SOURCES SOUGHT
66 -- Phosphorus-31/Proton (31P/1H) array head coil for 3T MRI scanner
- Notice Date
- 7/10/2023 5:19:31 AM
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- 75N95023Q00466
- Response Due
- 7/21/2023 9:00:00 AM
- Archive Date
- 08/05/2023
- Point of Contact
- Andrea Clay, Phone: 3014802449
- E-Mail Address
-
amcgee@nida.nih.gov
(amcgee@nida.nih.gov)
- Description
- Description:� This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background: � Considerable research interest has been focused on the possible role of bioenergetic derangement in the progress of AD. In particular, it is unclear to what extent bioenergetic deficits in the brain, with its high energy demand, contribute to the development of AD or are consequences of pre-existing AD pathology. Moreover, the connection between these deficits and other pathological processes observed in AD, such as vascular dysfunction, needs elucidation. Fortunately, 31P MRS provides a completely non-invasive means of quantifying high-energy metabolites such as phosphocreatine (PCr), inorganic phosphate (Pi), nucleotide phosphates such as ATP and NAD/NADH and phospholipids such as phosphocholine and phosphoethanolamine. 31P MRS directly detects the 31P nucleus, which is non-radioactive and has a natural abundance of 100% and therefore requires no isotopic labeling or enrichment for observation. Like other magnetic resonance techniques, 31P MRS is spatially-selective, offering localized bioenergetic data for specific regions of the brain, and can be applied longitudinally. In addition to measuring the concentrations of phosphorus-containing metabolites in living tissue, 31P MRS can be used to calculate intracellular pH from the chemical shift difference between the 31P resonances of Pi and a reference peak such as that of PCr. Further, techniques such as saturation transfer and chemical exchange-progressive saturation (CUPS) can be applied to measure the rate of and flux through the creatine kinase reaction, which generates ATP from PCr in response to increased energetic demand. Thus, 31P MRS is an ideal means of probing metabolic changes in the brain that accompany the onset and progression of AD. Purpose and Objectives: The purpose of this acquisition is to procure a phosphorus-proton (31P/1H) array head coil for phosphorus brain imaging on NIA's 3T Philips MRI scanner Description: Contractor will provide the following: 31P / 1H head coil array; part number P-XQS-X08LE-HQ-030 Salient characteristics: Must be capable of transmitting and receiving at the phosphorus-31 (31P) frequency of a 3T MRI scanner (51.7 MHz) to acquire a phosphorus-31 spectrum of a selected brain region. Must be capable of transmitting and receiving at the proton frequency of a 3T MRI scanner (127.7 MHz) to generate proton images for phosphorus voxel placement and registration. Must fit within the body coil of a Philips 3T Elition X / MR7700 MRI scanner and fasten securely to the scanner bed to avoid image artifacts. Must have an inner diameter of at least 26 cm to comfortably fit subject�s head. Must have an active coil length of at least 24 cm to scan the entire brain in the superior-inferior direction. Must have a radio-frequency and DC electrical interface compatible with a Philips 3T Elition X / MR7700 MRI scanner (via Philips-supplied adapter box if needed). Must include probe description files and any other code needed to interface the coil to the scanner�s acquisition software (Gyroscan R5.9 / R11.1 or above). Must incorporate quadrature polarization on proton channel to maximize efficiency for 1H spin excitation and signal detection. Must be capable of exciting and receiving a proton NMR spectrum of a standard 85% phosphoric acid phantom with a minimum signal-to-noise ratio of 20:1 in one scan and a maximum line width (full width at half maximum) of 10 Hz in order to produce proton images of sufficient quality to allow reliable phosphorus voxel placement. Must incorporate quadrature polarization and active decoupling on phosphorus-31 transmit channel to maximize efficiency for 31P spin excitation. Must demonstrate ability to excite phosphorus-31 (31P) nuclei in a standard 85% phosphoric acid phantom with flip angles from 10 degrees to 270 degrees with an error of no more than 5% from the theoretical sinusoidal dependence of integrated signal on flip angle. This is needed to prevent artifacts in spin-echo and stimulated-echo experiments in which 31P must be excited with precise flip angles. Must incorporate eight phosphorus-31 receive channels and active decoupling to maximize sensitivity for 31P signal reception. Must receive a phosphorus-31 signal from a standard 85% phosphoric acid phantom with a minimum signal-to-noise ratio of 20:1 in one scan and a maximum line width (full width at half maximum) of 10 Hz in order to achieve adequate sensitivity in human brain spectroscopy experiments. Quantity: 1 Delivery Date: 8 months ARO Place of Performance: 251 Bayview Blvd Baltimore, MD 21224 Capability statement /information sought. Contractors that believe they possess the ability to provide the requirement should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. The response should directly and specifically state in the, capabilities statement, which project requirements you can supply. Contractors must also provide their Company Name, DUNS Number, Physical Address, Point of Contact, and Size and Type of Business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit.� The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses (capability statements) sent in response to this Small Business Sources Sought Notice must be submitted electronically (via e-mail) to the Contract Specialist. Facsimile responses are NOT accepted. The response must be submitted to Andrea Clay, Contract Specialist at e-mail address amcgee@mail.nih.gov The response must be received on or before July 21, 2023 at 12:00PM, eastern time. ��Disclaimer and Important Notes:� This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).�
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/85a91d3416e543a9945220bdeaf05dbb/view)
- Place of Performance
- Address: Baltimore, MD 21224, USA
- Zip Code: 21224
- Country: USA
- Zip Code: 21224
- Record
- SN06742820-F 20230712/230710230052 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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