SOURCES SOUGHT
66 -- High Pressure Homogenizer
- Notice Date
- 7/15/2022 8:55:39 AM
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- NIMH-22-010133
- Response Due
- 7/21/2022 12:00:00 PM
- Archive Date
- 07/22/2022
- Point of Contact
- Kristina Jenkins
- E-Mail Address
-
kristina.jenkins@nih.gov
(kristina.jenkins@nih.gov)
- Description
- This is a Sources Sought notice. This is�NOT�a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified businesses technically capable of meeting the Government requirement, to determine the method of acquisition, and availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will�NOT�be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Small businesses are encouraged to respond. For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule). Statement of Need and Purpose: The National Institute of Mental Health (NIMH) a need for a High-Pressure Homogenize to study the cell biology of oligodendrocytes. Background: In the central nervous system, oligodendrocytes are cells responsible for producing myelin, the insulation around electrically active axons of neurons. Myelin facilitates fast electrical conductance in an analogous way as rubber insulation around electrical wiring. Proper development and maintenance of oligodendrocytes has important implications on demyelinating disease, including multiple sclerosis, a disease in which immune cells attack and destroy myelin, and leukodystrophies, childhood diseases in which myelin fails to form properly leading to progressive disability. In addition, recent studies also support a role for oligodendrocytes in psychiatric disease and in memory, including in Alzheimer�s disease. NIMH�s lab focuses on understanding the cell biology and building blocks of the oligodendrocyte, and how they contribute to normal brain function and disease. The oligodendrocyte is a cell that is shaped like a tree, with many branches that terminate to form myelin sheaths, which wrap concentrically around the axon in many layers, much like a long paper towel roll or a bolt of fabric. Our questions primarily underly the structure of these branches � microtubules that form the roads of these cells � and the cargos that travel along them, including organelles and mRNA genetic messages. NIMH has recently discovered that protein aggregation in oligodendrocytes may underlie the cellular etiology of the neurological disease MSA. We plan to use this machine to purify the aggregating protein in this disease so that we study its modifications and aggregating properties. Generic Name of Product: High-Pressure Homogenize Purchase Description: High-Pressure Homogenize, Stainless Steel Coiling Coil Salient characteristics Electrical motor driven pump. Voltage 120VAC Pressure adjustable from 500-30000psi Dynamic homogenizing valve with pneumatic control. Flow rate at 3 liters/hour independent of pressure Minimum sample volume at 10ml. All materials within the wetted parts path must withstand prolonged exposure to high pressure steam for the purposes of sterilization (SIP). Wetted parts are autoclavable. Stainless steel cooling coil Quantity:� 1 of each Delivery Date: 4-6 weeks upon receipt of award. Special Instructions: If you or your firm/business has an interest and possess the required expertise we invite you to submit a corporate capability statement to assist the Government in determining in accordance with Federal Acquisition Regulation (FAR) 19.502-2(b) whether or not this procurement will be set-aside for any of the programs described above. The intended procurement will be classified under North American Industrial Classification (NAICS) code�334516�size standard of 1,000 employees.�All respondents are requested to identify their firm's size and type of business.���� Interested firms responding to this�Small Business�Sources Sought Notice�should adhere to the following: Provide a capability statement demonstrating relevant experience, skills and ability to fulfill the Government's requirements for the above.�The capability statement should contain sufficient detail for the Government to make an informed decision regarding your capabilities and at a minimum address the below: Respondents� opinions about the difficulty and/or feasibility of the potential requirement or proposed acquisition. Information regarding respondents�: (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information. Respondents��Unique Entity Identifier (UEI), cage code, organization name and address. Respondents' Socio-economic Status (e.g., HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses). Business size (e.g., small or large) pursuant to the applicable NAICS code. GSA or other Government Contract Number. Clear and convincing documentation of your capability and ability to provide the services. Examples of prior completed contracts and other related information. Any other information that may be helpful in developing or finalizing the requirement. The capability statement should not exceed 15 pages using a font size 10 or larger and shall include: respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses; and the name, address, telephone number, and e-mail address of the Contract Specialist or Contracting Officer to whom the information should be sent. �All capability statements sent in response to this Small Business Sources Sought notice must be submitted electronically (via email) to the�Kristina.Jenkins@nih.gov� in MS Word or Adobe Portable Document Format (PDF)�by the closing date and time of this announcement.�Facsimile responses will not be accepted, and all responses must reference the Notice ID. �Disclaimer and Important Notes.�This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published on SAM.gov�Contract�Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality.�No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).�
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/1ed66ce1c86c4e509f705f94c172548a/view)
- Record
- SN06391302-F 20220717/220715230123 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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