SOURCES SOUGHT
66 -- LSM 980 with Airyscan and 34 channel spectral detector, live-cell incubation, motorized stage
- Notice Date
- 12/2/2021 6:22:44 PM
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA(AG)-SBSS-75N95022Q00040
- Response Due
- 12/16/2021 11:00:00 AM
- Archive Date
- 12/31/2021
- Point of Contact
- Fred Ettehadieh
- E-Mail Address
-
Fred.Ettehadieh@nih.gov
(Fred.Ettehadieh@nih.gov)
- Description
- This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. �An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background and Objectives: � The National Institute on Aging, the iPSC Neurodegenerative Disease Initiative (iNDI) plans to measure how neurodegeneration-related mutations alter protein networks of disease-relevant iPSC-derived cells. The most sensitive and scalable method to measure these changes is through a high-resolution confocal microscope. Recent advances in optics technologies, have enabled super resolution quantification of thousands of proteins, including low-abundant proteins, in live cells. Project Requirements: Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed. Specifications: At the minimum, the Government�s salient characteristics are:� Must provide observer 7 with Definite Focus 3 with Automatic Component Recognition for objectives and filter Sets Must provide full environmental control (temperature, CO2, humidity) with thermally isolated objectives for live cell imaging Must provide airyscan 8Y fast mode and 34 channel spectral detector with zoom optic to adapt to illumination for different objective lenses and acquisition modes Must provide 32+2-Channel Quasar Detection Unit, consisting of a calibrated 32 channel multi-element GaAsP detector with typical QE >45% (peak) and two flanking single multi-alkali PMT detectors Must provide a 32 channel Quasar GaAsP detector with micro lenses in front of the individual detector-elements for improved light efficiency. Must provide individual (master) gains for the side PMT�s for the most extreme dyes, plus individual digital gains for the 32 GaAsP channels. Must provide 405, 445, 488, 514, 561, 640, and 730nm laser lines for wavelength range from 380 nm up to 900 nm Must provide fast, parallel acquisition of the entire spectral range as a lambda stack (370 � 760 nm) in one single scan (up to 5 frames per second at 512 x 512). Must provide reproducible high-resolution spectral data acquisition with 2.9 nm or 4.3 nm steps through sequential spectral scanning Must provide automatic component extraction (ACE) of spectra from a lambda stack for a one- click identification of possible reference spectra. Must provide free combination of manually defined reference spectra, automatically extracted reference spectra, and reference spectra stored within the database can be used for performing Linear Unmixing on a lambda stack. Must allow for reference spectra to be stored in a database and later recalled. Must allow for storing spectral information automatically with each unmixed image for traceable and reproducible workflow and unmixing experiments. Must allow for online fingerprinting where image channels are not defined by the traditional detected emission bands but rather by referenced spectra. On-the-fly online unmixing occurs using these referenced spectra to linear unmix the emission bands of overlapping dyes during the image acquisition Must allow for the preservation of 4-8x enhanced Signal to Noise ratio for high speed acquisition in Multiplex mode Must provide system workstation with ZEN Blue 3.4 that includes system Self-Maintenance Tool with a calibration objective for maintaining optimal system performance by automated calibration routines Must provide offline processing workstation Must provide anti-vibration table Must provide shipping, installation and training Anticipated Delivery Date:� Delivery date of 6 months after receipt of purchase order.� Manufacturer warranty for one calendar year beginning date of receipt. Capability Statement: Small business concerns that believe they possess the capabilities to provide the required services should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately.� Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Small businesses must also provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested small businesses are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, reference the solicitation notice number. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in an outline format that addresses each of the elements of the project requirements and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) pages.� The 10-page limit does not include the cover page, executive summary, or references, if requested. All capability statements sent in response to this Small Business Sources Sought Notice must be submitted to Fred Ettehadieh, Contracting Officer, by email at fred.ettehadieh@nih.gov before the closing date and time of this announcement. All responses must be received by the specified due date and time in order to be considered. Facsimile responses are not acceptable. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in the response.� No proprietary, classified, confidential, or sensitive information should be included in your response.� The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate.� Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work.� Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted.� After review of the responses received, pre-solicitation and solicitation notices may be published in Federal Business Opportunities.� However, responses to this notice will not be considered adequate responses to a solicitation.� The solicitation release date is pending.� Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/368ad51dd7c0471b9506ac8ff78dc552/view)
- Place of Performance
- Address: USA
- Country: USA
- Country: USA
- Record
- SN06190275-F 20211204/211202230115 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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