SOURCES SOUGHT
66 -- Sodium-Proton (23Na/1H) Head Coil
- Notice Date
- 6/30/2022 10:41:35 AM
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- 75N95022Q00340
- Response Due
- 7/15/2022 7:00:00 AM
- Point of Contact
- Renee Dougherty, Phone: 3018278453, Karen Mahon
- E-Mail Address
-
Renee.Dougherty@nih.gov, Karen.Mahon@nih.gov
(Renee.Dougherty@nih.gov, Karen.Mahon@nih.gov)
- Description
- This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement, to determine the method of acquisition, and availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Small businesses are encouraged to respond. For equipment/supply requirements, small business responses must include: (1) the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture), as well as (2) the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule). Background:� Sodium, 23Na, is a naturally abundant nucleus that has been used for MR imaging, including in-vivo clinical studies of brain aging and neurodegeneration. For example, 23Na MR imaging has been shown to be very sensitive to cell death, one of the hallmarks of AD. In the human brain, 23Na is distributed in two compartments: intracellular and extracellular, with a constant concentration gradient maintained between these two compartments via the sodium/potassium pump. Impairment of energy metabolism or cell integrity leads to a disruption of this ionic homeostasis and non-normative intra- and extracellular 23Na concentrations. Indeed, it has been shown that accumulation of 23Na in white matter lesions may be related to increases in 23Na concentration inside either the extra- or intra-cellular (or both) compartments. The former could be related to edema, while the latter may be a consequence of demyelination or gliosis. This high sensitivity and specificity makes 23Na MRI a powerful noninvasive modality to characterize AD pathophysiology. The ongoing availability of modern coil designs, pulse sequences, and image reconstruction methods have led to a significant increase in the application of 23Na MRI in clinical research in recent years. Moreover, the emergence of promising techniques, such as inversion recovery and triple quantum-filtered sodium imaging, enables the selective characterization of different sodium compartments. These outcome measures have the potential to serve as sensitive biomarkers of early impairment in dementia. Thus, incorporating 23Na MRI into NIA�s integrative program of MR-based dementia studies, with clinical and functional correlates, would represent a fundamental expansion of our capabilities and place us at the forefront of this important class of MR studies. In conjunction with NIA�s large multifaceted database of metabolic and functional parameters, researchers anticipate that these studies will provide insight into electrophysiological activity, membrane transport, and other cellular processes in the brain that are notably understudied in normal aging and dementia. Purpose and Objectives: The National Institute on Aging (NIA) requires a sodium-proton (23Na/1H) head coil for sodium brain imaging on the 3T Philips MRI scanner, located at Harbor Hospital in Baltimore. This new coil will allow NIA to detect neuronal death, white matter degradation and edema associated with neurodegenerative diseases such as Alzheimer's disease and vascular dementia. This capability will augment the research program on the etiology of these diseases in humans. Project requirements: Must be capable of transmitting and receiving at the sodium-23 (23Na) frequency of a 3T MRI scanner (33.8 MHz) to acquire a sodium-23 spectrum of a selected brain region. Must be capable of transmitting and receiving at the proton frequency of a 3T MRI scanner (127.7 MHz) to generate proton images for sodium voxel placement and registration. Must fit within the body coil of a Philips 3T MR7700 MRI scanner and fasten securely to the bed of scanner to avoid image artifacts. Must have an inner diameter of at least 26 cm to comfortably fit subject�s head. Must have an active coil length of at least 24 cm to scan the entire brain in the superior-inferior direction. Must have a radio-frequency and DC electrical interface compatible with a Philips 3T MR7700 scanner. Must include probe description files and any other code needed to interface the coil to the scanner�s acquisition software (Gyroscan R5.9 / R11.1 or above). Must incorporate quadrature polarization on proton channel to maximize efficiency for 1H spin excitation and signal reception. Must be capable of exciting and receiving a proton NMR spectrum of a standard sodium phantom with a minimum signal-to-noise ratio of 20:1 in one scan and a maximum line width (full width at half maximum) of 10 Hz in order to produce proton images of sufficient quality to allow reliable sodium voxel placement. Must incorporate quadrature polarization and active decoupling on sodium-23 transmit channel to maximize efficiency for 23Na spin excitation. Must demonstrate ability to excite sodium-23 (23Na) nuclei in a standard sodium phantom with flip angles from 10 degrees to 270 degrees with an error of no more than 5% from the theoretical sinusoidal dependence of integrated signal on flip angle. This is needed to prevent artifacts in spin-echo and stimulated-echo experiments in which 23Na must be excited with precise flip angles. Must incorporate eight sodium-23 receive channels and active decoupling to maximize sensitivity for 23Na signal reception. Must receive a sodium-23 signal from a standard sodium phantom with a minimum signal-to-noise ratio of 20:1 in one scan and a maximum line width (full width at half maximum) of 10 Hz in order to achieve adequate sensitivity in human brain spectroscopy experiments. Anticipated delivery: 9 months after receipt of order Other important considerations: In case domestic sources are available and capable of fulfilling the Government�s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25. Capability statement /information sought. Companies that believe they possess the capabilities to provide the required products should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately.� Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Capability statements must also include the Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. Interested companies are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit.� The 10-page limit does not include the cover page, executive summary, or references, if requested. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer.� Facsimile responses are NOT accepted. The response must be submitted to Renee Dougherty, Contracting Officer, at e-mail address Renee.Dougherty@nih.gov and Karen Mahon, Contracting Officer, at e-mail address Karen.Mahon@nih.gov. � The response must be received on or before July 15, 2022 at 10:00 am, Eastern Time. Disclaimer and Important Notes:� This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/852a8a03f47c48e8b7aa6510e1af2d65/view)
- Place of Performance
- Address: Baltimore, MD, USA
- Country: USA
- Country: USA
- Record
- SN06376109-F 20220702/220630230213 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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