SOURCES SOUGHT
66 -- High-Throughput Long-Read Sequencing System
- Notice Date
- 8/3/2023 1:05:46 PM
- Notice Type
- Sources Sought
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIAID BETHESDA MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- SS-NIAID-23-2175774
- Response Due
- 8/15/2023 9:00:00 AM
- Archive Date
- 08/30/2023
- Point of Contact
- Kathy Song, Phone: 301-761-7648
- E-Mail Address
-
kathy.song@nih.gov
(kathy.song@nih.gov)
- Description
- Introduction This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. Project Summary The National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC) is seeking to acquire one (1) high-throughput native long-read sequencing system to be used for studies of immune adaptive receptor use; host genomic associations with vaccine responses and disease progression; the microbiome; pathogen sequence diversity within and among infected people; and host cellular reservoirs of pathogens. To achieve these goals, the VRC utilizes next-generation sequencing methodologies that include bulk and single cell TCR, Ig and whole transcriptome sequencing, targeted genomic sequencing of specific loci, whole genome sequencing, shotgun microbiome metagenomics, and long-read/consensus pathogen sequencing. With these sequencing methodologies, the VRC is in need of a high-throughput native long-read sequencing system to help its sequencing core run more efficiently and effectively. Specifically, NIAID, VRC is seeking one (1) high-throughput native long-read sequencing system that includes the sequencing instrument, sequencing chips, sequencing reagents, and primary analysis compute along with instrument training and a one-year warranty. The sequencing system must meet all the required minimum technical requirements listed below: Shall be capable of holding and running/processing up to 4 Single Molecule, Real-Time (SMRT) Cell Trays simultaneously. SMRT cell trays are a consumable part which are nanofabricated with 25 million Zero-Mode Waveguides (ZMW) wells where prepared samples are loaded. Shall be capable of SMRT sequencing methodology. Run time shall be no more than 24 hours. Capable of running 1300 genomes a year. Able to load reagents while the machine is running. Shall be capable of independently and repeatedly analyze both strands from circular DNA molecules. Shall be a stand-a-lone, HiFi, high throughput native long-read sequencing system. Shall be capable of producing data demonstrating small variants, structural variants, repeat expansions, methylation, and haplotype phasing from a single library and sequencing run. Shall be capable of on instrument base calling. Shall be capable of on instrument Binary Alignment Map (BAM) file generation. Shall be capable of on instrument methylation calling. Shall include one-year warranty to meet the following: The Contractor shall provide updates and upgrades for 12 months from date of installation. Updates and upgrades will be for parts, software, and any reagents/kits. The Contractor shall provide access to technical support for this upgrade via email or telephone for 12 months from date of installation. Contractor shall provide the installation of the unit and ensure they meet or exceed original equipment manufacturer (OEM) operating standards. Contractor shall provide onsite training to approximately 2-4 people. Installation, Training, and Warranty: Upon delivery and installation, the Contractor shall coordinate with the Contracting Officer Representative (COR) to demonstrate functionality and schedule a training session with program office points of contact to conduct the training. The training shall be detailed and capture full functionality of the machine. At the end of the training, the vendor shall transition over training aids, materials, and technical guides to support utilization/maintenance of the machine. Offered systems shall be a turn-key solution i.e., the contractor shall be responsible for providing all hardware, components, instruments, computers, software, and that otherwise required to meet these specifications and the NIAID�s stated need. The systems shall be delivered with all necessary supplies and accessories required for installation and start-up. Systems shall be warranted for not less than one (1) year from NIAID acceptance of the system(s). Post-Warranty Service Minimum Performance Requirements: The Contractor shall provide one (1) scheduled on-site planned preventive maintenance visits per year. The Contractor shall provide unlimited On-Site Corrective Maintenance/Repairs within 3 business days of call for service where problems cannot be resolved remotely after 2 business days. The maintenance and repair activities shall be performed by the service engineers who are trained and certified by the OEM. The service provider should follow the OEM specifications, manuals, and service bulletins, using OEM-certified replacement parts, components, subassemblies, etc. The Contractor shall include free software and firmware updates required during on-site instrument repair and instrument�s performance check during preventive maintenance during the coverage period(s). The Contractor shall provide factory-certified replacement parts. The Contractor shall include unlimited technical support (via phone and email) on software and hardware and troubleshooting with the equipment issues, Monday through Friday (excluding Federal Holidays) 8:00AM � 5:00PM Central Time. All maintenance/repair pricing shall be inclusive of labor, travel, replacement parts, components, subassemblies, etc. for the system. Service Records and Reports: The Contractor shall, commensurate with the completion of each service call (inclusive of warranty service), provide the end-user of the equipment with a copy of a field service report/ticket identifying the equipment name, manufacturer, model number, and serial number of the equipment being serviced/repaired and detailing the reason for the service call, a detailed description of the work performed, the test instruments or other equipment used to affect the repair or otherwise perform the service, the name(s) and contact information of the technician(s) who performed the repair/service, and for information purposes, the on-site hours expended, and parts/components replaced. In addition, the Contractor shall provide a written report to the NIAID COR and Contract Specialist, summarizing all maintenance and repair activities (including warranty work) each time service and/or repair is performed. Anticipated Period of Performance It is anticipated that an award will be made on or about September 25, 2023. Delivery of the sequencing system is preferred as soon as possible and required within 30 days. Capability Statement/Information Sought If your organization has the potential capacity to provide a high-throughput, long-read sequencing system which meets the minimum requirements and performance capabilities listed above, please provide the following information: Organization name, address, point of contact, email address, website address, telephone number, UEI number. Type of business (e.g., 8(a), HUBZone, Other than Small, etc.)� pursuant to the applicable NAICS code. Identification of any Best-In-Class contract vehicles including Government Wide Acquisition Contracts (GWAC) (e.g., GSA schedule) they may possess or are aware of that would support this possible requirement. If your organization does not provide the products/services under a GWAC, please identify availability as OPEN MARKET ONLY. Tailored capability statement addressing the capability of the sequencing system to meet NIAID�s minimum requirements. Capability document shall be no more than six pages. Place of manufacture for the sequencing system and components. Evidence that the organization is an authorized reseller or manufacturer of the high-throughput long-read sequencing system. Authorized resellers shall identify the OEM of the equipment proposed in their capability statement. Only OEM products are acceptable. Submission Instructions Interested businesses who consider themselves qualified to provide the above listed high-throughput long-read sequencing system are invited to submit a response to this Sources Sought Notice by August 15, 2023, at 12:00 PM EST. All responses under this Sources Sought Notice shall be emailed to Kathy Song at kathy.song@nih.gov. Disclaimer and Important Notes This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/dfaf69874df949849a93b6252ef6fce1/view)
- Place of Performance
- Address: Bethesda, MD 20892, USA
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN06776573-F 20230805/230803230059 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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