SOURCES SOUGHT
66 -- Plexon OmniPlex D Multi-Unit Recording System
- Notice Date
- 8/8/2017
- Notice Type
- Sources Sought
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-2017-689
- Archive Date
- 9/1/2017
- Point of Contact
- Zenab A. Chowdhry, Phone: 3018276909, Nancy Lamon-Kritikos,
- E-Mail Address
-
zenab.chowdhry@nih.gov,
(zenab.chowdhry@nih.gov, ontracting)
- Small Business Set-Aside
- N/A
- Description
- SOURCES SOUGHT NOTICE 1. Solicitation Number: HHS-NIH-NIDA-SSSA-SBSS-2017-689 2. Title: Plexon OmniPlex D Multi-Unit Recording System 3. NAICS Code: 541990 - All Other Professional, Scientific, and Technical Services Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, MD 20892. Introduction: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. North American Industry Classification System (NAICS) CODE: The NAICS code applicable to this requirement is 541990 - All Other Professional, Scientific, and Technical Services - and the associated business size standard of $15,000,000.00 Background Information: The National Institute of Mental Health (NIMH) is the lead federal agency for research on mental disorders. NIMH is one of the 27 Institutes and Centers that make up the National Institutes of Health (NIH), the nation's medical research agency. NIH is part of the U.S. Department of Health and Human Services (HHS). The mission of NIMH is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. For the Institute to continue fulfilling this vital public health mission, it must foster innovative thinking and ensure that a full array of novel scientific perspectives are used to further discovery in the evolving science of brain, behavior, and experience. In this way, breakthroughs in science can become breakthroughs for all people with mental illnesses. To assist in ongoing research, the Unit on the Neurobiology of Affective Memory (UNAM) seeks to purchase an OmniPlex D multi-unit recording system from Plexon, to perform in vivo characterization of single neuron activity in the midline thalamus of freely behaving mice. Research in our unit recently identified the cellular mechanisms underlying the role of the midline thalamus in stress modulation. Using imaging methods, we discovered that the activity of midline thalamic neuron increases during stress. However, thalamic neurons in general display two modes of action potential firing that depend on distinct cellular mechanisms. It is thought that these firing modes relay different types of information to cortical - and in the case of the midline thalamus, limbic structures. We seek to address this issue by directly assessing the spiking activity of midline thalamic neurons during stress and stress related behaviors. In addition, the spike resolution obtained from in vivo electrophysiological experiments with the OmniPlex D, will allow us to focus on other aspects of information processing in the midline thalamus in the context of stress that are currently not possible to obtain with the imaging methods available in our lab. Purpose and Objectives for the Acquisition: Multi-unit recordings of neuronal responses in the brain of freely behaving animals is a very powerful approach for correlating single-cell neuronal activity with behavior. Thanks to recent improvements in multi-unit recording methods, this technique can allow for genetic and/or pathway specific identification of neurons using optogenetics. Together, this optogenetically-synchronized electrophysiological approach provides an unparalleled method for identifying the circuit bases of behavior. Our Unit on the Neurobiology of Affective Memory seeks to uncover the cellular and circuit mechanisms by which the paraventricular nucleus of the thalamus (PVT), a midline thalamic structure, coordinates behavioral and neuroendocrine responses to stress. Recently, we have made tremendous progress towards understanding the cellular mechanisms in PVT that participate in the regulation of stress-related responses. However, a critical step in furthering our findings is to identify the relationship between single neuronal activity in PVT and the behavioral responses to stress. Thus, our objective is to implement the OmniPlex D system by Plexon to fill this gap in our work. Contractor Requirements (Scope of Work): The contractor shall be able to provide a Multi-Unit Recording System to perform in vivo characterization of single neuron activity of freely behaving mice combined hardware and proprietary software package. Specifically, the following: 1. Purchase Description • OmniPlex D-DHP - OmniPlex Neural Data Acquisition System chassis for use with Plexon Digital Headstages. Includes 32 digital external event inputs, 32 ch digital outputs, and 32 ch auxiliary analog inputs (5KHz AD/ch), 40KHz simultaneous sampling Product # 94218 quantity 1 • Digital Headstage Processor DHP/32 32 channel Digital Headstage Processor required for use with digital headstages and OmniPlex D-DHP chassis Product # 94220-032 quantity 1 • OmniPlex D SW/32 - DHP OmniPlex software required for use with 32 channel, OmniPlex D neural data acquisition system with digital headstages. Requires Plexon-configured computer Product # 94219-032 quantity 1 • HST/16D GEN2 16-channel digital headstage (Gen2) Product # 31012-100 quantity 1, • HST/32D- 32-channel digital headstage, Product # 91710 quantity 1 • HSC/DHSC3-36L Digital Headstage cable, channel count independent, black cable, 36-inch length Product # 91781-036 quantity 2, • HTU/16V-LN Headstage tester unit for 16 channel Low Noise VLSI headstage Product # 91055 quantity 2 • CBL/DI-OmniPlex-BW-6L Digital input cable for OmniPlex system; bare wire (no connector) at distal end; 6ft length Product # 92347 quantity 1 • PLX-4 System Controller Dell 4-core Workstation, W7-64, 3.5 GHz, 16 GB ram, 256 GB SSD & 1 TB hard drive, dual video, DVD/CD, MS Office product # 80001-002 quantity 1 • MON-24 Dell 24" Ultrasharp 1920X1200 Monitor Product # 91167-001 quantity 1 • INS On-site installation and training (domestic) Product # 51211 quantity 1 • OFS/v4 w/OmniPlex D purchase Offline Sorter software, version 4 bundled with purchase of Omniplex D neural data acquisition system. Includes OFS manual, 2 usb keys Product # 99952-403 quantity 1 • NEX/v5-1usb NeuroExplorer data analysis software, version 5. Includes a manual and a single seat license (1 USB license key) Product # 92229-001 quantity 1 • CPX/V3-I-OPX CinePlex digital video recording & neural data file sync system; version 3; includes CPX Studio & Editor software; CPX license. Requires Plexon-configured computer Product # 91113 quantity 1 • CPT-V3 CinePlex V3 tracking option - online and offline tracking/editing, calibration complex arenas Product # 99973 quantity 1 • CPB-V3 CinePlex Behavior - static and dynamic zones, events, digital output (requires CPT-V3); includes USB DO Product # 99974 quantity 1 • CBL/DI-OmniPlex-BW-6L Digital input cable for OmniPlex system; bare wire (no connector) at distal end; 6ft length Product # 92347 quantity 1 • CPX/CAM-AVT-Stingray AVT Stingray camera, CS-mount w/FireWire-B and trigger cables, tripod adapter, and mounting kit; 80 FPS capture in single and dual camera mode; removable filter for recording in infrared mode Product # 21956 quantity 1 • CPX/CAM-LENS-STANDARD CPX-Lens 3X 4.5-12.5mm F1.2 ½" CS mount - standard lens Product # 52154-004 quantity 1 • OPT/Carousel M Commutator 2LED-4DHST-TH Carousel Motorized Commutator for use with up to 4 digital headstages for neural recording and/or up to 2 magnetic PlexBright Compact LED Modules for optogenetics stimulation; with through-hole down the center Product # 91397-205 quantity 1 • OPT/LED_Blue_Compact_LC_magnetic PlexBright optogenetic stimulation system magnetically mounted compact LED module for use with commutator, terminating in an LC connector for use with an LC patch cable. Blue, 465nm, 300mA max current. Product # 40652-101 quantity 1 • OPT/LED_Orange_Compact_LC_magnetic PlexBright optogenetic stimulation system magnetically mounted compact LED module for use with commutator, terminating in an LC connector for use with an LC patch cable. Orange, 620nm, 250 mA max current. Product # 40652-105 quantity 1 • OPT/PC-LC-FCF-200/230-HD-1.0L KIT PlexBright optogenetic stimulation system patch cable kit. 200/230μm high durability fiber; LC connector to compact LED module; FC ferrule with polishedfiber on distal end; 1.0 m in length. Kit includes patch cable, package of 5 FC ceramic sleeves, and LC-LC coupler. Product # 94024-100 quantity 2 • OPT/1ch_LED_Driver PlexBright optogenetic stimulation system single channel LED Driver; includes amplitude modulation control w/ digital read-out, digital and analog input; for control of PlexBright LED modules. Includes 1 standard BNC cable. Product # 51382 quantity 1 • DSC/special Special one-time discount Product # 51208 quantity 1 • SHP Shipping and handling charges UPS FOB Product # 51212 quantity 1 2. Salient characteristics The UNAM requires Multi-Unit Recording System to perform in vivo characterization of single neuron activity of freely behaving mice combined hardware and proprietary software package:  Must have Real-time spike sorting in single electrode, stereotrode, or tetrode mode. Online sorting in both waveform space (time/voltage) and directly in feature space (PCA, Maxima/Minima, and others). Box, line, band, and template spike sorting in time/voltage space. 2D contour, 2D ellipse, and 3D ellipse spike sorting in feature space.  Must have automatic sorting using valley-seeking and t-distribution expectation/maximization algorithms.  Must have Automatic gain and thresholding.  Must have Real-time spike timestamp, waveform, and digital event data link to user-defined Matlab and C++ Clients, for customer-specific on-line analyses. This is critical for the end users based on their previous coding skills  Must have Real-time perievent histogram plots.  Needs to be equipped with Real-time TCP-IP data transfer of spike timestamps, spike waveform, sorted unit assignment, to remote computers, allowing real-time data analysis on remote computers.  Must have Real-time data link with NeuroExplorer data analysis program, cross-correlation analyses, for real-time JPSTH plots, perievent raster and histogram analyses, burst analyses, etc. NeuroExplorer is software package for neurophysiological data analysis for presentations.  Must have real-time interspike interval histogram display, with warning indicator for spike with interspike intervals less than user-defined refractory period.  Head stages must meet following criteria High-density, lightweight headstage amplifiers for mounting on animal's head. 16-channel headstage: 21x11x3 mm (length x width x height), 2.25 grams; 32-channel headstage: 23x17x3 mm (length x width x height), 2.75 grams.  Must have up to 32 digital inputs for external synch and experiment state variables from behavioral equipment, as individual TTL lines or multi-bit strobed words.  Must be scalable from 16 to 256 channels, in 16-channel increments with simultaneous 40kHz A/D conversion on each channel at 16-bit resolution with 40kHz sampling rate on each channel, for high temporal resolution of spike waveforms -critical for discriminating different neuronal types based on spike waveform shape  Must be equipped with software programmable digital filtering for wide-band, field potential, and spike frequency band isolation  Must provide lifetime Technical Support for all software and hardware  Must be compatible with Lafayette operant and touch screens which are heavily used in NIMH's Rodent Behavioral Core and will be used by Requester  Acquired system must have tracking system that may be operated in full synchronicity with neural data acquisition. This involves a trigger time frame capture from the same shared timing clock.  Acquired system must come with a motorized carousel commutator for use with up to four headstages and compatible for dual use with optogenetics. 3. Quantity: 1 Multi-Unit Recording System to perform in vivo characterization of single neuron activity of freely behaving mice combined hardware and proprietary software package from Plexon Anticipated period of performance: Delivery by September 15, 2017 or 30 days post ARO This is an anticipated firm fixed price purchase order. Capability Statement: Contractors that believe they possess the ability to provide the required services should submit documentation of their ability to meet the project requirements to the Contract Specialist. Contractors should also provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested organizations are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. All capability statements sent in response to this Small Business Sources Sought Notice must be submitted electronically (via email) to Zenab Chowdhry, Contract Specialist, at zenab.chowdhry@nih.gov in MS Word format within 10 calendar days of the date of this announcement. All responses must be received by the specified due date and time in order to be considered. Note: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in the response. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After review of the responses received, pre-solicitation and solicitation notices may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. The solicitation release date is pending. The Government intends to negotiate a fixed-price contract. Contracting Office Address: 9000 Rockville Pike Building 31, Room 1B59 Bethesda, Maryland 20892 United States
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