SPECIAL NOTICE
66 -- Opera Phenix� Plus with 2 Cameras and 4 High Power Lasers Microplate Confocal Imager for High Throughput Screening
- Notice Date
- 8/14/2023 9:05:43 AM
- Notice Type
- Special Notice
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- 75N95023Q00461
- Response Due
- 8/21/2023 9:00:00 AM
- Archive Date
- 09/05/2023
- Point of Contact
- Kaitlyn Landi, Phone: 3018271804
- E-Mail Address
-
kaitlyn.landi@nih.gov
(kaitlyn.landi@nih.gov)
- Description
- INTRODUCTION THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Office of Acquisition (OA) the National Center for Advancing Translational Sciences (NCATS), intends to negotiate and award a purchase order without providing for full and open competition (including brand-name) to PerkinElmer Health Sciences Inc 710 Bridgeport AVE Shelton CT 06484 for Opera Phenix� Plus with 2 Cameras and 4 High Power Lasers Microplate Confocal Imager for High Throughput Screening. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET ASIDE STATUS The intended procurement is classified under NAICS code 334516 Analytical Laboratory Instrument Manufacturing with a Size Standard of 1000. � REGULATORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13�Simplified Acquisition Procedures. Contracts awarded using FAR Part 13�Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6�Competition Requirements. FAR Subpart 13.106-1 (b) Soliciting from a single source provides that: For purchases not exceeding the simplified acquisition threshold, Contracting officers may solicit from one source IF the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, brand-name OR industrial mobilization). The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2022-08 dated October 22, 2022. DESCRIPTION OF REQUIREMENT PURPOSE AND OBJECTIVES: Acquisition of one (1) Opera Phenix� Plus with 2 Cameras and 4 High Power Lasers� Microplate Confocal Imager for High Throughput Screening Purchase Description and Salient characteristics: The Opera Phenix� high resolution scanning system is a commercially available item that is customized with options to fit the specific laboratory needs.� For reference, the PerkinElmer Opera Phenix� High Content Screening Systems that meets the needs of this requirement includes the following Perkin Elmer Part Numbers: HH14001000, HH14001001, HH14000121, Lasers: - 405 nm 200mW - 488 nm 150mW - 561 nm 100mW - 640 nm 140mW, HH14000302, Two sCMOS cameras: - 4.7 mega pixel (2160 x 2160) - 16-bit resolution - 6.5um pixel size - Simultaneous acquisition of two channels Includes filters for the following emission bands: - 435-550 nm - 435-480 nm - 500-550 nm - 570-630 nm - 650-760 nm, HH14000050, HH14000793, HH14001603, HH14000421 OperaPHX/OPRTCLS Water Objective 20x 20x Water Immersion Objective: NA 1.0, WD 1.7 mm (field of view: approx. 646 ?m x 646 ?m) Compatible with: Opera Phenix and Operetta CLS Installation: Required but not included, �HH14000403, OperaPHX/OPRTCLS Air Objective 10x 10x Air objective: NA 0.3, WD 5.2 mm (field of view: approx. 1292 ?m x 1292 ?m) Compatible with: Opera Phenix and Operetta CLS Installation: User exchangeable,� HH20110151, HH1410000, Installation of the Opera Phenix instrument by PerkinElmer service Engineers, HH14000888 Basic training Each High Content Scanning System (HCSS) must meet the following requirements: 1.The HCSS must be a complete self-contained high content screening system with internal imaging optics and plate scanning hardware and software designed to automatically image and analyze multi-well plates up to 1536 wells. 2.The HCSS must include a Micro Lens Enhanced Dual Spinning Disk Confocal Unit with fifty (50) micron (um) pinhole diameter and at least 550 um spacing between pinholes. 3.The HCSS must include two (2) Scientific Complementary Metal Oxide Semiconductor (sCMOS) Cameras as Detectors with at least 4.4 million pixels each for simultaneous two (2) channel capture. 4.The HCSS must provide a confocal optical system which separate excitation of adjacent fluorescence channels in time and space to reduce spectral crosstalk during simultaneous multicolor confocal imaging. 5.Fluorescence excitation must be provided by solid state lasers with the following characteristics: 405 nanometers (nm) with at least 200 milliWatts (mW) power; 488 nm with at least 150 mW power; 561 nm with at least 100 mW power; 640 nm with at least 140mW power. 6.The HCSS must be field upgradable to a total of four (4) sCMOS Camera Detectors for 4 channel simultaneous image capture. The field upgrade must be possible with no system downtime while the upgrade is performed. 7.The HCSS must include at least an eight (8) position emission filter wheel for each detector to provide flexibility for using multiple fluorescent dyes or proteins. 8.The HCSS must include a six (6) position objective turret. 9.All objectives must be barcoded for automatic recognition and configuration. 10.The HCSS must include at least three (3) simultaneously mounted water immersion objectives. 11.The HCSS must include an integrated Water Pump Kit to provide continuous water feed. This shall enable the use of the water immersion objectives for scanning an entire multi-well plate. 12.The HCSS must include Digital Phase Contrast to provide visualization and segmentation of unstained cells. The HCSS must keep live cells functioning normally and eliminate the need for nuclear dyes which destroy cellular function. 13.The HCSS must allow simultaneous on-line acquisition, analysis and evaluation of images and data. 14.Data analysis must be possible at both the single cell and plate level to provide results from assays in the selected format. 15.The HCSS must include single cell tracking software. This is needed for cell lineage experiments. 16.The HCSS must provide advanced morphology features (�STAR method�) that allow quantification of various aspects of the form and structure of objects e.g. elongation, symmetry, and smoothness of the border and spatial distribution of intensity of texture features. 17.The HCSS must include texture analysis which uses pixel distribution to select objects for quantitation when neither simple intensity Thresholding nor STAR morphology will work. 18.The HCSS must include Machine Learning software for pattern recognition selection for analysis. The software must allow users to train the system to select and quantitate specific types of cells, etc. by simply drawing on the objects of interest. 19.The HCSS must include an environmental chamber to control temperature and carbon dioxide concentration. The environmental chamber must permit use of all optical techniques including transmitted light brightfield and Digital Phase Contrast. 20.The HCSS must come with basic user training for at least 5 different users and 16 total hours.� The training can be provided for the users at the same time in a group setting. Installation and delivery shall be performed by the contractor. ESTIMATED DELIVERY or PERIOD OF PERFORMANCE: 4-6 weeks ARO CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, PerkinElmer Health Sciences Inc 710 Bridgeport AVE Shelton CT 06484 is the only vendor in the marketplace that can provide the services required by NIDA . The intended source is: PerkinElmer Health Sciences Inc 710 Bridgeport AVE Shelton CT 06484 CLOSING STATEMENT THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must be received by the closing date and time of this announcement and must reference the solicitation number, 75N95023Q00461. Responses must be submitted electronically to Kaitlyn Landi, Contract Specialist, at kaitlyn.landi@nih.gov and KJ Shaikh, Contracting Officer, at kj.shaikh@nih.gov.� U.S. Mail and fax responses will not be accepted.
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