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SAMDAILY.US - ISSUE OF AUGUST 04, 2022 SAM #7552
SPECIAL NOTICE

68 -- Special Notice of Intent to Sole-Source: Radical OX071 for preclinical Electron Paramagnetic Resonance Imaging

Notice Date

8/2/2022 12:44:01 PM
 

Notice Type

Special Notice
 

NAICS

325199 — All Other Basic Organic Chemical Manufacturing
 

Contracting Office

NIH NCI ROCKVILLE MD 20852 USA
 

ZIP Code

20852
 

Solicitation Number

NOI75N91022Q00143
 

Response Due

8/9/2022 1:00:00 PM
 

Point of Contact

Renee Jones-Chuang
 

E-Mail Address

renee.jones-chuang@nih.gov
(renee.jones-chuang@nih.gov)
 

Description

DESCRIPTION OF NOTICE The National Cancer Institute intends to issue a purchase order for Oxo71 EPR imaging agent on a noncompetitive, sole-source basis to General Electric Company (DBA ""GE Healthcare""). Based on market research, this agent is patented by a wholly-owned subsidiary of GE Healthcare and not available for resale from other entities. Thus, GE Healthcare is the only source capable of meeting this requirement. This acquisition will be processed under FAR 13.501(a) and FAR 13.106-1(b)(1) using simplified acquisition procedures. Thus, this acquisition is exempt from the requirements of FAR part 6. This notice is not a request for a competitive quotation; however, if any interested party - especially any small business interest - believes it can fulfill this requirement, it may submit a capability statement or similar information for the Government to consider. The response must be furnished to the NCI in writing and contain material sufficient in detail to allow NCI to determine if the submitter can fulfill the requirement. PROJECT BACKGROUND During the last 30 years, tetrathiatriarylmethyl (TAM) radicals have been widely used as spin probes for oximetry in electron paramagnetic resonance (EPR) spectroscopy and EPR tomography because of the narrow EPR linewidth and high stability in living systems. The Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), requires an EPR-active contrast agent for use in a pre-clinical EPR imaging instrument that is designed, built, and operated in the Radiation Biology Branch. The EPR imager is used to make spatially-resolved measurements of tissue oxygen concentration in the tissues of live animals, using paramagnetic trityl probes Oxo63 and Oxo71 as contrast agents. EPR imaging (EPRI) can be used to quantitatively determine tissue oxygentation because both the spin-lattice relaxation time (TI = 1/R1_ and spin-spin relaxation time (T2 = 1/R2) of paramagnetic electrons are shortened in the presence of oxygen. NCI has identified that Oxo71, a deuterated form of Oxo63, provides superior oxygen imaging characteristics versus Oxo63. Oxo71 can measure a wider dynamic range of oxygen concentrations in vivo. NCI is seeking to procure 20 grams of Oxo71,�the deuterated analog of the trityl radical Oxo63,�for use as an�EPR imaging agent to fulfill the needs of the NCI when performing metabolic imaging research at NCI facilities in Bethesda, MD. REQUESTED INFORMATION Responses should be submitted to the Contract Specialist, Renee Jones-Chuang, by e-mail at renee.jones-chuang@nih.gov no later than the date and time specified in this notice.� *Please reference 75N91022Q00143 on all correspondence* At a minimum, each response should include the following: Business name and address Unique Entity Identifier (UEI) as registered in the System for Award Management (SAM) Business point-of-contact name, e-mail, and phone-number Business website URL Business type (e.g. small business, 8(a), WOSB, educational institution) Interested respondents may also submit any additional information relevant to the services or products their organization offers that they feel NCI should be made aware of, and any questions or requests for additional information necessary to better understand NCI's needs for this requirement. Please note that NCI may not individually answer questions as part of this specific notice; however, questions may be used to inform future potential procurement actions.
 

Web Link

SAM.gov Permalink
(https://sam.gov/opp/cc344d6371b543b58356e9246dfa1703/view)
 

Place of Performance

Address: Rockville, MD 20850, USA

Zip Code: 20850

Country: USA
 

Record

SN06410367-F 20220804/220802230116 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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