SPECIAL NOTICE
70 -- PONEMAH OPERATING ROOM SYSTEM
- Notice Date
- 5/23/2024 1:01:52 PM
- Notice Type
- Special Notice
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH Bethesda MD 20892 US
- ZIP Code
- 20892
- Solicitation Number
- NOI-NIAID-24-2216214
- Response Due
- 6/3/2024 9:00:00 AM
- Archive Date
- 06/18/2024
- Point of Contact
- Maliaka Pinkney, Phone: 2406695308, Jesse D Weidow, Phone: 4063759783
- E-Mail Address
-
maliaka.pinkney@nih.gov, weidowjd@niaid.nih.gov
(maliaka.pinkney@nih.gov, weidowjd@niaid.nih.gov)
- Description
- This is a Notice of Intent, not a request for proposal. The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) intends to negotiate an other than full and open competition basis with the Data Science International, Inc. for the�Ponemah Operating System. The VRC, Virology Laboratory (VL) within the National Institute of Allergy and Infectious Diseases (NIAID) comprises the Virology, Humoral Immunology, and Structural Biology Sections and related Cores. The goal of the Virology Laboratory is to conduct research to better understand the cellular and molecular regulation of viral gene expression, viral entry into the host cell, optimization of immune responses to gene-based vaccination and correlates of immune protection, assessment of active and passive approaches for HIV-1 vaccine development, and to apply structural biology techniques toward rational vaccine design for emerging and re-emerging infectious diseases. The work of the Virology Laboratory is closely integrated with other VRC basic and translational research Laboratories and Cores to facilitate research and development of novel vaccine candidates against pathogens threatening public health.??? The VL has developed a nonhuman primate model that allows for continuous physiological monitoring and frequent blood sampling to characterize pathophysiology and cellular and molecular pathogenesis of critical illness due to severe infection. These studies require monitoring from the time of infection to the study endpoint. During this period, the study animals will be awake in their cage or sedated inside a critical care setting receiving supportive care. The conditions in the critical care setting replicate the treatment humans receive in modern ICUs including sedation, analgesia, and invasive mechanical ventilation; fluid, electrolyte, and acid-base management; and intravenous administration of vasopressors, antibiotics, steroids, and other medicines.� The implantable telemetry platform will provide continuous physiological monitoring at different stages of disease whether the animals are sedated or awake. Awake animals can be monitored in their cage outside of the ICU. The monitoring of awake animals avoids the need for extended periods in the ICU where animals are sedated. Such extended ICU periods would not mimic the experience of humans in the early stages of illness and would also make the models untenable by requiring additional staffing and financial cost. From a research standpoint, the telemetry platform will be used to determine the progression of disease in multiple animals at the same time after they are infected but prior to the animals being sedated in the ICU. Continuous physiologic data gathered during this period will add to our understanding of pathogenesis early after infection and inform decisions about an optimal time interval to administer therapeutics. Ultimately, telemetry will be used to evaluate effectiveness of therapies in this model. The statutory authority for this sole source requirement is 41 U.S.C. 253 (c) (1) as implemented by FAR 13.106-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A REQUEST FOR PROPOSAL. All responsible sources that could provide comparable services may submit a capability statement that will be considered by email (subject line to reference NOI-NIAID-24-2216214 in the eSASS system, by 12:00 pm eastern standard time June 3, 2024. All quotations and required documents must be submitted via the NIAID electronic Simplified Acquisition Submission System (eSASS) website at https://esass.nih.gov. All vendors must register in the eSASS system to submit a quotation. Instructions on how to register / submit quotes are included on the website. Late submissions shall be treated in accordance with the solicitation provision at FAR 52.212-1(f). All responsible sources may submit an offer that will be considered by this Agency.�
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/4f601fcfc1a7452c8040956e9dbaed5b/view)
- Place of Performance
- Address: Dickerson, MD 20842, USA
- Zip Code: 20842
- Country: USA
- Zip Code: 20842
- Record
- SN07074748-F 20240525/240523230055 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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