SOLICITATION NOTICE
A -- B-Cell Epitope Discovery and Mechanisms of Antibody Protection
- Notice Date
- 5/7/2018
- Notice Type
- Presolicitation
- NAICS
- 541713
— Research and Development in Nanotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Office of Acquisitions, 5601 Fishers Lane, 3rd Floor, MSC 9821, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- BAA-NIAID-DAIT-NIHAI201800001
- Archive Date
- 6/6/2018
- Point of Contact
- MyLinh T. Pham, Phone: 2406695145, Liem T. Nguyen, Phone: 240-669-5144
- E-Mail Address
-
phamm@exchange.nih.gov, lnguyen@niaid.nih.gov
(phamm@exchange.nih.gov, lnguyen@niaid.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This program will support the identification of human B cell epitopes derived from pathogens or elicited by vaccines against pathogens, coupled with basic studies to understand protective immunity mediated by antibodies and, when applicable, pathological consequences of antibody responses; as well as the identification of human B cell epitopes derived from self-antigens, coupled with basic studies to understand the role of autoantibodies in autoimmune disease. Investigators may utilize recent technological advances for epitope discovery, such as high throughput single cell B cell analysis, or systems serology; or develop new or improved technologies, including computer-based B cell epitope prediction algorithms, for the identification of novel B cell epitopes. Epitope discovery methods may include basic studies in appropriate animal models, but human samples will be required to validate the epitope as a target of antibody-mediated protective immunity and to understand the mechanisms by which the antibodies induce immune protection or contribute to pathogenesis. Supported investigators will be required to attend an annual program review meeting at NIH and submit their epitope information to the Immune Epitope Database and Analysis Resource (www.iedb.org). Contracts awarded in FY09 and in FY14 have been productive and minor changes are anticipated for the FY19 renewal. The renewed solicitation contains a programmatic emphasis on inclusion of mechanisms of antibody-mediated protection not explained by neutralization by antibody (e.g., antibody-dependent cellular cytotoxicity, antibody-dependent phagocytosis, and complement-dependent cytotoxicity) and for the first time includes the study of autoimmune responses and all transplantation. It is anticipated that three to five cost-reimbursement, completion type contracts will be awarded for a five-year period of performance beginning on or about August 30, 2019. NIAID estimates that the average annual total cost (direct and indirect costs combined) is $1.0M per contract. However, it is anticipated that the total cost for the award(s) may vary depending upon the scope of the project and the technical objectives of the award(s). The length of time for which funding is requested should be consistent with the nature and complexity of the proposed research. In no event shall the period of performance proposed by an offeror exceed five years. Any responsible offeror may submit a proposal which shall be considered by the Agency. This BAA will be available electronically on/about May 22, 2018 and may be accessed through FedBizOpps http://www.fedbizopps.gov/. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIAID/BAA-NIAID-DAIT-NIHAI201800001/listing.html)
- Place of Performance
- Address: 5601 Fishers Lane, MSC 9821, Rockville, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN04912685-W 20180509/180507230546-a62ab139bdef7a1613c0a7a5d64553d9 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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