SOLICITATION NOTICE
Q -- Single-nucleus RNA-sequencing from choroid plexus of aged APP/PSEN1 mutant mice
- Notice Date
- 9/2/2021 8:48:02 AM
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 621511
— Medical Laboratories
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIA ROCKVILLE MD 20852 USA
- ZIP Code
- 20852
- Solicitation Number
- HHS-NIH-NIDA-RFP-75N95021Q00345
- Response Due
- 9/3/2021 1:00:00 PM
- Archive Date
- 09/18/2021
- Point of Contact
- ERIC MCKAY, Phone: 3014802406
- E-Mail Address
-
eric.mckay@nih.gov
(eric.mckay@nih.gov)
- Description
- �(i)�This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. (ii)�The solicitation number is HHS-NIH-NIDA-RFP-75N95021Q00345 and the solicitation is issued as a request for proposal (RFP). This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13�Simplified Acquisition Procedures; FAR Subpart 13.5�Simplified Procedures for Certain Commercial Items; and FAR Part 12�Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. (iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) Number 2021-06, with an effective date of July 12, 2021. (iv) The associated NAICS code is 621511 and the small business size standard is $35 million. This requirement is full and open with no set-aside restrictions. (v)�This requirement is for a service to isolate nuclei from frozen tissue, library preparation, single-nucleus RNA-sequencing, and data analysis. This is a critical step in a project aiming to understand the changes associated with Alzheimer�s disease. With this project, and with this acquisition, we will be able to identify differences in the pathology between the two sexes, with the potential to identify new biomarkers. (vi)�Quality control of isolated nuclei shall be performed by the contractor. Different optimization protocols were already tested. A minimum number of 5000 nuclei shall be isolated for each sample. Library preparation, RNA sequencing, and data analysis shall all be performed by the contractor. Data analysis should include but is not limited to Demultiplexing, Quality control, Sequence Alignment, Quantifying expression levels of each cell, Clustering of single cells to identify subpopulations, Aggregate analysis by pooling samples together for different genes, and Expression analysis under the given sub-population. Raw data and summarized reports will be available to us by the end of this project. See �Attachment 1 � Statement of Work� for full requirements. (vii)�The Government anticipates award of a firm fixed-price purchase order for this acquisition, and the anticipated period of performance is 120 days after receipt of the order (viii)�The provision at FAR 52.252-1, Solicitation Provisions Incorporated by Reference (Feb 1998), applies to this acquisition. This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at these addresses:� https://www.acquisition.gov/browse/index/far ��https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html �� (End of provision) The following provisions apply to this acquisition and are incorporated by reference: FAR 52.204-7, System for Award Management (Oct 2018) FAR 52.204-16, Commercial and Government Entity Code Reporting (Aug 2020) FAR 52.212-1, Instructions to Offerors-Commercial Items (Jun 2020) FAR 52.212-3, Offeror Representations and Certifications-Commercial Items (Aug 2020) HHSAR 352.239-73, Electronic and Information Technology Accessibility Notice (December 18, 2015) �The clause at FAR 52.252-2, Clauses Incorporated by Reference (Feb 1998), applies to this acquisition. This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at these addresses: https://www.acquisition.gov/browse/index/far ����https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html � (End of clause) The following clauses apply to this acquisition and are incorporated by reference: FAR 52.204-13, System for Award Management Maintenance (Oct 2018) FAR 52.204-18, Commercial and Government Entity Code Maintenance (Aug 2020) FAR 52.212-4, Contract Terms and Conditions--Commercial Items (Oct 2018). Addendum to this FAR clause applies to this acquisition and is attached. HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (December 18, 2015) HHSAR 352.239-74, Electronic and Information Technology Accessibility (December 2015) The following provisions and clauses apply to this acquisition and are attached in full text. Offerors MUST complete the provisions at 52.204-24 and 52.204-26 and submit completed copies as separate documents with their quote. FAR 52.204-24 Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (OCT 2020) FAR 52.204-26 Covered Telecommunications Equipment or Services-Representation (OCT 2020) FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders--Commercial Items (July 2021) NIH Invoice and Payment Provisions (2/2014) (ix)�The provision at FAR clause 52.212-2, Evaluation � Commercial Items, applies to this acquisition.� (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate offers: (i)technical capability (ii) price (iii) past performance [see FAR 13.106-2(b)(3)]. Technical capability and past performance, combined, are significantly more important than price. (b) A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer�s specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award. (x)�The Offerors to include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications-Commercial Items, with its offer. (xi)�The clause at FAR 52.212-4, Contract Terms and Conditions-Commercial Items, applies to this acquisition. Addendum to this FAR clause applies to this acquisition and is attached. (xii)�The clause at FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items, applies to this acquisition and is attached in full text. (xiii) There are no additional contract requirement(s) or terms and conditions applicable to this acquisition. (xiv)�The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. (xv)�Responses to this solicitation must include clear and convincing evidence of the offeror�s capability of fulfilling the requirement as it relates to the technical evaluation criteria. The price proposal must include a description of Nuclei Isolation from tissue, �Single-nuclei RNA library using 10x Genomics platform, Library QC and sequencing, Data Analysis, the unit price per service, breakdown and rationale for other direct costs or materials, and the total amount. The Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All offers must be received by 4:00 p.m., Eastern Daylight Time, on September 3, 2021 and reference Solicitation Number HHS-NIH-NIDA-RFP-75N95021Q00345. Responses must be submitted electronically to Eric McKay at eric.mckay@nih.gov. Fax responses will not be accepted. (xvi)�The name and telephone number of the individual to contact for information regarding the solicitation: Eric McKay Contracting Officer �Phone: 401-480-2406 �E-Mail:eric.mckay@nih.gov
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/96a6da01ac7240109b68a0cddbf8627a/view)
- Place of Performance
- Address: Baltimore, MD 21224, USA
- Zip Code: 21224
- Country: USA
- Zip Code: 21224
- Record
- SN06120652-F 20210904/210902230129 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's SAM Daily Index Page |