SPECIAL NOTICE
Q -- SomaScan 7K Assay Proteomic Analysis Services For Radiation Induced Changes in the Geriatric Murine Blood Proteome
- Notice Date
- 7/9/2024 3:17:17 PM
- Notice Type
- Special Notice
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- NIH NCI Bethesda MD 20892 USA
- ZIP Code
- 20892
- Response Due
- 7/12/2024 9:00:00 AM
- Archive Date
- 07/27/2024
- Point of Contact
- Miguel Diaz
- E-Mail Address
-
miguel.diaz@nih.gov
(miguel.diaz@nih.gov)
- Description
- ISSUED BY:� National Institutes of Health (NIH), National Cancer Institute (NCI), Office of Acquisitions (OA)� DESCRIPTION:� The Department of Health and Human Services (DHHS), National Institutes of Health (NIH), National Cancer Institute (NCI), Center for Cancer Research (CCR) intends to procure analysis services, on a sole source basis, from SomaLogic Operating Co., Inc. of 2945 Wilderness Place, Boulder, CO 80301. This acquisition will be processed under FAR Part 12 � Acquisition for Commercial Items and will be made pursuant to the authority in FAR Part 13.106-1(b)(1); and is exempt from the requirements of FAR Part 6. The response close date of this notice for this requirement is in accordance with FAR 5.203(a)(1). The North American Industry Classification System (NAICS) code is 541380 and the business size standard is $19 million. This notice is not a request for competitive quotations. However, if any interested party, especially a small business, believes it can meet the Government�s needs, it may submit a capability statement, proposal, or quote for the Government to consider. The response and any other information furnished must be in writing and must contain sufficient details to allow NCI to determine if the party can perform the requirement. Responses to this notice shall be submitted via email to the Contracting Officer, Miguel Diaz, no later than the date specified in this notice. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered for the purpose of determining whether to conduct a competitive procurement. The Government reserves the right to use the information provided by respondents for any purpose deemed necessary and legally appropriate. To receive an award, Contractors must be registered and have valid certification through SAM.GOV. Please reference the notice number on all correspondence. 1.0�� �TITLE SomaScan 7K Assay Proteomic Analysis Services for Radiation Induced Changes in the Geriatric Murine Blood Proteome 2.0�� �BACKGROUND The Radiation Oncology Branch (ROB) at the National Cancer Institute�s (NCI�s) Center for Cancer Research (CCR) designs and conducts pre-clinical and clinical research on the biologic and therapeutic effect of radiation therapy. The laboratory has characterized novel radiation responsive proteins and correlated their patterns of expression with absorbed dose in models of both total body and partial body exposure. Since 2020, the laboratory utilizes SomaScan (SomaLogic, Inc.) assays which allow the simultaneous analysis of a high number of protein analytes from a single small volume (130 ul) sample. The NCI�s most recent work using the SomaScan 1.3K Analyte assay, which uses a proprietary aptamer-based approach to simultaneously screen 1,310 analytes, yielded novel panels of significantly altered proteomic biomarkers of radiation exposure. The collective studies have consistently shown that higher predictive accuracies for radiation exposure and level of dose prediction are achieved when multiple biomarkers are used, and the benefit of taking advantage of highly multiplexed proteomic expression analysis technologies. 3.0�� �OBJECTIVE The primary objective of this project is to expand on previous studies by using the latest SomaScan Discovery 7K Analyte assay (version v4.1), delivering 7,000 protein measurements from plasma with total body and partial body radiation exposures. The NCI will characterize proteomic signatures specific to total body radiation exposures in male and female animals aged 24 and 50 weeks. 4.0�� �SCOPE The scope of the work to be performed is limited to a single screening of proteomic biomarkers in 132 murine plasma samples submitted to SomaLogic, Inc. for application on their SomaScan assay platform. The work shall include sample processing, running of the assay which analyzes over 7,000 proteins, and final data analysis. Data analysis shall include internal standardization and normalization, and preparation of a final report. 5.0�� �CONTRACT REQUIREMENTS 5.1�� �TASK 1: PROCESS EACH SAMPLE RECEIVED Upon receipt of all 132 samples from the Government, the Contractor shall verify each sample label and the overall inventory of samples. The Contractor shall also aliquot from primary samples and any necessary dilutions for application on the assay platform. 5.2�� �TASK 2: RUN ASSAY ANALYSIS The Contractor�s assay analysis shall include a single analysis per sample of 7,000 protein analytes conducted on samples of at least 130 �L using their proprietary Somascan 7K Assay. The analysis shall quantify proteins that span no less than 8 logs in abundance (from femtomolar to micromolar), with reproducibility of 4.6 median % CV (co-efficient of variation). Measurements shall be taken in three dislutions, with plasma diluent. The Contractor shall measure native proteins in complex matrices by transforming each individual protein concentration into a corresponding reagent concentration, which shall then be quantified by standard DNA techniques (microarrays or qPCR). 5.3�� �TASK 3: DELIVER FINAL DATA AND ANALYSIS REPORT The Contractor shall deliver a final report inclusive of all data points which includes analysis data normalized against intra-assay controls, and secondary normalization to interpolate control standards. Data shall be supplied for all submitted samples in the form of Relative Fluorescent Units (RFU) for all aptamers present in the assay. The report shall be provided in .adat file format. NOTE: All data generated shall be the sole property of the U.S. Government. 6.0�� �GOVERNMENT RESPONSIBILITIES The Government Technical Point of Contact (TPOC) will coordinate with the Contractor to deliver samples to the Contractor�s facilities. Samples will be shipped no later than 45 calendar days after award. The Government will be responsible for arranging shipment of samples to and from the Contractor. Samples are ready for shipment. Residual samples shall be returned within 6 months following the completion of analysis on dry ice. 7.0�� �TYPE OF ORDER This is a firm fixed price purchase order for non-severable services. 8.0�� �PERIOD OF PERFORMANCE The period of performance shall be twelve months from 09/01/2024 to 08/31/2025. 9.0�� �PLACE OF PERFORMANCE All work shall be performed at the Contractor�s facilities. 10.0�� �TECHNICAL POINT OF CONTACT The Technical Point of Contact (TPOC) is responsible for inspection and acceptance of all work in relation to this requirement and will serve as the Governments primary point of contact throughout the duration of the requirement. All efforts must be coordinated with this individual. The TPOC has limited authority as defined within this Statement of Work. They do not have the authority to commit or obligate Government funds or make changes to the terms and conditions of the purchase order. As such, any changes to the purchase order must be performed by a warranted Government Contracting Officer with appropriate delegated authority to do so. 11.0�� �INSPECTION AND ACCEPTANCE Pursuant to FAR clause 52.212-4, all work described in the SOW is to be delivered under this purchase order is subject to final inspection and acceptance by an authorized representative of the Government. The authorized representative of the Government is the TPOC who is responsible for the inspection and acceptance of all services, materials, or supplies to be provided by the Contractor. Regardless of format, all digital content or communications materials produced as a deliverable under this purchase order, shall conform to applicable Section 508 Standards to allow Federal employees and members of the public with disabilities to have access to and use of information and data that is comparable to the access to and use of information and data by Federal employees or by members of the public who are not individuals with disabilities. Remediation of any materials that do not comply with the applicable Section 508 requirements as set forth below, shall be the responsibility of the Contractor. HHS guidance regarding accessibility of documents can be found at: https://www.hhs.gov/web/section-508/making-files-accessible/create-accessiblepdfs/index.html. Federal Government-wide guidance regarding accessibility of documents can be found at https://www.section508.gov/, including the documents describing the preferred method of authoring and testing documents produced in Microsoft Word 2013 or later, Microsoft Excel, and files formatted as PDF. 12.0�� �REPORT(S)/DELIVERABLES AND DELIVERY SCHEDULE The below table outlines the deliverables which the Contractor is responsible for fulfilling throughout the requirement. All deliverables shall be submitted electronically to the TPOC for inspection and acceptance. DELIVERABLE�� �DESCRIPTION�� �DUE DATE Task #1 (see Section 4.1)�� �Email confirmation of receipt of samples�� �Immediately upon receipt of delivery. Task #2 (see Section 4.2)�� �Performance of 132 SomaScan Discovery 7K Analyte assays�� �Within 8 weeks of receipt of samples Task #3 (see Section 4.3)�� �Delivery of final data analysis report�� �Within 8 weeks of receipt of samples Electronic copies of the final report shall be provided in .adat file format within 30 days following submission of biological samples. The report shall be sent electronically to the TPOC. Nature of the acquisition and proposed unique qualifications of the contractor(s). � NCI�s ROB has previously utilized SomaLogic Inc�s 7K SomaScan V4.1 in support of ongoing research involving proteomic analyses for the identification of radiation biomarkers in small-volume samples from murine and human plasma. The current study is a continuation of previous efforts performed by SomaLogic Inc in their lab, utilizing their SomaScan V.4.1 platform and experimental protocols and data normalization processes. As such SomaLogic is the only vendor able to maintain scientific comparability of the previously generated data related to ROB�s ongoing research. Therefore, SomaLogic is the only vendor with the required technical capabilities needed to maintain scientifically comparable results with related past efforts and studies utilizing 7K SomaScan V4.1. Inconsistency in resulting data would lead to unacceptable delays and substantial duplication of cost to the NCI, not expected to be recovered through competition.
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/5ed9b0f62a184bbdac71434e77dfcccf/view)
- Place of Performance
- Address: Boulder, CO, USA
- Country: USA
- Country: USA
- Record
- SN07120846-F 20240711/240709230106 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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