SOLICITATION NOTICE
66 -- Acquisition of Biotek Lionheart FX Augmented microscopy system
- Notice Date
- 9/3/2017
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02RC72664-76
- Archive Date
- 9/14/2017
- Point of Contact
- Catherine Muir, Phone: (240) 276-5434
- E-Mail Address
-
muirca@mail.nih.gov
(muirca@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E144, Bethesda, MD 20892, USA. Description: National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Cell Biology, plans to procure on a sole source basis a Biotek Lionheart FX Augmented microscopy system that is manufactured by Biotek Instruments, Inc., Highland Park, P.O. Box 998, Winooski, Vermont 05404-0998 USA. The response close date of this notice for this requirement is in accordance with FAR 5.203(a)(1). This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1), and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 334516 and the business size standard is 1,000 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The equipment shall be delivered and installed, and training completed within 4-6 weeks of purchase order. It has been determined there are no opportunities to acquire green products or services for this procurement. The Laboratory of Cell Biology (LCB) studies the processing, transport, and metabolism of proteins and small molecules related to malignant transformation, metastasis, and multidrug resistance in cancer. The principal investigators of the laboratory, who are experts in molecular biology, genetics, biochemistry, structural biology, cellular regulation of cell growth and metabolism, resistance to anticancer drugs, and the physics of cell-matrix interactions, work on research projects related to those topics. The Multidrug Resistance Section studies the molecular basis of anticancer drug resistance, while the Transport Biochemistry Section investigates the biochemistry of energy-dependent transporters. Post-translational regulation of the tumor suppressor p53 and the roles of Wip1 in promoting cellular proliferation are the focus of the Chemical Immunology Section, while the DNA and Nucleoproteins Section is involved in computational and experimental studies of nucleic acid-protein interactions. The Biochemistry of Proteins Section studies the role of ATP-dependent proteolysis in multiple cellular processes. The Biophysics Section develops novel EM-based approaches to determine single molecule and multisubunit structures. The Tissue Morphodynamics Unit studies how normal and cancer cells modify their environments to promote normal differentiation and cancer cell metastasis. Finally, the Crystallography Section works on X-ray crystallography of membrane proteins and protein complexes. LCB also includes three Cores, one involved in 3D electron microscopy, one in molecular modeling, and one in characterization of post-transcriptional protein processing. Joint journal clubs and data presentations among some sections, and laboratory-wide research seminars facilitate the sharing of expertise and help to foster collaborations among members. LCB investigators have contributed to characterizing important cellular processes involved in the development, prevention and/or treatment of cancer. The Contractor shall provide the following salient physical, functional, and performance characteristics, inclusive of hardware and/or software specifications, that are deemed essential to the needs of the Government: PRODUCT FEATURES/SALIENT CHARACTERISTICS The following product features/characteristics are deemed essential for this requirement: • The instrument must be a benchtop system that meets the following specifications: 18.5" D, 18" W, 27.5" H in order to fit in the existing laboratory layout and fit within a standard biosafety cabinet easily for work with labile samples • light tight imaging to limit light exposure during fluorescent imaging • Environmental control cover which provides light tight imaging. • able to perform automated digital microscopy • CO2 and O2 control maintained through module with zirconium sensor. • humidity chamber temperature control up to 40° featuring 4-zone temperature control for maintenance across the plate. • condensation control to prevent blurry images. Objectives and sample plate to be maintained at same temperature. • the ability to change light cubes and objectives without disturbing sample plate for multiplexing imaging post acquisition. • laser auto focus, image-based autofocus, auto-exposure, and auto-light intensity features • the ability to set partial plate exposures for two different protocols on the same plate and in the same kinetic run. • bright field, color bright field, phase contrast and fluorescence imaging modes • single color, multi-color, montage, time lapse, and Z-stacking imaging methods • a 4-filter cube capacity and a 6-position objective turret • a lead screw driven stage with at least a 0.1 µm resolution • 16-bit CCD camera with a 1.25-megapixel resolution. • 4x phase, 10x phase, 20x phase, and 40x objectives. Objectives must feature correction collars for adjustment of height for slides, plates and tissue culture vessels. • option for 60x oil objective and 100x oil objective • at least 8 different LED light sources available. • filter cubes for fluorophores from DAPI to Cy7 range. • output raw images at least 16-bit TIFF • option to output images as TIF, JPG, BMP, PNG and GIF. • output movies as MP4 or WMV • stage inserts (adaptors) for microscope slides, petri and cell culture dishes (35 mm and 60 mm dishes), T25 and T75 cell culture flasks, counting chambers, chamber slides and well plates • an option for reagent injector with dispensing accuracy of at least +/- 1µL with dispensing volume between 5 µl and 1000 µl • Software which must provide automated cell counting, cell measurements, and image statistics DELIVERY / INSTALLATION Delivery Address: NIH/NCI Lab of Cell Biology 37 Convent Drive Bldg. 37/room 2106 Bethesda, MD 20892 USA The equipment shall be delivered and installed within 4-6 weeks of purchase order award. TRAINING The system must include installation, familiarization, and a customer training class for no less than three (3) operators. PAYMENT Payment shall be made in arrears after delivery, installation, inspection and acceptance, and successful completion of the required training stated above. Payment authorization requires submission and approval of invoices to the NCI Technical Point of Contact and the NIH Office of Financial Management (OFM), in accordance with the payment provisions in the order. The following clause is applicable to all Purchase Orders, Task or Delivery Orders, and Blanket Purchase Agreement (BPA) Calls: PROMPT PAYMENT (JUL 2013) FAR 52.232-25 This equipment is manufactured by Biotek, Inc. The proposed source is the only known source on the market that provides an instrument with all of the technical requirements stated above. Biotek, Inc. has designed and developed the Lionheart FX automated microscopy system. The proposed equipment is a unique, one-of-a-kind instrument based on a novel, proprietary technology no similar competitive instrument exists. The proposed equipment is essential to the Government's requirement, and market research indicates there are no other companies with a similar product to meet the Government's needs. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 6:00PM EDT, on Sept. 13, 2017. All responses and questions must be in writing and faxed (240) 276-5401 or emailed to Catherine Muir, Contracting Officer via electronic mail at muirca@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid, current Entity Record, including current Representations and Certifications, in the System for Award Management (SAM) through SAM.gov. Reference: N02RC72664-76 on all correspondence.
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- SN04660475-W 20170905/170903230040-2dc23c54aa3445bb28c6aef73583efa3 (fbodaily.com)
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