SAMDaily.us | SRCSGT | 66 | Chromium Single-Cell Gene Expression Kits

SAMDAILY.US - ISSUE OF MAY 27, 2022 SAM #7483
SOURCES SOUGHT

66 -- Chromium Single-Cell Gene Expression Kits

Notice Date: 5/25/2022 8:07:26 AM
Notice Type: Sources Sought
NAICS: 334516 — Analytical Laboratory Instrument Manufacturing
Contracting Office: NATIONAL INSTITUTES OF HEALTH NIA ROCKVILLE MD 20852 USA
ZIP Code: 20852
Solicitation Number: HHS-NIH-NIDA-SS-75N95022Q00267
Response Due: 6/7/2022 1:00:00 PM
Point of Contact: ERIC MCKAY, Phone: 3014802406
E-Mail Address: eric.mckay@nih.gov
(eric.mckay@nih.gov)
Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition; and (4) availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality. For equipment/supply requirements, small business responses must include: (1) the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture), as well as (2) the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule). Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.ï¿½ It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.ï¿½ Responses will not be considered as proposals or quotes.ï¿½ No award will be made as a result of this notice.ï¿½ The Government will NOT be responsible for any costs incurred by the respondents to this notice.ï¿½ This notice is strictly for research and information purposes only. Background: The project utilizing these reagents will focus on single nucleus RNA and chromatin accessibility sequencing in the entorhinal cortex during neurologically normal human aging. snRNAseq and snATACseq will be performed simultaneously using the 10xGenomics Multiome kit and tissue samples of entorhinal cortex [susceptible to Alzheimerï¿½s disease pathology] derived from neurologically healthy individuals across the human lifespan.ï¿½ Purpose and Objectives: The purpose of this acquisition is to provide supplies and reagents to the Laboratory of Neurogenetics for neurodegenerative disease research for gene expression analyses. The following items are required: Chromium Next GEM Single Cell Multiome ATAC + Gene Expression Reagent Bundle, 16 rxns ï¿½ Qty(2) Chromium Next GEM Single Cell Multiome ATAC + Gene Expression Reagent Bundle, 4 rxns ï¿½ Qty(1) Chromium Next GEM Chip J Single Cell Kit, 48 rxns - Qty(1) Dual Index Kit TT Set A 96 rxns - Qty(1) Single Index Kit N Set A, 96 rxn - Qty(1) One (1) Year Manufacturer Warranty Shipping and Handling Expression kits must be able to meet these specifications: Delivers paired full-length receptor sequences at the single cell level using universal and unbiased amplification strategies, thus avoiding amplification and detection bias associated with complex multiplex PCR while revealing deeper biological complexity of antigen specificity on a per-cell basis than single-chain methods. Both snRNAseq and snATACseq will be performed simultaneously using the 10xGenomics Multiome kit, therefore it is critical that the product is able to characterize complex cell populations and capture cellular heterogeneity. The incorporation of a unique molecular identifier (UMI) in the template switch oligo enables transcript quantification and further reduces systematic bias by controlling for non-biological SNVs or other variants introduced by PCR and sequencing error. ï¿½ Enables the detection of germline and somatic variation across full-length gene sequences. ï¿½ Identifies both productive and non-productive recombination events. ï¿½ Maps transcription start sites. Anticipated delivery: The anticipated delivery date is 30 days after receipt of completed purchase order. Other important considerations: In case domestic sources are available and capable of fulfilling the Governmentï¿½s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25. Capability statement /information sought. Small business concerns that believe they possess the capabilities to provide the required products should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately.ï¿½ Additionally, the capability statement should include 1) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 2) any other information considered relevant to this program. Small businesses must also provide their Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. Interested small businesses are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. The respondent must also provide their Unique Entity ID from SAM.gov, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2ï¿½ x 11ï¿½ paper size, with 1ï¿½ top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.ï¿½ A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit.ï¿½ The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondentsï¿½ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contracting Officer.ï¿½ Facsimile responses are NOT accepted. The response must be submitted to Eric McKay, Contracting Officer, at eric.mckay@nih.gov. The response must be received on or before June 7, 2022, 4:00 pm, Eastern Time. ï¿½Disclaimer and Important Notes:ï¿½ This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organizationï¿½s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).ï¿½
Web Link: SAM.gov Permalink
(https://sam.gov/opp/44a611a5842844c693049a4670f22986/view)
Place of Performance: Address: Bethesda, MD 20892, USA; Zip Code: 20892; Country: USA
Record: SN06339091-F 20220527/220526100803 (samdaily.us)
Source: SAM.gov Link to This Notice
(may not be valid after Archive Date)

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66 -- Chromium Single-Cell Gene Expression Kits