SOURCES SOUGHT
Q -- Predicting cognitive decline across the Alzheimer�s disease spectrum using plasma proteomics
- Notice Date
- 4/28/2022 9:06:12 AM
- Notice Type
- Sources Sought
- NAICS
- 621511
— Medical Laboratories
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- 75N95022Q00217
- Response Due
- 5/13/2022 6:00:00 AM
- Point of Contact
- Jeanette Russell, Phone: (301) 827-5140
- E-Mail Address
-
Jeanette.Russell@nih.gov
(Jeanette.Russell@nih.gov)
- Description
- This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition; and (4) availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background: Alzheimer�s disease (AD) is a neurodegenerative condition characterized by progressive cognitive and functional decline as well as tau-containing neurofibrillary tangles and amyloid beta (A?) deposits. Currently, no effective interventions exist to slow or stop the progression of AD. Several biomarkers have been widely used to capture AD pathology in vivo, including fluid and neuroimaging biomarkers of A? and tau, whereas lesser explored biomarkers such as glial fibrillary acidic protein (GFAP) are rapidly gaining support for their utility in the context of AD. A? and tau have been at the center of AD research for decades, and it is now understood that these two features do not fully explain the emergence and progression of cognitive decline and other clinical symptoms in the context of AD. Thus, an improved understanding of the biological processes that regulate cognitive decline across the AD continuum is warranted. Using plasma specimens from the Baltimore Longitudinal Study of Aging (BLSA), the present study aims to identify a set of plasma proteins associated with cognitive decline in individuals with preclinical/prodromal AD. This approach will use available plasma biomarkers of brain amyloid accumulation (Ab42/40) and tau phosphorylation (p-tau181) to identify a subset of non-demented older adults with preclinical/prodromal AD. Within this participant subgroup, we will identify individual plasma proteins and protein combinations that are associated with future cognitive decline. We will conduct a parallel analysis in non-demented individuals with biomarker evidence of absent or minimal AD pathology, allowing us to contrast the identified protein sets, and use pathway analyses to understand how the biological processes associated with cognitive decline differ based on the presence (or level) of AD pathology. We expect that this analysis will yield a novel set of plasma protein panels that can be used to identify individuals at greatest risk cognitive decline in the coming years. Discovery-based proteomics will also be used examine the proteomic signature of non-AD neurodegenerative and neuroinflammatory conditions (e.g., multiple sclerosis) using banked specimens from existing cohorts. This multi-etiology comparison will further enhance our ability to identify disease-common and disease-specific biomarkers. We will combine the results of the 7,000 assays performed in this analysis with the results previously derived from other samples. Purpose and Objectives: The purpose of this requirement is to utilize a discovery-based proteomics platform in archived plasma samples collected in the Baltimore Longitudinal Study of Aging (BLSA) to identify circulating molecules and molecular pathways that accelerate cognitive decline, particularly in individuals at risk for Alzheimer�s disease (AD). We will combine this data with data previously analyzed with SomaLogic technology. Discovery-based proteomics will also be used to examine the proteomic signature of non-AD neurodegenerative and neuroinflammatory conditions using banked specimens from other existing cohorts. Project requirements: Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work attached to this Sources Sought notice Anticipated period of performance: 6 months after receipt of samples Capability statement /information sought. Small business concerns that believe they possess the capabilities to provide the required services should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately.� Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Small businesses must also provide their Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. Interested small businesses are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. The respondent must also provide their Unique Entity ID from SAM.gov, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit.� The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer.� Facsimile responses are NOT accepted. All responses to this notice must be submitted electronically to the Contract Specialist.� Facsimile responses are NOT accepted. The response must be received on or before Friday, May 13, 2022 at 9:00 am, Eastern Time. �Disclaimer and Important Notes:� This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).�
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/de14a68f519a416f978b0fb33814f732/view)
- Place of Performance
- Address: Baltimore, MD, USA
- Country: USA
- Country: USA
- Record
- SN06311925-F 20220430/220428230108 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's SAM Daily Index Page |