SPECIAL NOTICE
Q -- Investigating biologic effects of pesticides using an untargeted metabolomics approach in the Biomarkers of Exposure and Effect in Agriculture study
- Notice Date
- 7/12/2021 9:06:22 AM
- Notice Type
- Special Notice
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- NIH NCI ROCKVILLE MD 20852 USA
- ZIP Code
- 20852
- Solicitation Number
- 75N91021Q00151
- Response Due
- 7/22/2021 9:00:00 AM
- Archive Date
- 08/06/2021
- Point of Contact
- Miguel Diaz, Phone: 2402765439
- E-Mail Address
-
miguel.diaz@nih.gov
(miguel.diaz@nih.gov)
- Description
- National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Occupational and Environmental Epidemiology Branch (EEB) seeks to procure samples for a study of lymphoid malignancies, on a sole source basis, from the H. Lee Moffitt Cancer Center & Research Institute of 13131 USF Magnolia Drive, Tampa, FL 33612. This acquisition will be processed under FAR Part 12 � Acquisition for Commercial Items and will be made pursuant to the authority in FAR 13.106-1 (b)(1)(i) using simplified acquisition procedures for commercial acquisitions.� The North American Industry Classification System code is 541990 and the business size standard is $15.0M. The purpose of this acquisition is to conduct untargeted metabolomic analysis of plasma samples collected from pesticide applicators and non-farming controls in the Agricultural Health Study population. Previous investigations within the Agricultural Health Study have provided evidence of associations between occupational use of several pesticides and increased risk of hematological malignancies. However, biological mechanisms underlying these associations are not well-understood, with some pesticides shown to exhibit genotoxic and pro-oxidant effects in cell- and animal-based models. Ongoing investigations in the Biomarkers of Exposure and Effect in Agriculture study, a molecular subcohort within the Agricultural Health Study, are being conducted to examine associations between use of certain pesticides and candidate biomarkers (e.g., oxidative stress markers) known to be involved in specific mechanisms implicated in the development of hematological malignancies. Beyond investigations of individual biomarkers, recent advances in the omics technology provide a powerful and comprehensive means of studying various environmental exposures and their potential mechanisms of action without pre-defined hypotheses. In particular, metabolomics is the systematic profiling of low-molecular-weight chemicals and intermediates of metabolic processes. Utilization of high-throughput, untargeted metabolomic platforms allows simultaneous assessment of a broad range of exogenous and endogenous metabolites in biological samples, which may provide new insights into the complex biological pathways mediating the relationship between pesticide exposure and cancer risk. Thus, to further address the biological plausibility of the role of certain pesticides in hematological cancer development, we propose to conduct an untargeted metabolomic analysis of plasma samples from pesticide applicators with detailed records of exposure history as well as non-farming controls in the Biomarkers of Exposure and Effect in Agriculture study. Using an untargeted approach to characterize biochemical alterations related to pesticide use, this proposed research complements and extends our previous efforts targeting specific biomarkers and has the potential to identify novel metabolic intermediates and pathways through which pesticides may contribute to carcinogenesis.� The primary objective of this study is to investigate the metabolomic profiles associated with occupational exposure to pesticides that have been previously associated with increased risk of hematological malignancies in the Agricultural Health Study. Using an untargeted approach to characterize biochemical alterations related to pesticide use, this work can provide evidence for the biological plausibility between these exposures and development of hematological malignancies. The Contractor shall perform untargeted metabolomic profiling of plasma samples from individuals with detailed exposure records of pesticides previously associated with risk of hematological malignancies as well as non-farming controls in the Biomarkers of Exposure and Effect in Agriculture study. The contractor shall perform the following tasks: Document the receipt of all plasma samples in a MS Excel file with the unique ID of each sample Conduct high-performance untargeted metabolomic analysis using liquid chromatography-fourier transform mass spectrometry (LC-FTMS) for each sample submitted Record metabolomic analysis results, test date, batching information, and quality control data (if applicable) Provide NCI investigators with a copy of the metabolomic analysis results upon completion. The Icahn School of Medicine at Mount Sinai is an international leader in medical and scientific training, biomedical research, and patient care. The laboratory at the Icahn School of Medicine at Mount Sinai uses cutting-edge technology, including a high-resolution mass spectrometry metabolomics platform, to measure a wide range of environmental exposures and metabolic products. Using this high-throughput methodology, researchers at the Icahn School of Medicine at Mount Sinai have shown that it is possible to measure thousands of chemicals in a single human blood sample in a cost-effective manner, and this has led to advances in exposome research and provided mechanistic insights into disease processes. The Icahn School of Medicine at Mount Sinai has published multiple papers on metabolomics and previously analyzed several molecular epidemiologic studies and cohorts. Importantly, their metabolomics platform is particularly suitable for analyses of environmental exposures and has been previously applied to analyses of plasma samples in several molecular epidemiologic studies of occupational and environmental exposures conducted at our branch, including investigations of metabolic profiles associated with air pollution constituents, e-waste occupational exposures, as well as chemicals related to hematological and other malignancies (e.g., trichloroethylene). Furthermore, the Icahn School of Medicine at Mount Sinai has unique and specialized expertise in laboratory, bioinformatics, and statistical analyses of the data NCI aims to generate for this study. Lastly, utilizing a single source for plasma measurements minimizes the sample volume requirements and eliminates additional shipping and processing. The same metabolomic assay platform at the laboratory of Icahn School of Medicine at Mount Sinai has been used for multiple molecular epidemiologic studies of environmental and occupational exposures previously conducted at our branch. Therefore, to ensure scientific comparability across exposures, particularly those related to hematological cancers, it is critical that the current metabolomic analyses of occupational pesticide exposures are performed by the same laboratory using the same protocol and technical analytic methods. Given the unique expertise in both laboratory methodologies and bioinformatic approaches to analyzing the data, the Icahn School of Medicine at Mount Sinai was identified as the only known source capable of fulfilling the requirements of this project.� This notice is not a request for competitive quotation. However, if any interested party, especially small business believes it can meet the above requirement, it may submit a capability statement for the Government to consider. The response and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement.� Responses must be received in the contracting office by 12:00 PM ET, on July 22, 2021.� All responses and questions must be via email to Miguel Diaz, Contracting Officer at miguel.diaz@nih.gov.� A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement.� In order to receive an award, contractors must be registered and have valid certification through SAM.GOV and have Representations and Certifications filled out. Reference: 75N91021Q00151 on all correspondence.
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-
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- Record
- SN06057631-F 20210714/210712230115 (samdaily.us)
- Source
-
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