Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF APRIL 27, 2022 SAM #7453
SOURCES SOUGHT

66 -- Custom automated purification fraction collection bed

Notice Date

4/25/2022 2:05:37 PM
 

Notice Type

Sources Sought
 

NAICS

334516 — Analytical Laboratory Instrument Manufacturing
 

Contracting Office

NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
 

ZIP Code

20892
 

Solicitation Number

75N95022Q00212
 

Response Due

5/3/2022 12:00:00 PM
 

Point of Contact

Michelle Cecilia, Phone: 3018277199
 

E-Mail Address

michelle.cecilia@nih.gov
(michelle.cecilia@nih.gov)
 

Description

SOURCES SOUGHT NOTICE� 1.�� �Solicitation Number:�� � 75N95022Q00212 2.�� �Title: �Custom automated purification fraction collection bed 3.�� �Classification Code: �6640 � Instruments and Laboratory Equipment 4.�� �NAICS Code: �334516 � Analytical Laboratory Instrument Manufacturing 5.�� �Size Standard: 1,000 6.�� �Description: � This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. �It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. �Responses will not be considered as proposals or quotes. �No award will be made as a result of this notice. �The Government will NOT be responsible for any costs incurred by the respondents to this notice. �This notice is strictly for research and information purposes only. Background: �NCATS has become a key partner in the Antiviral Program for Pandemics (APP), a multi-agency initiative that includes NIAID and BARDA, to accelerate antiviral development through early discovery and preclinical development of safe and effective oral antivirals. The initial priority for the APP is to develop treatments for SARS-CoV-2 and other coronaviruses, with the program expanding to address other virus families with pandemic potential. NCATS will apply its proficiency in drug discovery and development and its cutting-edge technologies to fill critical needs of the APP, such as (i) target validation, (ii) high-throughput screening (HTS) for drug starting points, (iii) medicinal chemistry for lead optimization, and (iv) preclinical, investigational new drug (IND)-enabling development. APP chemists within DPI are tasked with the discovery and development potential small molecule antiviral treatments for a range of viruses that have pandemic potential. In order to meet the increased demand for sample purification and analysis, the Analytical Chemistry Core (ACC) needs to improve throughput and expand capabilities through procurement of additional instrumentation and equipment, as well as the application of new technologies. Purpose and Objectives: The concepts of throughput and cycle time are of great significance to translational scientists as they endeavor to increase experimental capacity while reducing the therapeutic discovery and development timeline in an effort to rapidly bring more treatments to patients. The development of an efficient method for the transfer of compounds from Medicinal Chemistry to Compound Management (CoMa) enables a faster turnaround between small molecule synthesis and biological assays. The compound workflow consists of 5 stages (synthesis, purification, processing, registration, and storage) each comprised of multiple steps. The ACC is responsible for purification, processing, and registration and has created the SMART Centralized Sample Purification and Processing Platform where internally synthesized compounds progress from sample submission to CoMa in only 5 days (2 days for purification, 2 days for processing, and 1 day for registration). The rationale is that by having the ACC conduct the majority of sample purifications the medicinal chemists are afforded more time to focus on synthesizing compounds and thus establishing a streamlined compound synthesis workflow, which is more efficient and productive. Column chromatography is a single-sample-at-a-time process often making purification a major bottleneck in the medicinal chemistry pipeline. Despite this fixed parameter, advancements can be made with instrumentation, automation, methods development, and systems integration to create the most efficient purification workflow possible. The ACC has designed the FluidCore automated purification system as our solution for the technological problem of sample throughput. The ACC worked with Tecan on the design and development of an innovative and custom sample management and fraction collection platform built around the Tecan Freedom EVO150 liquid handling system. This custom Tecan Freedom EVO150 utilizes a dual arm fraction collection bed capable of accommodating a wide range of sample vessels, which can be arranged in a variety of configurations. The FluidCore system consists of the custom Tecan Freedom EVO150 platform connected with Waters analytical and purification LC instrumentation creating a single platform for automated purification. By developing the FluidCore automated purification system, current manual steps of the workflow will be replaced with automated protocols. The integrated Waters analytical UPLC-MS will be used to analyze pre-purification samples for automated method development. The Waters preparative LCMS will then use this method for purification of the sample where individual fractions are dispensed into containers on the custom Tecan Freedom EVO150 fraction collection bed followed by automated fraction analysis by the analytical UPLC-MS. Performance of all these processes within the same platform in an automated fashion will improve operational efficiency and reduce the cycle time for a compound to go from synthesis to plating in an effort to accelerate the drug discovery process. The custom Tecan Freedom EVO150 liquid handling platform is required as it is the core component of the ACC FluidCore automated purification system. Project requirements: �Custom Tecan EVO 150 Liquid Handling Platform � Brand name or similar� . us10294 - LCMS Purification EWS With the following custom configuration: a. Freedom EVO150 � �i. 10641150 - Freedom EVO 150 Base Unit, includes 1 year warranty; QTY: 1 � �ii. 10643121 - Deck, 150, Stainless Steel; QTY: 1 � �iii. 30097461 - Safety Shield Set, Closed, Freedom EVO 150, Grey; QTY: 1 � �iv. 10619674 - System Liquid Container, 30L; QTY: 2 � �v. 10619820 - Waste Liquid Container, 30L, Freedom EVO; QTY: 2 � �vi. CER - Cutout for waste chute; QTY: 1 b. Arm #1- 8-Channel Liquid Handling Arm � �i. 10642102 - Liquid Handling Arm (LiHa), 8-tip; QTY: 1 � �ii. 30019983 - Tubing, Interconnect, required for each Liquid Channel; QTY: 8 � �iii. 30019982 - Tubing, Pipette, Standard Volume, FEP, 2.5mm x 1.5mm, Length 3.1M; QTY: 8 � �iv. 10619426 - Syringe, 2500?L, XP diluters, flat cap; QTY: 8 � �v. 30029016 - FastWash Dual Pump, Upgrade Kit, Standard Tubing, 2 LiHa System; QTY: 1 � �vi. 10613001 - Wash Station, LiHa, Standard, Freedom EVO; QTY: 1 � �vii. 10643050 - Tip, Standard, Non-adjustable, PTFE Coated, includes Lock Nut; QTY: 4 � �viii. 30019984 - Disposable Tip Cone Assembly, Standard; QTY: 4 c. Arm #2- 8-Channel Liquid Handling Arm � �i. 10642005 - Second Liquid Handling Arm (LiHa), 8-tip; QTY: 1 � �ii. 30019983 - Tubing, Interconnect, required for each Liquid Channel; QTY: 8 � �iii. 30019982 - Tubing, Pipette, Standard Volume, FEP, 2.5mm x 1.5mm, Length 3.1M; QTY: 8 � �iv. 10619426 - Syringe, 2500?L, XP diluters, flat cap; QTY: 8 � �v. 10613001 - Wash Station, LiHa, Standard, Freedom EVO; QTY: 1 � �vi. 10643050 - Tip, Standard, Non-adjustable, PTFE Coated, includes Lock Nut;� QTY: 4 � �vii. 30019984 - Disposable Tip Cone Assembly, Standard; QTY: 4 d. Robotic Gripper Arm � �i. 30013045 - Robotic Manipulator Arm (RoMa), extended z-rail; QTY: 1 � �ii. 30017037 - RoMa Fingers, Standard Length, set of 2; QTY: 1 � �iii. CER - Deck Cut Out; QTY: 1 � �iv. CER - Shelf on deck for tube racks; QTY: 1 e. Diluter, Valve and Tubing for LCMS Loading � �i. CER - Diluter; QTY: 2 � �ii. CER - Valve System; QTY: 2 � �iii. CER - Tubing; QTY: 2 � �iv. CER - Control Board; QTY: 2 f. Vacuum for Tube Evacuation � �i. 30119213 - US Valve Isolation 2-Way; QTY: 2 � �ii. 30045068 - Vacuum Pump, Chemically Resistant, Te-VacS External Vacuum Option; QTY: 2 � �iii. 30098066 - Silencer for KNF Vacuum Pump; QTY: 2 � �iv. 30031385 - Bottle Set, Standard, for Vacuum Filtration, HydroFlex; QTY: 1 � �v. CER - Tubing and Fittings; QTY: 1 g. Robotic Gripper Arm � �i. 30013045 - Robotic Manipulator Arm (RoMa), extended z-rail; QTY: 1 � �ii. 30017037 - RoMa Fingers, Standard Length, set of 2; QTY: 1 � �iii. CER - Deck Cut Out; QTY: 1 � �iv. CER - Shelf on deck for tube racks; QTY: 1 h. Diluter, Valve and Tubing for LCMS Loading � �i. CER - Diluter; QTY: 2 � �ii. CER - Valve System; QTY: 2 � �iii. CER - Tubing; QTY: 2 � �iv. CER - Control Board; QTY: 2 i. Six Way Valve and Dispenser for Flasks � �i. 30079442 - Valve, 6-Way, Large Volume; QTY: 1 � �ii. 30012177 - Tubing, 6-Way Valve; QTY: 1 � �iii. CER - Dispenser system for flasks; QTY: 1 j. Computer and Software � �i. 10615150 - EVOware Standard Software, EVO 100, 150, and 200; QTY: 1 � �ii. 30158027 - Computer, Desktop, Windows 10 Professional; QTY: 1 � �iii. 30123658 - Monitor, Touchscreen, LCD, Planar; QTY: 1 � �iv. 30024944 - Keyboard and Mouse, Wireless; QTY: 1 � �v. CER - Virscidian Driver for HPLC control and analysis; QTY: 1 � �vi. CER - LCMS EVOware Driver; QTY: 1 � �vii. CER - SPT Labtech Receiver Driver; QTY: 1 k. Worktable Carriers � �i. 30097475 - DiTi Carrier , LiHa, 3-Position with Waste Site, includes DiTi Waste Chute and Cover, Silver; QTY: 1 � �ii. 30013061 - Microplate Carrier, 4-Position, Landscape, Low Profile; QTY: 6 � �iii. CER - MTP Tube Racks; QTY: 24 � �iv. CER - Flask locator under x rail; QTY: 1 � �v. CER - Mounting and access for SPT Labtech Receiver rear and left side; QTY: 2 2. 30001582 - Installation & Software Overview a. LW Labwerx In-house setup, testing, acceptance testing, installation 3. 30001572 - Shipping and Handling One (1) each of all products #1-3 listed in salient characteristics Anticipated period of performance: Product must have a 12-month manufacturer�s warranty to begin upon instrument installation. Delivery � Six months ARO. Other important considerations: Cite any other information that is necessary for potential respondents to understand the nature of the potential requirement or proposed acquisition.� In case domestic sources are available and capable of fulfilling the Government�s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25. Capability statement /information sought.� Small business concerns that believe they possess the capabilities to provide the required products should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately. �Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Small businesses must also provide their Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information.� Interested small businesses are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. The respondent must also provide their Unique Entity ID from SAM.gov, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. �A cover page and an executive summary may be included but is not required.� The response is limited to ten (10) page limit. �The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. �Facsimile responses are NOT accepted. The response must be submitted to Michelle Cecilia, Contracting Officer at e-mail address michelle.cecilia@nih.gov and must include the Solicitation Number 75N95022Q00212. The response must be received on or before May 3, 2022, at 3:00 p.m., Eastern Time. �Disclaimer and Important Notes: �This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work.� Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).� �
 

Web Link

SAM.gov Permalink
(https://sam.gov/opp/953810738cef407d9f37d0581bd46035/view)
 

Place of Performance

Address: Bethesda, MD 20892, USA

Zip Code: 20892

Country: USA
 

Record

SN06307366-F 20220427/220425230103 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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