Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF JULY 21, 2023 SAM #7906
SOURCES SOUGHT

66 -- Fluorescence Lifetime Imaging Confocal Microscopy System, STELLARIS 8 FALCON or Equal

Notice Date

7/19/2023 3:55:58 PM
 

Notice Type

Sources Sought
 

NAICS

334516 — Analytical Laboratory Instrument Manufacturing
 

Contracting Office

NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
 

ZIP Code

20892
 

Solicitation Number

75N95023Q00489
 

Response Due

7/26/2023 1:00:00 PM
 

Archive Date

08/10/2023
 

Point of Contact

Marlene Milgram, Phone: 3015940864
 

E-Mail Address

marlene.milgram@nih.gov
(marlene.milgram@nih.gov)
 

Description

The research programs at the Synaptic Functions Section (SFS) of the National Institute of Neurological Disorders and Stroke (NINDS) focus on mechanisms regulating axonal transport, which are essential to the maintenance of synaptic function and axonal homeostasis. The long-term goal of the STS Lab is to decipher mechanisms for (1) boosting axonal and synaptic energy metabolism and (2) enhancing autophagy-lysosomal function for efficient clearance of dysfunctional organelles and aggregated proteins that are associated with major neurodegenerative diseases. Research programs at the SFS aim to investigate axonal mitochondrial energy metabolism and lysosomal degradation capacity in neurons in health and neurodegenerative diseases. These programs and supporting research studies heavily rely on live neuron time-lapse imaging. �Recent technological advancements in confocal microscope systems enable super-resolution imaging of subcellular and molecular structures (<100nm) and real-time quantitative measurements of dynamic cellular metabolism and function. In addition, these systems enable high-sensitivity and high-speed scanning capacity with reduced phototoxicity to specimens, thus enhancing spatial and temporal resolution. Pursuing these studies will advance the knowledge of fundamental processes that may affect human neurological disorders, and thus directly align with the mission and strategic plan of NINDS. Therefore, the SFS requires a Fluorescence Lifetime Imaging Microscopy (FLIM) System: Leica STELLARIS 8 FALCON or equal. Please see the attached Sources Sought Notice for more details.�
 

Web Link

SAM.gov Permalink
(https://sam.gov/opp/704c386e140f42b1996ae509249403ee/view)
 

Place of Performance

Address: Bethesda, MD 20892, USA

Zip Code: 20892

Country: USA
 

Record

SN06756135-F 20230721/230719230052 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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