SOLICITATION NOTICE
Q -- Acquisition of a DNA Encoded Library (DEL) screening service for the Early Translation Branch (ETB) at NCATS
- Notice Date
- 5/16/2023 6:47:37 AM
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- 75N95023Q00299
- Response Due
- 5/23/2023 1:00:00 PM
- Archive Date
- 06/07/2023
- Point of Contact
- Kaitlyn Landi, Phone: 3018271804, KJ Shaikh, Phone: 3014436677
- E-Mail Address
-
kaitlyn.landi@nih.gov, kj.shaikh@nih.gov
(kaitlyn.landi@nih.gov, kj.shaikh@nih.gov)
- Description
- (i)������� This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. (ii)������� The solicitation number is 75N95023Q00299 and the solicitation is issued as a request for quotations. This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13�Simplified Acquisition Procedures; FAR Subpart 13.5� Simplified Procedures for Certain Commercial Items; and FAR Part 12�Acquisition of Commercial Items and is expected to exceed the simplified acquisition threshold.� (iii)������ The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) Number 2023-02, with effective date March 16, 2023. (iv)������ The associated NAICS code 541990 and the small business size standard is $19.5M.�� This requirement is full and open with no set-aside restrictions. (v)������� This requirement is for the following services: DEL screening service to accelerate the discovery of small molecules of biological interest to the program. The DEL screening will be divided into two parts: the first part will involve the assessment of our protein targets� feasibility for the DEL screening; and upon successful reports, the second part will consist of screening the DNA encoded library with the objective of identifying potential lead compounds that can be followed up with medicinal chemistry studies. Scientists and/or technicians with experience in DEL screening shall run the experiment. PART 1: The contractor will run an initial test for a comprehensive review of DEL screening suitability/feasibility. This experiment will produce a fast-turnaround feasibility assessment of protein reagents provided by NCATS to the contractor for validation prior to screening. With this testing we will also have a process to potentially salvage previously failed targets. For each assessment, the contractor will screen a small portion of the target against their DEL library deck, which features several billion compounds. Within the agreed upon period of performance, the contractor will provide the number of prospective high-quality target engagers and assess the target�s output to provide expert recommendations. This will help us decide which targets to prioritize and de-risk our decision making to ensure the best results. To proceed to PART 2, the feasibility result must show targets provided by NCATS are displaying a high number of highly enriched clusters with structure�activity relationship (SAR). These clusters make it possible to quickly navigate and determine the targets suitability to progress to the DEL screen. PART 2: The contractor will run the DEL screening, based on NCATS� guidance and results from PART 1, which is an experiment to test our purified proteins and cell lysate samples against a DNA Encoded Library comprising of billions of compounds. This screening will provide us with a comprehensive report of hits for medicinal chemistry follow up. For each previously assessed protein/cell lysate, the contractor will screen the target against their DEL deck. Within the agreed upon period of performance, the contractor will provide the number of prospective high-quality target engagers and assess the target�s output to provide expert recommendations. The contractor will: Design and synthesize DNA encoded libraries. Preferably this will contain several billion compounds (7 � 8 billion compounds). Run affinity screening of libraries to ensure enrich for selective binders. Characterize selection output using deep sequencing of DNA tags. Identify enriched library compounds through statistical analysis, which will produce the final report NCATS will receive. (vi)������ Background Information and Objective: ����������� The National Center for Advancing Translational Sciences (NCATS) is part of the National Institutes of Health (NIH), with a mission to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. The Early Translational Branch (ETB) is tasked with identifying and developing novel small molecule leads against a wide spectrum of human disease targets, which it accomplishes by screening thousands of small molecules in collaboration with both intra-and extramural researchers. In pursuit of this goal, discovering small molecules that could serve as starting points for therapeutics is of great interest within NCATS. Medicinal chemistry optimization is often an important exercise in our development of small molecules to test the therapeutic hypothesis in disease models. NCATS uses several strategies and modalities to address many aspects of design approaches to discover novel small molecules. One such strategies is the use of DNA-encoded chemical libraries (DELs) which represent a versatile platform for the discovery of small-molecule ligands to protein targets of biological interest. DELs are collections of molecules, individually coupled to distinctive DNA tags serving as amplifiable identification barcodes. Thanks to advances in DNA-compatible reactions, selection methodologies, next-generation sequencing, and data analysis, DEL technology allows the construction and screening of libraries of unprecedented size; this has led to the discovery of highly potent ligands, some of which have progressed to clinical trials. Part of the process is evaluating the targets� feasibility and suitability for a DEL screen. As part of this initial step, NCATS will send 12 purified proteins or cell lysates for testing. Once the feasibility of these samples is confirmed, NCATS will prioritize and select the six best targets to move forward to the DEL screen.� Successful DEL screens will allow NCATS to find more suitable drug leads for our target disease models we are studying. Government Responsibilities: Part 1: NCATS will prepare and send 12 purified proteins or cell lysates samples to the contractor to conduct the study. The contractor will be required to provide a report that includes test results (feasibility assessment) for the 12 purified proteins or cell lysates provided by NCATS. The report shall include the feasibility results in detail. Part 2: Input, feedback on feasibility test. NCATS will select six purified proteins or cell lysates for the full DEL screen. Deliverables: Part 1: Electronic copy of report as indicated in reporting requirements. Part 2: Electronic copy of report as indicated in reporting requirements. Specific Selection/Technical Evaluation Criteria: Offeror must have a Master Service Agreement (MSA) already in effect with NCATS by the time of quote submission. (vii)����� The Government anticipates award of a firm fixed-price contract for this acquisition, and the anticipated period of performance is 1-2 months ARO for Part 1 and 2-4 months from acceptance of Part 1 for the Part 2 portion. (viii)���� The provision at FAR 52.252-1, Solicitation Provisions Incorporated by Reference (Feb 1998), applies to this acquisition. This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at these addresses:� https://www.acquisition.gov/browse/index/far ��https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html �� (End of provision) The following provisions apply to this acquisition and are incorporated by reference: FAR 52.204-7, System for Award Management (Oct 2018) FAR 52.204-16, Commercial and Government Entity Code Reporting (Aug 2020) FAR 52.212-1, Instructions to Offerors-Commercial Items (Mar 2023) (TAILORED) FAR 52.212-3, Offeror Representations and Certifications-Commercial Items (Dec 2022) FAR 52.222-52, Exemption from Application of the Service Contract Labor Standards to Contracts for Certain Services-Certification (May 2014) HHSAR 352.239-73, Electronic and Information Technology Accessibility Notice (December 18, 2015) The clause at FAR 52.252-2, Clauses Incorporated by Reference (Feb 1998), applies to this acquisition. This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at these addresses: https://www.acquisition.gov/browse/index/far ����https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html � (End of clause) The following clauses apply to this acquisition and are incorporated by reference: FAR 52.204-13, System for Award Management Maintenance (Oct 2018) FAR 52.204-18, Commercial and Government Entity Code Maintenance (Aug 2020) FAR 52.212-4, Contract Terms and Conditions--Commercial Items (Dec 2022). Addendum to this FAR clause applies to this acquisition and is attached. �HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (December 18, 2015) The following provisions and clauses apply to this acquisition and are attached in full text: FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders--Commercial Items (Mar 2023) NIH Invoice and Payment Provisions (Apr 2022) (ix)������ The Government will evaluate quotations or offers in accordance with FAR 13.106-2 and award a purchase order from this solicitation to the responsible offeror whose quote conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate quotes: a. Technical capability of the item offered to meet the Government requirement; b. Price; and c. Past performance. (x)������� The Offerors to include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications-Commercial Items, with its offer. (xi)������ The clause at FAR 52.212-4, Contract Terms and Conditions-Commercial Items, applies to this acquisition. Addendum to this FAR clause applies to this acquisition and is attached. (xii)����� The clause at FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items, applies to this acquisition and is attached in full text. (xiii)���� The following additional contract requirement(s) or terms and conditions as determined by the contracting officer are necessary for this acquisition and consistent with customary commercial practices. Offeror must have a Master Service Agreement (MSA) already in effect with NCATS by the time of quote submission. (xiv)���� The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. (xv)����� Responses to this solicitation must include sufficient information to establish the interested parties� bona-fide capabilities of providing the service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s), product description, and any other information or factors that may be considered in the award decision. Such factors may include: past performance, special features required for effective program performance, trade-in considerations, probable life of the item selected as compared with that of a comparable item, warranty considerations, maintenance availability, and environmental and energy efficiency considerations. Responses to this solicitation must include clear and convincing evidence of the offeror�s capability of fulfilling the requirement as it relates to the technical evaluation criteria. The Unique Entity Identifier (UEI), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All questions must be received by 12:00 p.m. Eastern Standard Time, on Friday 19 May 2023, and reference Solicitation Number 75N95023Q00299. Questions may be submitted electronically to Kaitlyn Landi, Contract Specialist, at Kaitlyn.landi@nih.gov. All quotations must be received by 4:00 p.m., Eastern Standard Time, on Friday 23 May 2023, and reference Solicitation Number 75N95023Q00299. Responses must be submitted electronically to Kaitlyn Landi, Contract Specialist, at Kaitlyn.landi@nih.gov. Fax responses will not be accepted. (xvi)���� The name and telephone number of the individual to contact for information regarding the solicitation: Kaitlyn Landi, Contract Specialist Kaitlyn.landi@nih.gov ATTACHMENTS Statement of Work FAR 52.212-4 Addendum FAR 52.212-5 Contract Terms and Conditions Required to Implement Statutes Executive Orders-Commercial Items (Mar 2023) NIH Invoice and Payment Instructions with IPP (April 2022)
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- Record
- SN06683738-F 20230518/230517212021 (samdaily.us)
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