORMAT Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria. Offerors must provide both 1) a technical response and 2) a separate price quote. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; and maintenance availability. The technical response should be prepared in reference to the evaluation criteria identified in this solicitation and may be up to ten (10) single-sided pages. Contractors must provide their Company Name, Dun & Bradstreet Number (DUNS), Taxpayer Identification Number (TIN), Business Size, Physical Address, and Point of Contact Information in their responses. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." EVALUATION CRITERIA The Government will award a contract resulting from this requirement on the basis of best value, technical factors and price considered. Technical factors together shall be considered more important than price and all technical evaluation factors are detailed below: Factor 1: Equipment Capability The contractor shall detail in its technical proposal how it shall meet each of the project requirements. This shall include detailed specifications of the offered equipment and its capabilities. Technical approach shall be evaluated for the ways in which the proposed equipment meets or exceeds the equipment specification requirements such as laser capture microdissection and line-scanning confocal modules; software compatibility and microscope hardware requirements. Exceeding requirements shall be considered favorably. Factor 2: Warranty The contractor shall detail in its technical proposal the terms and conditions for its proposed 1-year warranty, inclusive of parts and repairs and technical support services by an Original Equipment Manufacturer (OEM) certified technician. The proposed approach shall be evaluated for the ways in which it meets or exceeds the equipment warranty and maintenance specifications. Factor 3 Delivery, Installation and Training The contractor shall detail in its technical proposal how it shall meet the delivery, installation, calibration and training requirements. The Government shall evaluate for ability to meet or exceed these requirements. Proposals must include OEM service technical certifications, delivery lead-time and detailed explanation of set-up, installation, calibration. Contractor shall include training details as to what training will be provided and how it shall be delivered within the required timeframe. Factor 4: Past Performance The Contractor shall provide a list of two (2) contracts or purchase orders completed during the past five (5) years, similar in size and scope to the equipment requirements outlined in this solicitation. Experience must be specific equipment shall include the following information for each contract or purchase order listed: a.Name of Contracting Organization b.Total Contract Value c.Description of Requirement d. Contract Period of Performance Past Performance shall be evaluated for relevance to the current requirement. Technical proposals will be evaluated using a summary adjectival rating in accordance with the following scale: Excellent The proposal has exceptional merit and reflects an excellent approach which will clearly result in the superior attainment of all requirements and objectives. This clearly achievable approach includes several advantageous characteristics of substance, and very few disadvantages, which can be expected to result in outstanding performance. The risk of unsuccessful performance is very low as the proposal provides solutions which are unquestionably feasible and practical. These solutions are further considered very low risk in that they are exceptionally clear and precise, fully supported, and demonstrate a clear understanding of the requirements. Risk Level: Very Low Good The proposal demonstrates a sound approach which is expected to meet all requirements and objectives. This sound approach includes advantageous characteristics of substance, and few relatively minor disadvantages, which collectively can be expected to result in satisfactory performance. The risk of unsuccessful performance is low as the proposal contains solutions which are considered feasible and practical. These solutions are further considered to reflect low risk in that they are clear and precise, supported, and demonstrate an understanding of the requirements. Risk Level: Low Acceptable The proposal demonstrates an approach which is capable of meeting all requirements and objectives. The approach includes both advantageous and disadvantageous characteristics of substance, where the advantages are not outweighed by the disadvantages. Collectively, the advantages and disadvantages are likely to result in acceptable performance. The risk of unsuccessful performance is moderate, as the proposal solutions are generally feasible and practical. These solutions may also be considered to reflect moderate risk in that they may be somewhat clear and precise, partially supported, and/or demonstrate a general understanding of the requirements. Risk Level: Neutral Marginal The proposal demonstrates an approach which may not be capable of meeting all requirements and objectives. The approach has disadvantages of substance and advantages, which if they exist, are outweighed by the disadvantages. Collectively, the advantages and disadvantages present a low or questionable likelihood of resulting in satisfactory performance. The risk of unsuccessful performance is high as the proposal contains solutions which may not be feasible and practical. These solutions may also be considered to reflect high risk in that they lack clarity and precision, are generally unsupported, and/or do not demonstrate a complete understanding of the requirements. Risk Level: High Unacceptable The proposal demonstrates an approach which, based on a very high risk, will very likely not be capable of meeting all requirements and objectives. This approach has several disadvantages of substance, and advantages which, if they exist, are outweighed by disadvantages. Collectively, the advantages and disadvantages are unlikely to result in satisfactory performance. The risk of unsuccessful performance is very high as the proposal contains solutions which are not feasible and practical. The solutions may also be considered to reflect very high risk in that they lack any clarity or precision. Risk Level: Very High APPLICABLE CLAUSES AND PROVISIONS The following FAR clauses and provisions shall apply to this solicitation: 1.All Offerors MUST be actively registered in the System for Award Management (SAM) www.sam.gov. 2.The provision at FAR clause 52.212-1, Instructions to Offerors - Commercial Items (October 2015), applies to this acquisition. 3.FAR clause 52.212-2, Evaluation - Commercial Items (October 2014) applies to this acquisition. 4.A completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items (July 2016), is required with any offer submitted. This requirement may be met by completion of the provision in the System for Award Management. 5.FAR clauses 52.212-4, Contract Terms and Conditions - Commercial Items (January 2017) and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items (January 2017) apply to this acquisition. 6. FAR Clause 52.237-2 -- Protection of Government Buildings, Equipment, and Vegetation (April 1984) applies to this acquisition. 7.The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. In addition, the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." CONTRACTING OFFICER'S REPRESENTATIVE A Contracting Officer's Representative (COR) shall be assigned to the awarded contract. The COR is responsible for: (1) monitoring the Contractor's technical progress, including the surveillance and assessment of performance and recommending to the Contracting Officer changes in requirements; (2) interpreting the statement of work and any other technical performance requirements; (3) performing technical evaluation as required; (4) performing technical inspections and acceptances required by this contract; and (5) assisting in the resolution of technical problems encountered during performance. The Contracting Officer is the only person with authority to act as agent of the Government under this contract. Only the Contracting Officer has authority to: (1) direct or negotiate any changes in the statement of work; (2) modify or extend the period of performance; (3) change the delivery schedule; (4) authorize reimbursement to the Contractor for any costs incurred during the performance of this contract; (5) otherwise change any terms and conditions of this contract; or (6) sign written licensing agreements. Any signed agreement shall be incorporated by reference in Section K of the contract The Government may unilaterally change the COR designation for this contract. CLOSING INFORMATION Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. All responses must be received by the closing date of this announcement and must reference solicitation number HHS-NIH-NIDA-SSSA-CSS-17-541. Responses shall be submitted electronically via email to Jermaine Duncan, Contract Specialist, at jermaine.duncan@nih.gov
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