SOURCES SOUGHT
Q -- Single-nucleus RNA-sequencing from choroid plexus of aged APP/PSEN1 mutant mice
- Notice Date
- 8/5/2021 7:40:58 AM
- Notice Type
- Sources Sought
- NAICS
- 621511
— Medical Laboratories
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-75N95021Q00345
- Response Due
- 8/19/2021 7:00:00 AM
- Archive Date
- 09/03/2021
- Point of Contact
- Eric McKay, Karen Mahon
- E-Mail Address
-
eric.mckay@nih.gov, karen.mahon@nih.gov
(eric.mckay@nih.gov, karen.mahon@nih.gov)
- Description
- This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background:� This acquisition will help satisfy one of the aims of a bigger project trying to understand a novel aspect of the Alzheimer�s disease pathology. By analyzing the transcriptional changes with single-cell resolution, we will be able to differentiate responses of the many groups of cells that comprise the tissue, while at the same time comparing the number of cells in each group. Noticeably, comparison between the two sexes will give us invaluable insight on the sexual differences observed in Alzheimer�s disease. Purpose and Objectives: This acquisition is a service to isolate nuclei from frozen tissue, library preparation, single-nucleus RNA-sequencing, and data analysis. This is a critical step in a project aiming to understand the changes associated with Alzheimer�s disease. With this project, and with this acquisition, we will be able to identify differences in the pathology between the two sexes, with the potential to identify new biomarkers. Project requirements: Quality control of isolated nuclei shall be performed by the contractor. Different optimization protocols were already tested. A minimum number of 5000 nuclei shall be isolated for each sample. Library preparation, RNA sequencing, and data analysis shall all be performed by the contractor. Raw data and summarized reports will be available to us by the end of this project. Anticipated period of performance: 120 days after award Capability statement /information sought. Respondents must provide, as part of their responses, a capability statement that includes information regarding respondents�: (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information. The respondent must also provide their� DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in an outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer.� Facsimile responses are NOT accepted. The response must be submitted to Karen Mahon, Contracting Officer, at Karen.Mahon@nih.gov and Eric McKay, Contracting Officer at Eric.McKay@nih.gov. The response must be received on or before August 19, 2021 at 10:00 am, Eastern Time. �Disclaimer and Important Notes:� This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).�
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/aa6db5dccebf464b8c4ab8c4f7d443f2/view)
- Record
- SN06087409-F 20210807/210805230131 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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