SOLICITATION NOTICE
66 -- Purchase of a Lionheart FX automated microscope
- Notice Date
- 9/3/2017
- Notice Type
- Presolicitation
- NAICS
- #334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02RC72665-76
- Archive Date
- 9/14/2017
- Point of Contact
- Catherine Muir, Phone: (240) 276-5434
- E-Mail Address
-
muirca@mail.nih.gov
(muirca@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E144, Bethesda, MD 20892, USA. Description: National Cancer Institute (NCI), Center for Cancer Research (CCR), Radiology Oncology Branch (ROB), plans to procure on a sole source basis a Lionheart FX automated microscope that is manufactured by Biotek Instruments, Inc., Highland Park, P.O. Box 998, Winooski, Vermont 05404-0998 USA. The response close date of this notice for this requirement is in accordance with FAR 5.203(a)(1). This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1), and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 334516 and the business size standard is 1,000 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The equipment shall be delivered and installed, and training completed within 4-6 weeks of purchase order. It has been determined there are no opportunities to acquire green products or services for this procurement. The Radiation Oncology Branch (ROB) exists to plan and conduct pre-clinical and clinical research on the biologic and therapeutic effects of radiation administrated alone or in combination with other modalities of treatment; to develop novel technology and imaging based approaches for radiation oncology; to investigate the natural history of disease to understand and evaluate means of diagnostic assessment for the purpose of optimizing treatment selections; and to provide radiation therapy as well as general oncology consultations for patients admitted to other NIH Clinical Research Center (CRC) clinical services, in a collaborative approach. The Radiation Oncology Branch exists as part of the National Cancer Institute (NCI) Center for Cancer Research (CCR). The ROB designs and conducts pre-clinical and clinical research on the biologic and therapeutic effect of radiation therapy. The research clinical trials that the ROB develops and conducts involve novel technology and/or imaging based approaches to radiation therapy treatment. Within ROB Computer Tomography (CT) and Magnetic Resonance (MR) image fusion is a routine part of a patient treatment planning. The ROB also provides treatment via radiosurgery, intensity-modulated 3-D conformal radiotherapy (IMRT), real-time dose measurement, brachytherapy, and MR-guided procedures. The Contractor shall provide the following salient physical, functional, and performance characteristics, inclusive of hardware and/or software specifications, that are deemed essential to the needs of the Government: PRODUCT FEATURES/SALIENT CHARACTERISTICS The following product features/characteristics are deemed essential for this requirement: • Due to space limitations must be a compact, benchtop, standalone automated microscope performing digital widefield microscopy no more than 19" in width. • provide light tight imaging to limit light exposure during fluorescent imaging while preventing excessive leakage of gases during live cell imaging. • capable of maintaining CO2 and O2 levels from 1-19% through a module with zirconium sensor. Gas levels must be maintained by connections to standard CO2 or N2 tanks or lines and not use premixed air. Must be capable of maintaining live cell environment for an extended period of time for up to a week without perturbation of sample. • an option to perform assays in a humidity chamber exposing only the sample to humidity and not the light source and objectives. • temperature control up to 40° featuring 4-zone temperature control for stringent maintenance across the plate. Uniformity must be demonstrated and verified by an independent temperature test plate or another verified method. • dual reagent injector with dispensing accuracy of at least +/- 1µL with dispensing volume between 5 µl and 1000 µl. Tips of this dispenser must be angled to prevent damage to cell monolayer. Injectors should move to dispense liquid so that fast biology can be captured. • condensation control to prevent blurry images in long term assays. Objectives and sample plate should be maintained at same temperature. • 4 imaging modes- fluorescence, brighfield, color brightfield and phase contrast imaging. All light sources must be LED based. Fluorescence light sources must be a combination of LED and appropriate filter cube. They must be two separate components for mixing and matching for future assays. Must have at least 8 different LED light sources available. • 4-position slider for holding fluorescence light sources. Filter cubes must range from deep UV wavelengths to near-infrared. • 6-position objective turret. Must have magnifications from 1.25x to 100x. Objectives 20x and higher must feature correction collars for adjustment of height for slides, plates and • stage inserts (adaptors) for microscope slides, petri and cell culture dishes (35 mm and 60 mm dishes), T25 and T75 cell culture flasks, counting chambers, chamber slides and well plates. Software should be able to image any custom plate layout as long as the total vessel height is less than 48mm. • ability to change light cubes and objectives without disturbing sample plate for multiplexing imaging post acquisition. • laser auto focus. Must also have image-based autofocus and fixed focus option. • auto-exposure, and auto-light intensity features • Software with the ability to set partial plate exposures for two different protocols on the same plate and in the same kinetic run. • Software must have single color, multi-color, montage, time lapse, and Z-stacking imaging methods. Raw, unaltered image must be saved and exported as a 16-bit TIFF. • Software must feature post processing tools like background subtraction and deconvolution. • lead screw driven stage with at least a 0.1 µm resolution • 16-bit CCD camera with a 1.25 megapixel resolution. • option to output images as TIF, JPG, BMP, PNG and GIF. • Software with the ability to stitch images and make movies. Must output movies as MP4 or WMV • Software must provide automated cell counting, cell measurements, and image statistics. Software must also have option to provide spot counting, dual masking and intensity measurements. • 2-year warranty DELIVERY / INSTALLATION NCI, CCR, ROB 10 Center Drive, B3B405A1 Bethesda, MD 20892 TRAINING Training should occur within 1 week of receiving instrument for approximately 12 users. PAYMENT Payment shall be made in arrears after delivery, installation, inspection and acceptance, and successful completion of the required training stated above. Payment authorization requires submission and approval of invoices to the NCI Technical Point of Contact and the NIH Office of Financial Management (OFM), in accordance with the payment provisions in the order. The following clause is applicable to all Purchase Orders, Task or Delivery Orders, and Blanket Purchase Agreement (BPA) Calls: PROMPT PAYMENT (JUL 2013) FAR 52.232-25 This equipment is manufactured by Biotek Instruments, Inc. The proposed source is the only known source on the market that provides an instrument with all of the technical requirements stated in the Statement of Need. The proposed source has designed and developed the Lionheart FX automated microscopy system. The proposed equipment is a unique, one-of-a-kind instrument based on a novel, proprietary technology no similar competitive instrument exists. The proposed equipment is essential to the Government's requirement, and market research indicates there are no other companies with a similar product to meet the Government's needs. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 8:15PM EDT, on Sept. 13, 2017. All responses and questions must be in writing and faxed (240) 276-5401 or emailed to Catherine Muir, Contracting Officer via electronic mail at muirca@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid, current Entity Record, including current Representations and Certifications, in the System for Award Management (SAM) through SAM.gov. Reference: N02RC72665-76 on all correspondence.
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