SOURCES SOUGHT
Q -- Investigating perfluorooctanoic acid exposure and mutational signatures in clear cell renal cell carcinoma
- Notice Date
- 7/12/2021 9:37:20 AM
- Notice Type
- Sources Sought
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- NIH NCI ROCKVILLE MD 20852 USA
- ZIP Code
- 20852
- Solicitation Number
- 75N91021Q00153
- Response Due
- 7/22/2021 9:00:00 AM
- Archive Date
- 08/06/2021
- Point of Contact
- Miguel Diaz, Phone: 2402765439
- E-Mail Address
-
miguel.diaz@nih.gov
(miguel.diaz@nih.gov)
- Description
- DESCRIPTION This Small Business Sources Sought Notice (SBSS) is for information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the National Cancer Institute (NCI). The purpose of this Small Business Sources Sought Notice is to identify qualified small business concerns, including 8(a), HUBZone or Service-Disabled Veteran-owned business concerns, that are interested in and capable of performing the work described herein. The NCI does not intend to award a contract based on responses received nor otherwise pay for the preparation of any information submitted. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This requirement is assigned North American Industry Classification System (NAICS) code 541990 with a size standard of $15 million is being considered. NCI may issue a request for quotation (RFQ) as a result of this Small Business Sources Sought Notice. THERE IS NO SOLICITATION AVAILABLE AT THIS TIME. However, should such a requirement materialize, no basis for claims against NCI shall arise as a result of a response to this Small Business Sources Sought Notice or the NCI�s use of such information as either part of our evaluation process or in developing specifications for any subsequent requirement. BACKGROUND Per- and polyfluoroalkyl substances (PFAS) are chemical pollutants that have emerged as an important environmental health priority. The epidemiologic evidence to date is suggestive of an association between exposure to the PFAS perfluorooctanoic acid (PFOA) and renal cance risk. However, The potential mechanism of action underlying an association between PFOA and kidney cancer is not known; in particular, there is an absence of in vivo human mechanistic evidence. To obtain insight into potential molecular PFOA-related mechanisms underlying renal cancer development, we propose to measure concentrations of PFOA and eight other PFAS in plasma samples collected pre-treatment from 1,085 renal cancer cases with tumor and normal tissue undergoing whole genome sequencing as part of the Mutographs of Cancer project (and plasma from 245 healthy controls). OBJECTIVE The primary objective of this project is to investigate whether plasma concentrations of PFOA and other PFAS are associated with rates of mutation signatures and other somatic features among clear cell renal cancer tumors. A secondary objective of this project is to conduct case-control analyses relating plasma concentrations of PFOA and other PFAS and renal cancer risk. SCOPE To perform this study, the Contractor will receive a shipment of plasma samples (1,330 samples; 200ul serum per sample), measure the plasma PFAS concentrations using high-performance liquid chromatography (analyte separation) and tandem mass spectrometry (detection and quantification) or comparable methods and send a dataset containing the measurements to NCI. CONTRACT REQUIREMENTS/ AND PERSONNEL QUALIFICATIONS The Contractor must have experience conducting PFAS assays using a serum volume of 200ul or less and be able to provide data supporting good assay reproducibility using this sample volume. The Contractor must also be able to complete the contract requirements by February 28, 2022. � The Contractor shall perform the following tasks: Notify NCI by email of receipt of the shipment of the study samples (1,330 samples; 200ul serum per sample), check the samples against the enclosed manifest and log the samples into the Contractor�s laboratory inventory system. Using the 200ul aliquots, measure plasma concentrations of the selected PFAS [perfluoro-hexanesulfonic acid (PFHxA), pefluorononanoic acid (PFNA), perfluorooctanesulfonic acid (PFOS), sum of perfluoromethylheptane sulfonic acid isomers (Sm-PFOS), linear perfluorooctanoic acid (n-PFOA), sum of branched PFOA isomers (Sb-PFOA), N-methyl-perfluorooctane sulfonamido acetic acid (MeFOSAA), 2-N-ethyl-perfluorooctane sulfonamido acetic acid (EtFOSAA), Perfluoroundecanoic acid (PFUnDA), Perfluorodecanoic acid (PFDA).]. The assays shall be performed using solid phase extraction liquid chromatography and tandem mass spectrometry or comparable methods. Send a dataset (Excel or tab-delimited text file format) containing the PFAS measurements to NCI along with documentation describing the variable labels and formats. TYPE OF ORDER This will be issued as a firm fixed price purchase order. PERIOD OF PERFORMANCE The period of performance is from date of award to February 28, 2022. PLACE OF PERFORMANCE All work shall be performed at the Contractor�s facility. REPORT(S)/DELIVERABLES AND DELIVERY SCHEDULE All deliverables shall be sent electronically (unless approved by the COR) per the following deliverable schedule: DELIVERABLES #1 (Task 4.1) -� Notify NCI by email of successful receipt of study samples.��Upon receipt of sample shipment #2 (Tasks 4.3) Send a dataset (Excel or tab-delimited text file format) containing the PFAS measurements to NCI along with documentation describing the variable labels and formats.��30 days prior to end of period of performance PAYMENT Payment shall be made in full upon delivery and acceptance by the Government. Payment authorization requires submission and approval of invoices to the COR and NIH OFM, in accordance with the attached payment provisions listed below: The following clause is applicable to all Purchase Orders, Task or Delivery Orders, and Blanket Purchase Agreement (BPA) Calls:� Prompt Payment (Jan 2017) FAR 52.232-25.� Highlights of this clause and NIH implementation requirements follow: Invoice Requirements An invoice is the Contractor's bill or written request for payment under the contract for supplies delivered or services performed.� A proper invoice is an ""Original"" which must include the items listed in subdivisions 1 through 12, below, in addition to the requirements of FAR 32.9.� If the invoice does not comply with these requirements, the Contractor will be notified of the defect within 7 days after the date the designated billing office received the invoice (3 days for meat, meat food products, or fish, and 5 days for perishable agricultural commodities, dairy products, edible fats or oils) with a statement of the reasons why it is not a proper invoice.� (See exceptions under II., below.)� Untimely notification will be taken into account in the computation of any interest penalty owed the Contractor. Vendor/Contractor:� Name, Address, Point of Contact for the invoice (Name, title, telephone number, e-mail and mailing address of point of contact). Remit-to address (Name and complete mailing address to send payment). Remittance name must match exactly with name on original order/contract.� If the Remittance name differs from the Legal Business Name, then both names must appear on the invoice. Invoice date. Unique invoice #s for all invoices per vendor regardless of site. NBS document number formats must be included for awards created in the NBS:� Contract Number; Purchase Order Number; Task or Delivery Order Number and Source Award Number (e.g., Indefinite Delivery Contract number; General Services Administration number); or, BPA Call Number and BPA Parent Award Number. Data Universal Numbering System (DUNS) or DUNS + 4 as registered in the Central Contractor Registration (CCR). Federal Taxpayer Identification Number (TIN).� In those exceptional cases where a contractor does not have a DUNS number or TIN, a Vendor Identification Number (VIN) must be referenced on the invoice.� The VIN is the number that appears after the contractor�s name on the face page of the award document. Identify that payment is to be made using a three-way match. Description of supplies/services that match the description on the award, by line billed.* Freight or delivery charge must be billed as shown on the award.� If it is included in the item price do not bill it separately.� If identified in the award as a separate line item, it must be billed separately. Quantity, Unit of Measure, Unit Price, Extended Price of supplies delivered or services performed, as applicable, and that match the line items specified in the award.* NOTE:� If your invoice must differ from the line items on the award, please contact the Contracting Officer before submitting the invoice.� A modification to the order or contract may be needed before the invoice can be submitted and paid. Shipping costs will be reimbursed only if authorized by the Contract/Purchase Order.� If authorized, shipping costs must be itemized.� Where shipping costs exceed $100, the invoice must be supported by a bill of lading or a paid carrier's receipt. The�Contractor shall submit invoice to the National Institutes of Health (NIH)/Office of Financial Management (OFM) via email at invoicing@nih.gov with a copy to the approving official, as directed below. The�Contractor must follow step-by-step instructions as stated in the NIH/OFM Electronic Invoicing Instructions for NIH Contractors/Vendors, which is included as an attachment on the website at https://oamp.od.nih.gov/DGS/DGS-workform-information/attachment-files. The invoice shall be transmitted as an attachment via email to the address listed above in one of the following formats: Word, or Adobe Portable Document Format (PDF). The Contractor must submit only one invoice per email. Do not submit supporting documentation (e.g., receipts, time sheets, vendor invoices, etc.) with your invoice unless specified elsewhere in the contract or requested by the Contracting Officer. The Contractor shall submit a copy of the electronic invoice to the following Technical Point of Contact (TPOC): Technical Point of Contact (TPOC) Name- ___________________Email Address- For inquiries regarding the status of invoices, contact OFM Customer Service via email at ofm_customer_service@incontactemail.com or via phone at 301-496-6088. To send your inquiries via other available communication methods refer to the OFM Customer Service website at https://ofm.od.nih.gov/Pages/Customer-Service.aspx. Note: The OFM Customer Service is open Eastern Standard Time Monday � Friday from 8:30 a.m. to 5:00 p.m. and is closed between 12:00 p.m. to 1:00 p.m. Invoice Payment Except as indicated in paragraph B., below, the due date for making invoice payments by the designated payment office shall be the later of the following two events: The 30th day after the designated billing office has received a proper invoice. The 30th day after Government acceptance of supplies delivered or services performed. � The due date for making invoice payments for meat and meat food products, perishable agricultural commodities, dairy products, and edible fats or oils, shall be in accordance with the Prompt Payment Act, as amended. Interest Penalties An interest penalty shall be paid automatically, if payment is not made by the due date and the conditions listed below are met, if applicable. A proper invoice was received by the designated billing office. A receiving report or other Government documentation authorizing payment was processed and there was no disagreement over quantity, quality, or contractor compliance with a term or condition. � In the case of a final invoice for any balance of funds due the contractor for ����������� supplies delivered or services performed, the amount was not subject to further ��������� settlement actions between the Government and the Contractor. Determination of interest and penalties due will be made in accordance with the provisions of the Prompt Payment Act, as amended, the Contract Disputes Act, and regulations issued by the Office of Management and Budget. PROVIDING ACCELERATED PAYMENT TO SMALL BUSINESS SUBCONTRACTORS, FAR 52.232-40 (December 2013) Upon receipt�of accelerated payments from the Government,�the�Contractor shall make accelerated payments to its small business subcontractors under this contract, to the maximum extent practicable and prior to when�such payment is otherwise�required under the applicable contract or subcontract, after receipt of a proper invoice and all other required documentation from the small business subcontractor.� The�acceleration of payments under this clause does not provide any new rights under the prompt Payment Act. Include the substance of this clause, include this paragraph c, in all subcontracts with small business concerns, including subcontracts with small business�concerns for the acquisition of commercial items.� SUBMISSION INFORMATION Capability statements shall be submitted via email to Contracting Officer, Miguel Diaz, at migurl.diaz@nih.gov no later than 12:00 P.M. EST on July 22, 2021 (07/22/2021). All information furnished must be in writing and must contain enough detail to allow the NCI to determine if it can meet the unique specifications described herein.�Please reference number 75N91021Q00153 on all correspondence. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s capability. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, an RFQ may be published. However, responses to this notice will not be considered adequate responses to a solicitation(s).
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