SOURCES SOUGHT
66 -- Maxtwo multiwell HD-MEA CMOS-based multiwell HD-multi-electrode array (MEA) platform
- Notice Date
- 5/13/2020 8:50:30 AM
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- NIMH20003849
- Response Due
- 5/22/2020 9:00:00 AM
- Archive Date
- 05/22/2020
- Point of Contact
- Thien Nguyen, Phone: 3018270914
- E-Mail Address
-
Thien.Nguyen2@nih.gov
(Thien.Nguyen2@nih.gov)
- Small Business Set-Aside
- SBA Total Small Business Set-Aside (FAR 19.5)
- Description
- Federal Business Opportunities (FBO) SOURCES SOUGHT NOTICE � Solicitation Number: NIMH20003849 � Title:� Maxtwo multiwell HD-MEA CMOS-based multiwell HD-multi-electrode array (MEA) platform. � Classification Code:� 66 -- Instruments & laboratory equipment � NAICS Code:� 334516 � Analytical Laboratory Instrument Manufacturing Description:� � This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background: Our laboratory will continue to generate iPSC-derived neurons and the availability of this type of instrument, which is currently non-existent within the NIMH IRP, is vitally important. Recent advances in multi-electrode array technology now enable the rapid characterization of both intrinsic and evoked neuronal firing(Kizner, Fischer, and Naujock 2019; Clements 2016; Kapkaeva et al. 2018). Sophisticated spatial measures are now possible across numerous neurons growing together in culture. These measures provide precise measures of synchronicity of firing in neurons growing in the same culture well, providing remarkably detailed information about neuronal circuits and their properties in vitro(Kapkaeva et al. 2018). This contract will support the acquisition, set-up, and optimization of a cutting-edge multi-electrode array system, the MaxTwo, produced by Maxwell Biosystems. This is a unique product that has 26,000 electrodes per well whereas other products available on the market offer no more than 64 electrodes per well. The higher electrode density is essential for our planned experiments, which require an accessible, reliable, and high-throughput platform for measuring excitability, networking, and circuitry in iPSC-derived neurons. This platform will allow collaborating laboratories to determine the cell-autonomous impact of neuropsychiatric risk alleles, test for rescue through pharmacologic and genetic manipulation, and screen large molecular libraries for novel therapeutics.� Purpose: Induced pluripotent stem cell (iPSC)-derived neural cells offer a powerful human model system for the functional and experimental study of alleles that confer risk of neuropsychiatric disorders (Dolmetsch and Geschwind 2011; K. J. Brennand et al. 2012). Our lab aim to establish a high-throughout platform for characterizing the electrophysiological properties of iPSC-derived neurons and neuronal circuits. This platform will facilitate experimental studies of iPSC-derived neurons, functional characterization of risk alleles, and screening for novel therapeutics, permitting a comprehensive approach for studying neuronal activity under various conditions. Project requirements: The Contractor shall provide one (1) MaxTwo System (Brand Name) or equal to the following specifications: MaxTwo System including software MaxLab Live Basic, perpetual license MaxTwo 6-Well-Plate Starter Package (including 1st Year MX2-SUB-6W; 12 MX2-S-�� 6W plates) Recording PC (Recording computer with MaxLab Live preinstalled; Intel Core i7-8700k 6C; 16GB DDR4; HDD 4TB 7200 RPM SATA; NVIDIA Quadro P400 2GB; (3)mDP, 2nc GbE NIC; 24inch monitor; Warranty for MX-PC is two (2) years) On-site training (System setup and installation; Training and assisted tutorials; One day on-site (including travel and lodging expenses) MaxLab Live ActivityMap Assay (Extract whole sample activity map label-free (firing rate, amplitude); Track whole sample activity map development long-term) MaxLab Live NetworkConnectivity Assay (Smart population recording of neuronal networks; Identify and track neuronal bursting features; Extract functional network connectivity and synchrony) MaxLab Live AxonTracking Assay (Identify and track single neurons; Extract axonal arbors; Calculate axonal action potential propagation velocity) MaxLab Live Stimulation Assay (Enable electrical stimulation on any electrode; Selectively stimulate single cells) Digital Gas Mixing System (Tokai-Hit GM-2000; Stand alone digital gas mixing system; Gas cylinder: 100% CO2; CO2 concentration: Fixed 5.0% TH-GM-2000) Salient characteristics: MaxWell Biosystems� MaxTwo is a CMOS-based multiwell HD-multi-electrode array (MEA) platform. It has all the capabilities of MaxOne � it captures high-quality signals at sub cellular resolution from long-term culture experiments. Electrical stimulation protocols can also be performed. MaxTwo multiwell HD-MEA system allows for easy and vibration-free insertion of the multi-well MEA. The MaxTwo mainframe is an incubator allowing cells to have a proper environment during recording. It is designed for integration with automation systems. Overall, MaxTwo is a powerful electrical imaging system for drug discovery, safety pharmacology, and iPSC phenotyping applications. Other characteristics:� � 26,400 electrodes (9.3�5.45 sq-?m, 17.5 ?m pitch) 1024 low-noise readout channels 32 stimulation channels Large sensor area (3.85�2.10 sq-mm) Switch-matrix technology for flexible array reconfiguration Non-invasive, label-free High-resolution activity map Axonal action potential propagation tracking � Anticipated Period of Performance: Deliver 60-90 days after award Capability statement /information sought: Contractors that believe that they possess the ability to provide the required equipment, should submit documentation on their ability to meet each of the project requirements to the Contract Specialist. The Contractor should directly and specifically state in the, capabilities statement, which project requirements can be meet and/or supplied. The Contractor must also provide their� DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to two (2) page limit.� The 2-page limit does not include the cover page or executive summary. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist.� Facsimile responses are NOT accepted. The response must be submitted to Thien Nguyen, Contract Specialist, at Thien.Nguyen2@nih.gov. and Valerie Whipple, Contracting Officer, at Valerie.Whipple@nih.gov The response must be received on or before May 22, 2020 at 12 pm, Eastern Time. � �Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/f9682a23db074022b5d3fada9dd99150/view)
- Place of Performance
- Address: Bethesda, MD 20892, USA
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN05656853-F 20200515/200513230200 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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