Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF JUNE 24, 2022 SAM #7511
SOURCES SOUGHT

Q -- High Precision Mass Spectrometry Assays to Track the Temporal Progression of Plasma AD Biomarkers in BLSA PET Participants

Notice Date

6/22/2022 7:07:43 PM
 

Notice Type

Sources Sought
 

NAICS

621511 — Medical Laboratories
 

Contracting Office

NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
 

ZIP Code

20892
 

Solicitation Number

75N95022Q00330
 

Response Due

7/7/2022 7:00:00 AM
 

Point of Contact

Fred Ettehadieh
 

E-Mail Address

Fred.Ettehadieh@nih.gov
(Fred.Ettehadieh@nih.gov)
 

Description

This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background: The National Institute on Aging (NIA) has followed selected Baltimore Longitudinal Study of Aging (BLSA) participants using PET scanning to track the progression of amyloid and tau in the brain.� Measures of plasma biomarkers of AD pathology and neurodegeneration have also recently been performed using Simoa assays to track AB40, AB42, GFAP, NF-Light, and pTau 181 in samples concurrent with PET imaging assessments.� Preliminary results suggest that changes in some biomarkers have already occurred prior to the first PET scan studies.� Further, a recent head to head comparison was published demonstrating the superiority of mass spectrometry versus Simoa assays in predicting brain amyloid measured by PET. Thus, this procurement is to perform high precision mass spectrometry assays of plams biomarkers, prior to and concurrent with PET amyloid and tau assessments. Purpose and Objectives: In a selected subsample of BLSA participants, brain amyloid and tau have been measured to track the temporal progression of AD pathology in relation to neurodegeneration, cognitive decline and impairment.� Since 2005, PET-PiB (Pittsburgh Compound B) has been used to measure brain amyloid in more than 200 participants (~700 visits), and since 2016, 18-F- Flortaucipir (AV-1451) has been used to measure regional distribution of brain tau.� More recently, plasma biomarkers of AD pathology and neurodegeneration from stored BLSA samples have been evaluated for visits concurrent with PET studies.� These include AB40, AB42, GFAP, NF-Light, and pTau 181, measured using Simoa assays.� As noted above, preliminary results of these plasma biomarker studies suggest that some changes in biomarkers may occur before our first PET assessment.� Further, recent studies have demonstrated higher concordance of high precision mass spectrometry compared to Simoa assays with measures of brain amyloid by PET.� Thus, the purpose of the proposed acquision is two-fold: To obtain high precision mass spectrometry measures of plasma biomarkers of amyloid and tau in participants who have received brain PET scans of amyloid and/or tau. To extend these high precision mass spectrometry measures of plasma amyloid and tau in PET participants, by including plasma samples prior to the first PET scan study.� Stored samples are available for these participants as many as 10 to 20 years prior to the first PET amyloid scan.� Project requirements: �Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to provide critical information and unique insights into the temporal progression of plasma biomarkers of AD and neuropathology in relation to PET amyloid, tau, neurodegeneration and cognitive change given the availability of BLSA plasma samples many years prior to PET scanning.� New insights may lead to novel treatments to help prevent or delay AD. Anticipated period of performance: The anticipated period of performance is 12-months. Capability statement /information sought: Small business concerns that believe they possess the capabilities to provide the required services should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately.� Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Small businesses must also provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested small businesses are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, reference the solicitation notice number. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in an outline format that addresses each of the elements of the project requirements and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) pages.� The 10-page limit does not include the cover page, executive summary, or references, if requested. All capability statements sent in response to this Small Business Sources Sought Notice must be submitted to Fred Ettehadieh, Contracting Officer, by email at fred.ettehadieh@nih.gov before the closing date and time of this announcement. All responses must be received by the specified due date and time in order to be considered. Facsimile responses are not acceptable. �Disclaimer and Important Notes:� This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in SAM.gov. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).�
 

Web Link

SAM.gov Permalink
(https://sam.gov/opp/d09dd7d2ed894774a3514e43500d53be/view)
 

Place of Performance

Address: Baltimore, MD, USA

Country: USA
 

Record

SN06365976-F 20220624/220623060618 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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