Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF AUGUST 11, 2023 SAM #7927
SOURCES SOUGHT

A -- EXTRACTION OF HIGH CONTENT TOXICITY BIOMARKER DATA FOR THE DIVISION OF TRANSLATIONAL TOXICOLOGY

Notice Date

8/9/2023 8:35:10 AM
 

Notice Type

Sources Sought
 

Contracting Office

NATIONAL INSTITUTE OF HEALTH NIEHS MORRISVILLE NC 27560 USA
 

ZIP Code

27560
 

Solicitation Number

75N96023Q00110A
 

Response Due

8/14/2023 11:00:00 AM
 

Archive Date

08/14/2023
 

Point of Contact

ODESSA MCGLOWN, Henry Daniels
 

E-Mail Address

ODESSA.MCGLOWN@NIH.GOV, henry.daniels@nih.gov
(ODESSA.MCGLOWN@NIH.GOV, henry.daniels@nih.gov)
 

Description

The NIEHS seeks information on contract support DTT requires support to generate robust summaries of transcriptional biomarkers of toxicity/disease in different tissues and organs. These summaries can then be used to characterize adversity in in vivo toxicity screens where gene expression is measured in a dose response format across multiple tissues. DTT is specifically interested in up/down-regulated organ/tissue transcriptional biomarkers of adversity (toxicity or disease) in mammalian models with an emphasis on rats. Specific tissues for which biomarkers shall be identified and curated may include liver, kidney, heart, lung, thyroid, spleen, skeletal muscle, gastrointestinal tract, testis, adrenal gland, ovaries, uterus, pancreas, bone marrow, and blood. Genes shall be identified with associated publications cited along with known eliciting agents (i.e., chemical treatments, dietary modifications, genetic models). Once a gene is identified, upstream mechanistic processes shall be curated to explain the response of each gene. The mechanistic curation shall ideally be organ/tissue specific but may also be more generalizable.�
 

Web Link

SAM.gov Permalink
(https://sam.gov/opp/ef24da2a85004b05a3a4dbd92e8c728b/view)
 

Place of Performance

Address: USA

Country: USA
 

Record

SN06784036-F 20230811/230809230056 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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