SOLICITATION NOTICE
Q -- Synthesis of Thyclotides (R,R) and (S,S)-trans-Tetrahydrofuran- constrained peptide nucleic acids
- Notice Date
- 8/3/2022 1:10:28 PM
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 54138
—
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NICHD BETHESDA MD 20817 USA
- ZIP Code
- 20817
- Solicitation Number
- NICHD-22-229
- Response Due
- 8/13/2022 8:00:00 AM
- Archive Date
- 08/14/2022
- Point of Contact
- GRIFFIN, VERNE L, Phone: 3015947730, HAUN, PATRICIA M, Phone: 13014437786
- E-Mail Address
-
verne.griffin@nih.gov, haunp@mail.nih.gov
(verne.griffin@nih.gov, haunp@mail.nih.gov)
- Description
- This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice.� This announcement constitutes the only solicitation, and a separate written solicitation will not be issued.� This solicitation number isNICHD-22-229 and is issued as a Request for Quotation (RFQ).� The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2022-06.� The North American Industry Classification (NAICS) Code is 54138 and the business size standard is $15.0M.� It is the intent of The National Institutes of Health, National Institute of Child Health and Development (NICHD), in support of the work of the National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK) to award a purchase order, without providing for full and open competition, to Frontage Laboratories, Inc., 700 Pennsylvania Drive, Exton, PA 19341, for Synthesis of Thyclotides (R,R) and (S,S)-trans-Tetrahydrofuran- constrained peptide nucleic acids. Final products must be delivered with requested quantity for each molecule, with purity in excess of 98%. Final products will be analytically tested by NIDDK before final acceptance. Scale of synthesis for the target molecules is not possible in NIDDK labs due to space limitations. Obtaining synthesis service will allow NIDDK lab to pursue advanced experiments without needing to continually repeat established protocols over and over again.�� The Contractor shall: ����������� Starting with the synthetic routes provided by the NIDDK, scale up the synthesis of thyclotide(T), thyclotide (A(Bhoc)), thyclotide (C(Bhoc)), thyclotide (G(Bhoc)), to produce 10 g of each molecule as the methyl ester � the final hydrolysis will not be performed. ����������� Purify each molecule via recrystallization or silica gel chromatography ����������� Synthesis may be performed in batches.� A complete certificate of testing (Analysis) will be provided for each synthetic batch ����������� Provide 10 g of each final compound a glass or plastic canister inside a protected shipping box or package to NIDDK investigator ����������� Perform characterization by NMR and check purity by MS for COT ����������� Provide a Certificate of Analysis (COA) for each molecule synthesized (per batch) The research is to advance the testing of thyclotides and cyclopentane peptide nucleic acids as probes to signal the presence of infection or disease. To properly make the oligomers for this work, the lab must have the correct building blocks that will be made in the proposed contract. Using the procedures provided by the NIDDK chemists, the company must scale up the production of the thyclotides and cyclopentane monomer building blocks and deliver 10 g of each monomer as the methyl ester to the NIDDK lab. Monomers received will be used to make thyclotides probes to target specific nucleic acids sequences associated with infection or disease. Results from each set of tests done are added to the file that will eventually be submitted for FDA approval as a new diagnostic test.� The continuity of the project is enhanced by the use of as few CRO�s as possible and only ones technically qualified to meet the specific needs of the research. The FDA will evaluate the data and expect consistency in how it was compiled and by whom.� In order to preserve all the prior investment in the research work done so far it is critical to select a highly skilled contractor with the expertise to make the proposed molecules. Frontage has developed proprietary chemical expertise to make the target molecules that other companies/contractors will not have access to.� NIDDK has tried other sources and encountered technical difficulties, therefore the recommended contractor is essential to the success off the project. The offeror must include a completed copy of the following provision�s along with their quote:� FAR Clause 52.212-3, Offeror Representations and Certifications � Commercial Items; FAR Clause 52.204-24, Representation Regarding Certain Telecommunication and Video Surveillance Services or Equipment; FAR Clause 52.204-25, Prohibition on Contracting for Certain Telecommunications and Video Surveillance Services or Equipment. The provisions of FAR Clause 52.212-1 Instructions to Offerors � Commercial Items; FAR Clause 52.212-2, Evaluation � Commercial Items: Evaluation Factors (1) technical capability to provide all services/consumables, etc.; (2) price; and (3) past performance. Technical capability and past performance, when combined, are significantly more important than cost/price; FAR Clause 52.212-4, Contract Terms and Conditions � Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders � Commercial Items � Deviation for Simplified Acquisitions applies to this acquisition, apply to this acquisition.� The offeror must include their Unique Entity ID: (UEI), the Taxpayer Identification Number (TIN), and the certification of business size.� The clauses are available in full text at http://www.arnet.gov/far.� Interested vendors capable of providing the Government with the services specified in this synopsis should submit their quotation to the below address.� Quotations will be due ten (10) calendar days from the publication date of this synopsis or August 13, 2022 at 11:00 AM.� The quotation must reference �Solicitation number� NICHD-22-229.� All responsible sources may submit a quotation, which if timely received, shall be considered by the agency.� Quotations must be submitted by email to Verne Griffin at verne.griffin@nih.gov.��� Faxed copies will not be accepted
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/c32ce97d5bbb41218b53dca675e44869/view)
- Record
- SN06412429-F 20220805/220803230110 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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