SOLICITATION NOTICE
A -- VACCINE ADJUVANT DISCOVERY PROGRAM
- Notice Date
- 3/31/2023 7:41:53 AM
- Notice Type
- Solicitation
- NAICS
- 541714
— Research and Development in Biotechnology (except Nanobiotechnology)
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIAID BETHESDA MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- BAA-DAIT-75N93022R00022
- Response Due
- 5/30/2023 12:00:00 PM
- Archive Date
- 06/14/2023
- Point of Contact
- Maribel Miranda, Phone: 2406695139, Tom Bahrami, Phone: 2406695147
- E-Mail Address
-
maribel.miranda@nih.gov, bahramit@niaid.nih.gov
(maribel.miranda@nih.gov, bahramit@niaid.nih.gov)
- Description
- The purpose of this BAA is to renew the NIAID Adjuvant Discovery Program that supports the identification and�characterization of novel, effective and safe vaccine adjuvants. The process of discovery new adjuvants through this�program must include each of the following areas of research: (1) Identification of novel adjuvant candidates using�high throughput (HTS) approaches and validation that lead compounds stimulate human cells; (2) determination of the�mechanism of action of select lead compounds, including the identification of the receptor(s) the adjuvant candidates�work through and/or the cellular signaling pathways they activate; (3) optimization of lead adjuvant candidates through�formulation and medicinal chemistry, guided by structure-activity relationship (SAR) studies; and (4) verification of�the efficacy of lead compounds as vaccine adjuvants in vivo in an animal model. Offerors are encouraged, but not�required, to evaluate lead adjuvant candidates in model systems of vulnerable populations (e.g., newborns, elderly�or immunocompromised individuals). Lead adjuvant candidates identified under a contract project may also be tested�with different vaccine platforms, including nucleic acid-based vaccines. Not only the shortterm efficacy, but also the�durability of the immune response induced by the adjuvanted vaccine must be evaluated.
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/a8ef11561ecd41ba8f8c7210a686c6c7/view)
- Record
- SN06636571-F 20230402/230331230107 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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