Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF JULY 22, 2023 SAM #7907
SOLICITATION NOTICE

A -- Comprehensive toxicity analysis of individual ENDS

Notice Date

7/20/2023 10:24:44 AM
 

Notice Type

Combined Synopsis/Solicitation
 

NAICS

541690 — Other Scientific and Technical Consulting Services
 

Contracting Office

FDA OFFICE OF ACQ GRANT SVCS Beltsville MD 20705 USA
 

ZIP Code

20705
 

Solicitation Number

FDA-RFP-75F40123R00115
 

Response Due

8/4/2023 10:00:00 AM
 

Archive Date

08/19/2023
 

Point of Contact

Lisa Jackson, Phone: 2404020093, Erika Eam
 

E-Mail Address

lisa.jackson@fda.hhs.gov, Erika.Eam@fda.hhs.gov
(lisa.jackson@fda.hhs.gov, Erika.Eam@fda.hhs.gov)
 

Description

The Contractor shall investigate the toxicity of 125 flavor ingredient chemicals alone and combined with metal using high throughput assays. The FDA will produce a final library of 125 flavor ingredient chemicals based on the predicted propensity of flavor ingredient chemicals to interact with metals. The Contractor shall perform cytotoxicity assays and measurements of cytokine levels in the supernatant to determine appropriate sublethal concentrations of flavor ingredient chemicals and metals to use in subsequent mutagenic and genotoxic assays, which consist of assays in cells lines and in bacteria. The Contractor shall determine based on measurables of the mutagenic and genotoxic experiments a list of 20 flavor ingredient chemicals and 20 flavor-metal combinations and their concentrations to be tested in the reconstructed human lung tissue model to measure the effects on metabolism, membrane integrity, cell viability, inflammation, and DNA damage. The Contractor shall perform all data analyses, provide FDA all of the raw data, and write study reports.
 

Web Link

SAM.gov Permalink
(https://sam.gov/opp/ed4e371c3a404033a12546712755c887/view)
 

Place of Performance

Address: USA

Country: USA
 

Record

SN06756724-F 20230722/230720230048 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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