SOURCES SOUGHT
B -- Clinical, Laboratory and Biomedical Characterization of California Children with Pediatric Acute-Onset Neuropsychiatric Syndrome
- Notice Date
- 9/7/2018
- Notice Type
- Sources Sought
- NAICS
- 611310
— Colleges, Universities, and Professional Schools
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- NIHDA-2018-00485
- Archive Date
- 9/29/2018
- Point of Contact
- Christopher A. Weaver, Phone: 301.827.5871
- E-Mail Address
-
christopher.weaver@nih.gov
(christopher.weaver@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Introduction: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. North American Industry Classification System (NAICS) Code: The NAICS code applicable to this requirement is 611310 - Colleges, Universities, and Professional Schools - and the associated small business size standard of $27.5 million dollars. Background Information: The National Institute of Mental Health (NIMH), Section on Behavioral Pediatrics (SBP), Intramural Research Program conducts clinical research on a variety of childhood behavioral problems including research to identify both biological and clinical factors which influence the onset and expression of behavioral symptoms and to develop more effective treatment and prevention strategies for childhood disorders. Currently, SBP's research is focused on understanding the etiology, pathophysiology and clinical features of obsessive compulsive disorder, including acute-onset subtypes. Purpose and Objectives of the Acquisition: This potential purchase order will allow a board-certified pediatrician and rheumatologist to consult on detailed clinical information and crucial biological specimens from children living in California who have an abrupt onset of neuropsychiatric symptoms. The phenotypic profiles and biospecimens of these children will be compared against those obtained from children living in four other geographically diverse sites (Massachusetts, Arizona, Minnesota, and Virginia). The California patient profiles also will be compared against data and samples previously obtained in the NIMH Intramural Research Program in order to ascertain temporally-related changes in clinical presentation, microbial virulence and host reactivity. Contractor Requirements (Scope of Work): The contractor requirements may include, but are not limited to the following: The clinical information and biological specimens provided shall help the SBP accomplish four specific aims: 1. Identify unique and distinctive clinical, paraclinical and laboratory features of acute-onset neuropsychiatric symptoms among children meeting criteria for PANS (Pediatric Acute-onset Neuropsychiatric Syndrome). 2. Determine the role of environmental pathogens, such as Group A streptococci, in disease onset and recurrences. 3. Investigate factors influencing host susceptibility and resistance. 4. Elucidate the role of immune dysfunction in PANS or its subgroups, including cases of Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infection (PANDAS). Additionally, the contractor shall provide detailed clinical, laboratory and biomedical data from children living in California who meet diagnostic criteria for PANS. The criteria include 1) Abrupt, dramatic onset of obsessive-compulsive disorder (OCD) or severely restricted food intake AND 2) Concurrent presence of additional neuropsychiatric symptoms, with similarly severe and acute onset, from at least two of the following seven categories: Anxiety (particularly separation anxiety); Emotional lability and depression; Irritability, aggression, and/or severely oppositional behaviors; Behavioral (developmental) regression; Deterioration in school performance (due to inattention, concentration difficulties, memory deficits, or othims); Sensory or motor abnormalities; or Somatic signs and symptoms, including sleep disturbances, enuresis, or urinary frequency. Symptoms are not better explained by a known neurologic or medical disorder, such as Sydenham chorea, systemic lupus erythematosus, Tourette disorder, or others. Anticipated Period of Performance: It is anticipated that the period of performance for this requirement will be one (1) twelve-month base period. Capability Statement: Respondents shall: 1. Provide a capability statement that clearly describes their ability to provide the requirements specified in this notice. 2. Provide sufficient details of the respondent (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information. 3. Provide the respondent DUNS number, organization name, address, point of contact, and size and type of business e.g., 8(a), HubZone, etc. pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. Also, respondents are encouraged to provide their opinions about the difficulty and/or feasibility of the potential requirement or proposed acquisition, possible solutions and approaches that may currently exist in the marketplace, and information regarding innovative ideas or concepts. Submission Instructions: One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8.5" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The information submitted must be in outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone, and e-mail addresses. All responses to this notice must be submitted electronically to Christopher Weaver, Contracting Officer via email at christopher.weaver@nih.gov. Email subject line: "Response to No. NIHDA-2018-00485 Clinical, Laboratory and Biomedical Characterization of California Children with Pediatric Acute-Onset Neuropsychiatric Syndrome". Facsimile responses are NOT accepted. The response must be received on or before September 14, 2018 by 3:00 pm Eastern Time. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/NIHDA-2018-00485/listing.html)
- Record
- SN05079122-W 20180909/180907231427-b0ca03ecb319704a574f2960e84b140d (fbodaily.com)
- Source
-
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