SOURCES SOUGHT
66 -- TCS SP8 STED 3X Microscope Upgrades for the National Institute of Neurological Disorders and Stroke (NINDS) Synaptic Transmission Section - Sources Sought Document
- Notice Date
- 8/9/2017
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SS-17-695
- Archive Date
- 9/6/2017
- Point of Contact
- Jermaine Duncan, Phone: 3018277515
- E-Mail Address
-
jermaine.duncan@nih.gov
(jermaine.duncan@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Attached is the sources sought document. Federal Business Opportunities (FBO) SOURCES SOUGHT NOTICE 1.Solicitation Number: HHS-NIH-NIDA-SSSA-SS-17-695 2.Title: TCS SP8 STED 3X Microscope Upgrades for the National Institute of Neurological Disorders and Stroke (NINDS) Synaptic Transmission Section 3.Classification Code: 66 - Instruments & laboratory equipment 4.NAICS Code: 334516 - Analytical Laboratory Instrument Manufacturing Description This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background The National Institute of Neurological Disorders and Stroke (NINDS) Synaptic Transmission Section (STS) combines news technique of microscopy and cell biological approaches to investigate the fundamental process of exocytosis and endocytosis as well as how the fusion pore opens, expands and close. Fluorescence microscopy is a fundamental technique used in the laboratory and the FLIM module upgrade is required to study the molecular mechanism of the fusion pore opening and closure. The 775 STED laser is required to improve the visualization of proteins involved in the exocytosis and endocytosis process without serious photobleaching or phototoxicity during super-resolution imaging. Purpose and Objectives The purpose of this acquisition is to procure microscope upgrades for an existing a Leica TCS SP8 STED 3 X Microscope. A Fluorescence Lifetime Imaging Microscopy (FLIM) module and 775 STED laser upgrade are required to monitor, image and visualize protein interaction in living cells. Project requirements Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to fulfill the requirement. Generic Name of Product Fluorescence microscopy microscope module; laser upgrade Purchase Description Trade name: N/A Product's brand name: FLIM Microscope module, STED 775 laser upgrade Manufacturer's name: Leica Model, type, catalog, and/or part number(s): 158001500, 158005434, 158005421, 156502140, 158001502, 158005231, 158004511, 158004760, 158005652 Salient characteristics Contractor shall provide the NINDS STS one (1) FLIM Module [Leica Item #: 158001500, 158005434, 158005421, 156502140, 158001502, 158005231, 158004511, 158004760, 158009103, 158009120] and one (1) STED 775 laser upgrade [Leica Item #: 158005652] that meets shall meet the following requirements: Leica Part NumberItem NameDescription 158001500External Chiller Air-cooled heat exchanger 158005434SMD Software Package FLIM 64 bitSoftware for acquisition of FLIM data 158005421Electronic and detector package 1 SP HybridDetector for SMD data acquisition with high time resolution 156502140Pulse picker upgrade for White Light Laser generation 2It allows to select the white light laser repetition rate 158001502SP module coolingCircuit for external cooling of the spectral module. The heat removal reduces dark noise of spectral hybrid detector leading to maximum signal-noise ratio 158005231SMD excitation like White Light LaserPackage needed to generate a synchronization signal from white light laser. The synchronization signal is a prerequisite for lifetime based measurement like FLIM 158004511notch filter setPositioned in the fluorescence detection axis. It provides additional suppression of excitation light 158004760Trigger Unit For communication between SP scan head and external. Additionally, it is used for synchronization of confocal imaging controlled by LASAF and FLIM imaging by FLIM specific software. 158009103405 nm laser couplerOptical and mechanical coupling interface for laser with pulsed 405nm for FLIM 158009120DMOD 405nm laser upgrade Continuous wave laser with wavelength 405nm for fluorescence imaging with dyes. Laser intensity is directly modulated, suitable for imaging with region of interest. 158005652STED 775 laser upgrade Laser with emission wavelength at 775 nm, output power superior at 1.5W. The mode of operation is pulsed (80MHz) with externally triggered. Quantity One (1) FLIM microscope module One (1) STED 775 laser upgrade Delivery Contractor shall delivery within six (6) weeks after receipt of order. Installation and training shall occur within four (4) weeks of delivery. Training shall be one (1) day and on-site. Contractor shall provide an original equipment manufacturer (OEM) certified service technician to perform installation and training. Delivery, installation and training must be performed at 35 Convent Drive, Room 2B912, Bethesda, MD 20892 between the hours of 8:00 am and 5:00 pm, local prevailing time, Monday through Friday. Period of Performance Contractor shall provide a one (1) year warranty that covers defects in manufacturing and excludes wear and consumable items. Installation and system-use training shall also be provided. Installation and training must be provided by a manufacturer certified service technician Anticipated Contract Type: A firm fixed price purchase order within the Simplified Acquisition threshold is anticipated. Place of Performance: The place of performance shall be the National Institutes of Health located in Bethesda, Maryland. Capability Statement: Contractors that believe that they possess the ability to provide the required equipment, warranty, and installation should submit documentation on their ability to meet each of the project requirements to the Contract Specialist. The capability statement should include 1) the total number of employees, 2) documentation of ability to provide the required equipment and warranty 3) any contractor GSA Schedule contracts by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Contractors must also provide their Company Name, DUNs number, Physical Address, and Point of Contact Information. Interested organizations are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government request that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. All capability statements sent in response to this Sources Sought Notice must be submitted to Jermaine Duncan, Contract Specialist, via email at jermaine.duncan@nih.gov before the closing date and time of this announcement. All responses must be received by the specified due date and time in order to be considered. Note: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in the response. No proprietary, classified, confidential or sensitive information should be included in your response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After review of the responses received, pre-solicitation and solicitation notices may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. The solicitation release date is pending. The Government anticipates negotiation of a firm fixed price purchase order. Contracting Office Address: 31 Center Drive Room 1B59 Bethesda, Maryland 20892 United States Place of Performance: Bethesda, Maryland 20892 United States Primary Point of Contact: Jermaine Duncan, Contract Specialist Jermaine.duncan@nih.gov Phone: 301-827-7515
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