SOLICITATION NOTICE
66 -- High resolution and high content Bio-imager - Purchase Description
- Notice Date
- 9/5/2019
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- NIH-NINDS-CSS-19-5336844
- Archive Date
- 9/27/2019
- Point of Contact
- Danny Cohn, Phone: 3014027111
- E-Mail Address
-
danny.cohn@nih.gov
(danny.cohn@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- FAR 52.212-5 - Additional Applicable FAR Provisions FAR 52.212-1 - Instructions to Offerors FAR 52.204-24 & FAR 52.204-25 Purchase Description This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is NIH-NINDS-CSS-19-5336844 and the solicitation is issued as a request for quote (RFQ). This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5-Simplified Procedures for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2019-03 thru July 12, 2019. The associated NAICS code 334516, "Analytical Laboratory Instrument Manufacturing" and the small busisess size standard 1000 employees. This requirement is full and open with no set-aside restrictions. Contract Type: A firm-fixed price type contract is contemplated for this requirement. Background Information and Objective: The NINDS NTDU develops and utilizes automated medium-high throughput assays to identify potential novel therapeutic compounds. In this capacity, the lab can screen libraries of small compounds in both rodent and human neuronal cell culture models of neurodegenerative disorders like ALS motor neuron disease, Alzheimer's and Parkinson's disease and neuronal cell models of neurologic infections from agents like HIV, Zika virus, human endogenous retroviruses and even Ebola virus. The Lab requires a high speed and high content image acquisition and analysis system capable of acquiring and analyzing hundreds/thousands of photomicrographs from neuronal cultures which have been exposed to various chemical and biological toxins to represent or mimic neurologic disease. Statement of Need and Purpose: The purpose of this acquisition is to acquire a high resolution and high content laser based confocal molecular bio-imager instrument for the Neuro Therapeutics Development Unit, (NTDU), Translational Neuroscience Center, NINDS. We will incorporate the use of the new imager into our screening and bio-analysis workflow in order to achieve our goals of identifying, characterizing and developing of new and novel therapeutics for neurological diseases and infections of the nervous system. This work involves high resolution acquisition and high content analysis of our human neuronal cultures, which mimic the neurodegenerative states that are under investigation. Salient Characteristics: High Content Analysis (HCA) Platform with multiple laser illumination, Confocal 3D acquisition, a fast, automated cellular imaging and analysis platform designed for quantitative microscopy and phenotypic screening. The instrument shall incorporate robotics to facilitate transfer of culture plates from our preexisting CytoMat 2C to a laser based confocal bio-imager. This systemshall include 4X through 40X objectives, an environmental chamber with controlled humidity to facilitate live cell imaging and analysis, laser-based autofocus, high resolution phase contrast imaging in addition to fluorescence based imaging. Minimum system specifications and characteristics shall be as follows: •Bio-imager system must have a multi-color Laser-based imaging system •System must image in widefield and confocal modes for high resolution microscopy of neuronal cultures, iPSC spheroids and cerebral organoids •System must have either the latest high resolution cooled CCD camera or sCMOS camera with greater than ~75% quantum efficiency. •System must have 4X, 10X, 20X and 40X objectives. Additional objectives, such as 1-2X or 60X objectives maybe added at later date. •System must have laser based autofocus methods to accommodate a broad range of sample types and consumables on the platform. •System must have multiple Imaging modes, both widefield and confocal modes including deconvolution, time series & maximum projection. •System must have automated 3D imaging and volumetric image analysis combined with simultaneous multi-threaded parallel processing and automatic storage in a Microsoft SQL Database. •System must have environmental control for Live-Cell options: CO2 control and/or CO2-O2 control. •System must have Imaging capability with multiple wavelengths from the UV to near IR wavelength ranges. •System must be capable of Imaging in SBS standard microplates, including 6 well through 96 well plates, plus 384 and 1536 well plates. Imaging in chamber slides and standard glass slide modes. •System must have confocal mode settings for collecting Z-stacks of spheroids, cerebral organoids or other thick, asymmetrical objects. •System should function in manual microscope mode - allows the user to switch objectives, filters, focus, fields of view on the fly as would be conducted in a manual system. •System should have high NA air objectives that allow for high resolution imaging in all wells of the plate. •System includes LED based Transmitted Light Capabilities •System must be capable of a fully integrated walk-away software package that allows the user to analyze images with pre-built application modules, customize algorithm settings with a custom module editor and write scripts to control all functions of the hardware and software to create fully customizable high content image acquisition and analysis. •System must include 2D on-the-fly and 3D deconvolution software capabilities. •System must have High resolution analysis software-integrated for image acquisition and data analysis. The analysis must be able to provide quantitative image analysis in high resolution phase contrast images as well as fluorescent images of human neurons. Analysis of morphologic parameters in high resolution images of human neuronal processes and dendritic spines is required. •System must come with two (2) licenses for the analysis software. •Extensive technical training in use of new acquisition and analysis software onsight following installation is required. •System must include a Robotic Plate Handler with hotels to store up to 88 plates. •System must include integration of Bio-imager with existing NINDS Cytomat Incubator •Robotic plate handler integration must include dynamic scheduling software with unlimited expansion •Inside delivery Please see the attached Purchase Description for more details. Other Applicable Provisions and Instructions 1)The provision at FAR clause 52.212-1, Instructions to Offerors - Commercial Items, applies to this acquisition and is attached. 2)The provision at FAR clause 52.212-2, Evaluation - Commercial Items, applies to this acquisition. (a)The Government will award a fixed price contract resulting from this solicitation to the lowest price technically acceptable (LPTA) offer. To be technically acceptable, the offer must satisfy the requirements outlined in the Purchase Description including salient characteristics, quantity, delivery and warranty requirements. (b)A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer's specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiationsafter its receipt, unless a written notice of withdrawal is received before award. 3)The Offerors to include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications-Commercial Items, with its offer. 4)The FAR clause at 52.212-4, Contract Terms and Conditions - Commercial Items, applies to this acquisition and is incorporated by reference. 5)FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items, applies to this acquisition. See attached document, "FAR 52.212-5 Applicable Clauses", for clauses applicable to this acquisition. 6)The provision of FAR Clause 52.204-24, is applicable to the solicitation and attached. Offerors are requested to complete and sign this attached provision and include with any submitted quotation. 7)FAR Clause 52.204-25, is applicable to the solicitation and attached. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. Please be advised that the National Institute on Neurological Disorders and Stroke (NINDS) is an Institute within the National Institutes of Health (NIH), which is a Federal agency. Your mass-market commercial and/or license agreement may include provisions that are customarily found in the commercial sector but which are not appropriate for a contract with a Federal agency. Specifically, NINDS considers any provision in your mass-market commercial and/or license agreement to be inappropriate and unenforceable that: (1) Contravenes a right granted NINDS under U.S. copyright law (e.g., fair use, right to archive, copying for interlibrary loan), (2) Violated the Federal Acquisition Regulation or other Federal law (e.g., Antideficiency Act, Principles of Federal Appropriations Law), (3) Departs from reasonable consumer expectations and was not disclosed by the Licensor prior to agreement, or (4) Violates fundamental public policy. NINDS shall assume that you are in agreement with the statements herein if you submit a quotation. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." There are no additional contract requirement(s) or terms and conditions applicable to this acquisition. All responses must be received by 1:00 P.M. EST on September 12, 2019 and reference solicitation number NIH-NINDS-CSS-19-5336844. Responses must be submitted electronically to danny.cohn@nih.gov. Fax responses will not be accepted.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/NIH-NINDS-CSS-19-5336844/listing.html)
- Place of Performance
- Address: 6001 executive blvd, Rockville, Maryland, 20852, United States
- Zip Code: 20852
- Zip Code: 20852
- Record
- SN05432260-W 20190907/190905231015-15108ceb82c29a6a1a3556660dab019d (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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