SOURCES SOUGHT
R -- Custom Radiosynthesis of PET Ligands and Use of PET Facility
- Notice Date
- 7/8/2021 11:35:21 AM
- Notice Type
- Sources Sought
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- 75N95021Q00289
- Response Due
- 7/22/2021 10:00:00 AM
- Archive Date
- 08/06/2021
- Point of Contact
- Shaun Rostad, Phone: 3014436677, Josh Lazarus, Phone: 3014436677
- E-Mail Address
-
shaun.rostad@nih.gov, josh.lazarus@nih.gov
(shaun.rostad@nih.gov, josh.lazarus@nih.gov)
- Description
- DESCRIPTION: The National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) and National Institutes of Health (NIH) is seeking Capability Statements from BOTH Other than Small Business and Small Business organizations with the demonstrated capability of providing service to support the NIDA-IRP Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit with Positron Emission Tomography compound radiosynthesis, the required instruments, supply of animals and housing of animals. This is a Sources Sought Notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified business sources; (2) the availability of capable Small Businesses; HUBZone Small Businesses; Service-Disabled, Veteran-Owned Small Businesses; 8(a) Small Businesses; Veteran-Owned Small Businesses; Woman-Owned Small Businesses; or Small Disadvantaged Businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. The established NAICS code is 541690, Other Scientific and Technical Consulting Services. The U.S. Small Business Administration establishes a size standard for 541690 as $16.5 million in annual sales or less. BACKGROUND: The NIDA IRP Neuroimaging Research Branch (NRB) neuroscientists� research requires in vivo imaging of the brain and its molecular processes in a way that parallels human imaging research. The purpose of this acquisition is to acquire a service contract to support the NIDA-IRP Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit. PURPOSE AND OBJECTIVES: Positron Emission Tomography (PET) is a non-invasive imaging technique that enables picomolar detection (i.e. the highest sensitivity among all non-invasive imaging modalities available) of molecular processes in a living animal. PET compound radiosynthesis requires dedicated instrumentation and skillset which the NIDA-IRP does not have. The objective of this contract is to: 1) prepare custom radiosynthesis of specific derivatives either with F18 or C11 on a weekly basis, 2) obtain an estimated 300 rats and/or mice (per contract year), 3) house said animals for the duration of the studies and 4) allow NIDA researchers to have access (approximately 50 hours total per year) to a small animal PET scanner to perform imaging of radiotracer distribution and occupancy in the rodent brain. The custom radiotracers will be utilized in ongoing experiments of NRB�s Molecular Neuropsychopharmacology Unit. The objective is to synthesize several radiotracer derivatives, labeled with either F18, C11 or another radioisotope that will bind various targets. There is a specific need to have these PET tracers synthesized in close vicinity to NIDA-IRP so that we can have them available for immediate use in PET imaging experiments. Due to their half-life (most commonly used radiotracers: 110 minutes for F18- and 20 min for C11-labeled PET tracers) NIDA needs a facility to be within 2 miles of the NIDA-IRP so that the PET tracers can be quickly transported for immediate use. The NIDA-IRP address is 251 Bayview Blvd, Baltimore, MD 21224. GENERAL REQUIREMENTS: Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities not otherwise provided by the Government as needed to perform the Statement of Work below: Task 1: The Contractor shall prepare radiosynthesis, including custom radiosynthesis, of specific derivatives using either C11 or F18 or other radioisotopes, as requested by the Government. Task 2: The Contractor shall supply animals (e.g. mice or rats) to NIDA Researchers to use in the experiments. Task 3: The Contractor shall provide food and housing of the small animals for the duration of each experiment. It is estimated that animals will need housing for up to approximately 3 weeks. Task 4: The Contractor shall provide NIDA researchers with access to a small animal PET scanner to perform imaging of radiotracer distribution and occupancy in the rodent brain. SPECIFIC REQUIREMENTS: Specifically, the Contractor shall: For Task 1: Prepare routine and custom radiosynthesis compounds in accordance with the type, amount and required date of delivery of radiochemical specified in the Government�s request. The Government will give a lead time of at least 2-3 weeks estimated per request. Notify the Government when the synthesized ligands are available for use within five minutes of completing synthesis. For Task 2: Provide the Government with rats or mice as specified by the Government (an estimated 300 animals per contract year) for use in experiments. For Task 3: Provide housing to each animal for approximately up to 3 weeks. Animals will be requested by the Government by the amount, which will vary by experiment, and will be specified at the time of the request. For Task 4: Provide NIDA researchers with access to a small animal PET scanner during the period of performance (an estimated 50 hours required per contract year). Provide all electronic data files produced from the PET scans to the Government within twenty-four hours after scanning is complete. KEY PERSONNEL: A radiochemist is required for the synthesis of radiotracers. INSTRUCTIONS: Respondents must provide clear and convincing documentation of their capability and experience with providing the personnel and services as specified in the tasks above. Also, information must be provided in sufficient details of the respondents� (a) staff expertise, including their availability, experience, formal and other training; (b) current capability to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and other management capability; and (e) examples of prior completed Government contracts, references, and other related information. Each capability statement must include the respondent�s� DUNS number, organization name, and address. Each response should include the technical and administrative points of contact, including names, titles, addresses, telephone numbers, and e-mail addresses. The capability statement should clearly identify the size and type of business (e.g., 8(a), HubZone, Non-Profit, Other Than Small Business, etc.), pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in an outline format that addresses each of the elements of the project requirement and in the capability statement paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) pages.� The 10-page limit does not include the cover page, executive summary, resumes, or references, if requested. Any business concerns that believe they possess the capability necessary to successfully undertake the work described above must SUBMIT CAPABILITY STATEMENTS ELECTRONICALLY to the Contract Specialist, Shaun Rostad at Shaun.Rostad@nih.gov, NO LATER THAN 1:00 p.m. EST on July 22, 2021. The Subject line for the submission should include this Sources Sought Number and organization name. NIDA will not accept paper or faxed capability statements. THIS NOTICE IS NOT A REQUEST FOR PROPOSALS.� This notice is for information and planning purposes only and does not commit the Government to any contractual agreement. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. CONFIDENTIALITY. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
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-
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- Record
- SN06055839-F 20210710/210708230133 (samdaily.us)
- Source
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