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FBO DAILY - FEDBIZOPPS ISSUE OF AUGUST 21, 2019 FBO #6480
SOLICITATION NOTICE

66 -- Purchase Brand Name Or Equal 4D-Nucleofector instrument

Notice Date
8/19/2019
 
Notice Type
Combine Synopsis/Solicitation
 
NAICS
334516 — Analytical Laboratory Instrument Manufacturing
 
Contracting Office
4041 Powder Mill Road Beltsville MD 20705
 
ZIP Code
20705
 
Solicitation Number
FDA-RFQ-1204596-FO
 
Response Due
8/26/2019
 
Point of Contact
Sarah Hussain, Contract Specialist, Phone 2404023796
 
E-Mail Address
sarah.hussain@fda.hhs.gov
 
Small Business Set-Aside
N/A
 
Description
The Division of Applied Veterinary Research (DAVR) in the FDA Center for Veterinary Medicine, Office of Research, requires scientific equipment to transfer RNA/DNA directly into the nucleus of immortalized cell lines and primary cells/stem cells. Primary and stem cells are notoriously difficult, if not impossible, to transfect using cationic lipid mediated methods (Fugene, Lipofectamine, etc.). FDA will perform an experimental technique that requires the transfer of RNA and DNA directly into the nucleus of a cell to cause double stranded DNA breaks. This will allow for the introduction of nucleotide insertions or deletions, and for the introduction of exogenous DNA sequences into targeted genomic regions. We will also transfer double stranded oligodeoxynucleotides (dsODNs) into the double stranded breaks in the genome. These dsDNA sequences must be delivered directly into the nucleus of the cell, and cationic lipid mediated methods will not work. NOTE: THIS NOTICE WAS NOT POSTED TO FEDBIZOPPS ON THE DATE INDICATED IN THE NOTICE ITSELF (19-AUG-2019); HOWEVER, IT DID APPEAR IN THE FEDBIZOPPS FTP FEED ON THIS DATE. PLEASE CONTACT 877-472-3779 or fbo.support@gsa.gov REGARDING THIS ISSUE.
 
Web Link
Link To Document
(https://www.fbo.gov/spg/HHS/FDA/DCASC/FDA-RFQ-1204596-FO/listing.html)
 
Record
SN05409979-F 20190821/190819230034 (fbodaily.com)
 
Source
FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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