SOLICITATION NOTICE
70 -- Chempacker CRAFT software package
- Notice Date
- 7/15/2022 12:29:05 PM
- Notice Type
- Presolicitation
- NAICS
- 511210
— Software Publishers
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- NOI_75N95022Q00437
- Response Due
- 7/25/2022 1:00:00 PM
- Point of Contact
- Samson Shifaraw, Phone: 3014807153
- E-Mail Address
-
samson.shifaraw@nih.gov
(samson.shifaraw@nih.gov)
- Description
- PRE-SOLICITATION NOTICE OF INTENT NON-COMPETITIVE Notice of Intent:� 75N95022Q00437 INTRODUCTION PURSUANT TO FAR Subpart 5.2�Synopses of Proposed Contract Actions, THIS IS A PRE- SOLICITATION NOTICE OF A PROPOSED CONTRACT ACTION. THIS IS A PRE-SOLICITATION NON-COMPETITIVE NOTICE OF INTENT TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Office of Acquisitions, Contracts Management Branch Blue, NCATS Section on behalf of the National Center for Advancing Translational Sciences intends to negotiate and award a contract for Chempacker CRAFT software package. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS Code 511210-Software Publishers with a Size Standard of $41.5 million. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses of the Federal acquisition Regulation (FAR) in effect through the Federal Acquisition Circular 2022-06, dated May 26, 2022. STATUTORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13�Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source. DESCRIPTION OF REQUIREMENT Project Description NMR spectroscopy is arguably the most powerful analytical tool a chemist has at their disposal for the identification and confirmation of organic molecules. Medicinal chemists at DPI use the NMR instruments daily to collect compound data, as well as conduct more advanced NMR experiments overnight. Constant access to fully functioning NMR instruments is imperative to maintain productivity in the successful pursuit of the DPI mission. Moreover, with chemical and pharmaceutical technologies continuing to evolve, NMR systems and the types of analyses that can be performed have improved and evolved to meet research needs. It is crucial that the medicinal chemists at DPI have access to the latest NMR technologies to streamline and simplify their analytical chemistry workflows. The A Specialized Platform for Innovative Research Exploration (ASPIRE) Program endeavors to develop an autonomous automated synthesis laboratory to address long-standing chemistry challenges, which include a lack of standardization, low reproducibility, and the inability to predict new reaction outcomes. Through the development and use of innovative technologies the ASPIRE program aims to resolve translational bottlenecks with the hope of designing safer and more effective treatments that can reach patients faster. The ACC is working with the ASPIRE team to develop an automated NMR analysis workflow to create a tool to perform analytical analyses at scale. To meet this need, the ACC is developing an automated platform to quantitate compound concentration, purity, and yield accurately and precisely in crude and pure using quantitative NMR spectroscopy (qNMR). qNMR is the use of NMR spectroscopy for identification and quantification of a target compound�s concentration and purity. While qNMR has been widely used in academia and industry, doing so in an automated workflow presents several challenges that we will need to overcome. This includes optimizing the analysis workflow, parameters, and method to be used for accurate and precise quantitation of NMR spectra. Also, we need to be able to create a simplified report summarizing the data analytics in the form of concentration, purity, and/or yield. We intend to utilize the Complete Reduction to Amplitude-Frequency Table (CRAFT) software to accomplish these goals and create the automated qNMR platform. CRAFT is a post-acquisition data reduction algorithm, which converts acquired FIDs into their component NMR signals in the form of a table containing chemical shift (frequency), amplitude, and linewidth data. Unlike other integration or quantification techniques, CRAFT is applied on the time-domain signal. By doing this, one avoids quantitation errors caused by common manual steps such as phase correction and baseline correction and ubiquitous requirements such as baseline-signal resolution. Additionally, database storage of NMR experimental data in a standardized machine-readable format is necessary for automated analysis processes. As such, we require the purchase of the Chempacker CRAFT software package to allow the establishment of a qNMR analysis workflow and enable its utilization within the automated chemistry platform. General Requirements Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified, personnel, material, equipment, and facilities not otherwise provided by the Government as needed to perform the Specific Requirements below: Purchase Description See Attached Period of Performance The period of performance is estimated to be from September 1, 2022 � August 31, 2023. CLOSING STATEMENT This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. The respondents must submit clear and convincing evidence that their product is equivalent or superior to the product specified in this notice. The response shall include: the unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered to determine the method of acquisition. The response must also indicate the country of manufacturer of components and country of assembly (not necessary for IT purchases). A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non- competitive basis or to conduct a competitive procurement. All responses must be received by July 25, 2022 at 4:00 PM Eastern Time and must reference number 75N95022Q00437. Responses must be submitted electronically to Samson Shifaraw, Contract Specialist, at samson.shifaraw@nih.gov, and must reference the solicitation number 75N95022Q00437, on your electronic request. FAX requests are not accepted. All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/558d876cc73f47acbf0cb39ab60ba891/view)
- Place of Performance
- Address: USA
- Country: USA
- Country: USA
- Record
- SN06391084-F 20220717/220715230122 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's SAM Daily Index Page |